The association between obesity and self‐reported sinus infection in non‐smoking adults: a cross‐sectional study

Christensen, Rebecca; Raiber, Lilian; Macpherson, Alison; Kuk, Jennifer L.

doi:10.1111/cob.12164

Cited by 9 publications

(9 citation statements)

References 39 publications

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“… 6 Other studies have shown that a high BMI was associated with the prevalence of CRS. 25 26 However, these studies did not classify the prevalence of CRS based on the presence of nasal polyps; therefore, the effect of adiposity on CRSwNP has not been determined.…”

Section: Discussionmentioning

confidence: 99%

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

et al. 2021

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ObjectivesWe performed a cross-sectional analysis of data from the nationwide Korea National Health and Nutrition Examination Survey to evaluate the association between obesity and chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyp (CRSsNP).DesignRetrospective cross-sectional analysis of health survey data.SettingVoluntary survey of representative South Korean populations.ParticipantsIn total, 32 384 individuals aged 19 years or older with available data on CRS and obesity were included.Primary and secondary outcome measuresDiagnosis of CRSwNP or CRSsNP was performed by trained otolaryngologists through sinus endoscopy and surveys of medical history. General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.MethodsA multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.ResultsThe prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p<0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p<0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p<0.001) showed a higher incidence in the central obesity group than in the control group.ConclusionsWe demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.

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Section: Discussionmentioning

confidence: 99%

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

et al. 2021

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“…Second, as diagnoses of AR and RS were self-reported, some recall bias may have been in play. However, other large population-based surveys used similar questionnaires to diagnose AR and sinus infections [ 57 – 59 ]. Third, the severity of both AR and RS may influence mental health and HRQoL, but we did not consider this possibility.…”

Section: Discussionmentioning

confidence: 99%

Allergic rhinitis and rhinosinusitis synergistically compromise the mental health and health-related quality of life of Korean adults: A nationwide population-based survey

et al. 2018

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BackgroundAllergic rhinitis (AR) and rhinosinusitis (RS) negatively impact psychological well-being and health-related quality of life (HRQoL). However, few population-based studies have investigated the effects of these conditions on mental health and HRQoL.PurposeTo explore independent associations of AR and/or RS with mental health and HRQoL using data from the 2013–2015 Korea National Health and Nutrition Examination Survey (KNHANES).MethodsThe KNHANES is a nationwide cross-sectional survey of the non-institutionalized population of Korea. A total of 15,441 adults completed the clinical examination and the health questionnaire. We divided all participants into four groups: AR-/RS-, AR-/RS+, AR+/RS-, and AR+/RS+. Logistic regression analyses were performed after adjustment for sociodemographic characteristics, general health behaviors, and other comorbidities.ResultsThe AR+/RS+ group contained the highest proportion of subjects with perceived stress and depressed mood. Subjects with AR+/RS+ also had more frequent problems in terms of pain/discomfort and anxiety/depression. After adjusting for all confounders, the odds ratios (ORs) were 2.96 (p = 0.009) for depressed mood and 3.17 (p = 0.013) for suicidal ideation in the AR+/RS+ group compared with in the AR-/RS- group. The AR+/RS- group reported more perceived stress (OR, 1.56, p = 0.003) and depression (OR, 1.72, p = 0.024) compared with the AR-/RS- group. In terms of the ORs for HRQoL, the AR+/RS+ group reported more problems in terms of self-care (OR, 3.73, p = 0.038) and more pain/discomfort (OR 2.19, p = 0.006) compared with the AR-/RS- group.ConclusionsIn the Korean population, AR and RS exerted a synergistic negative impact on mental health and HRQoL, especially suicidal ideation. Most patients seek help from clinicians for impaired HRQoL. Therefore, clinicians should consider the underlying mental health and HRQoL of patients with AR and/or RS, as these may be impaired by their conditions.

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“…Although a causal relationship has not been determined, both obesity and chronic rhinosinusitis are characterized by chronic inflammation. 16,17 In our series, it is difficult to assign specific meaning to a 4-point elevation in average BMI. However, both rhinosinusitis groups had average BMIs that were higher than the group without rhinosinusitis, which may point to the association between obesity, inflammation, and a predilection for sinusitis.…”

Section: Discussionmentioning

confidence: 78%

“…Both average BMIs are considered “obese” and multiple studies have demonstrated obesity to be a common comorbidity in patients with chronic rhinosinusitis. Although a causal relationship has not been determined, both obesity and chronic rhinosinusitis are characterized by chronic inflammation . In our series, it is difficult to assign specific meaning to a 4‐point elevation in average BMI.…”

Section: Discussionmentioning

confidence: 79%

Rate of rhinosinusitis and sinus surgery following a minimally destructive approach to endoscopic transsphenoidal hypophysectomy

Rimmer

Vimawala

Chitguppi

et al. 2019

Int Forum Allergy Rhinol

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Background There remains considerable variation in the extent of sinonasal preservation during the approach for endoscopic transsphenoidal hypophysectomy (TSH). We advocate for a minimally destructive approach utilizing turbinate lateralization, small posterior septectomy, no ethmoidectomy, and preservation of nasoseptal flap (NSF) pedicles bilaterally. Due to these factors, this approach may affect the rates of postoperative rhinosinusitis. The objective of this study is to define the rates of postoperative rhinosinusitis in patients undergoing this approach. Methods Single institution, retrospective chart review of patients undergoing TSH from 2005 to 2018. Results A total of 415 patients were identified and 14% developed an episode of postoperative rhinosinusitis within 3 months. These patients were significantly more likely to have had a history of recurrent acute or chronic rhinosinusitis. Most cases were sphenoethmoidal sinusitis managed with 1 to 2 courses of antibiotics. Of patients with postoperative rhinosinusitis, most did not undergo NSF. Average follow‐up was 38 months. Six patients (1.4%) underwent post‐TSH functional endoscopic sinus surgery (FESS). Average time from TSH to FESS was 26.3 months. Two of these patients had a history of prior chronic rhinosinusitis without polyposis. Two patients underwent revision TSH for recurrent tumor as the primary indication for surgery at time of FESS. Twenty‐two–item Sino‐Nasal Outcome Test (SNOT‐22) scores generally increased immediately postoperatively, but frequently decreased below preoperative level by the time of last follow‐up, regardless of whether patients developed rhinosinusitis. Conclusion Sinonasal preservation during TSH is associated with a low rate of postoperative rhinosinusitis requiring FESS and excellent long‐term patient reported outcomes. We continue to advocate for sinonasal preservation during pituitary surgery.

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The association between obesity and self‐reported sinus infection in non‐smoking adults: a cross‐sectional study

Cited by 9 publications

References 39 publications

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

Allergic rhinitis and rhinosinusitis synergistically compromise the mental health and health-related quality of life of Korean adults: A nationwide population-based survey

Rate of rhinosinusitis and sinus surgery following a minimally destructive approach to endoscopic transsphenoidal hypophysectomy

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