Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

Nam, Jae Sung; Roh, Yun Ho; Fahad, Wasan Almazouq; Ha, Jong Gyun; Yoon, Joo Heon; Kim, Chang Hoon; Cho, Hyung‐Ju

doi:10.1136/bmjopen-2020-047230

Cited by 19 publications

(26 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In greater depth, CRSwNP is reported in 40% of patients with severe asthma ( 4 , 5 ) and seems to be more prevalent in men ( 16 ) with no clear association with the presence of atopy ( 17 ). A recently published paper demonstrated the link between CRSwNP, asthma, and obesity ( 18 ), but we were not able to confirm these results. However, the retrospective nature of our study may have affected this outcome.…”

Section: Discussioncontrasting

confidence: 94%

Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis

D’Amato

Menzella²,

Altieri³

et al. 2022

Front. Allergy

View full text Add to dashboard Cite

BackgroundSevere eosinophilic asthma (SEA) in the presence of chronic rhinosinusitis with nasal polyps (CRSwNP) indicates the presence of a more extensive eosinophilic inflammation. Post-hoc analyses from a pivotal clinical trial have demonstrated the enhanced efficacy of benralizumab on asthma outcomes in patients with CRSwNP as a comorbidity.MethodsThis is a post-hoc analysis from the Italian multi-center observational retrospective ANANKE study. Patients were divided into two groups based on self-reported CRSwNP. Baseline clinical and laboratory features in the 12 months prior to benralizumab prescription were collected. Data of change over time of blood eosinophils, annualized exacerbations rates (AER), asthma control, lung function, oral corticosteroids (OCS) use, and benralizumab discontinuation were collected during the observation period.ResultsAt baseline, the 110 patients with CRSwNP were less frequently female (50.9% vs 74.2%) and obese (9.1% vs. 22.6%) with higher eosinophils (605 vs. 500 cells/mm3) and OCS use when compared to patients without CRSwNP. Similar reductions of AER were seen (-95.8% vs. −91.5% for any exacerbation and −99.1% vs. −92.2% for severe exacerbations in patients with and without CRSwNP, respectively). During benralizumab treatment, comorbid SEA+CRSwNP was associated with a lower risk of any exacerbation (p = 0.0017) and severe exacerbations (p = 0.025). After a mean ± SD exposure of 10.3 ± 5.0 months, half of the SEA+CRSwNP patients eliminated OCS use. No discontinuation for safety reasons was recorded.ConclusionsThis study helped to confirm the baseline clinical features that distinguish patients with and without CRSwNP being prescribed benralizumab. Numerically enhanced OCS reduction and lower exacerbation risk were observed in patients with SEA and comorbid CRSwNP treated with benralizumab.

show abstract

Section: Discussioncontrasting

confidence: 94%

Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis

D’Amato

Menzella²,

Altieri³

et al. 2022

Front. Allergy

View full text Add to dashboard Cite

show abstract

“…Male to female ratio was 1:1.6 in our study; there was female preponderance in all groups, with the difference between each of the experimental group (groups A, B, C, D, E) and control group (group F) being statistically insignificant (p-value = 0.34). This observation was consistent with study conducted by Nam J. S. et al (2021) [15]; however, Ahmed S. et al ( 2014) [16] showed male preponderance in their study. The difference in gender distribution from previous studies could be due to variation in demographic distribution from one population to other.…”

Section: Discussionsupporting

confidence: 92%

Obesity and ENT manifestations — a tertiary care centre study

Saraf

Manhas

et al. 2023

Egypt J Otolaryngol

View full text Add to dashboard Cite

Background The aim of our study was to assess whether there is role of obesity in ENT diseases like otitis media effusion, chronic otitis media, chronic rhinosinusitis, sudden sensorineural hearing loss and chronic tonsillitis, or not. Methods The present prospective study, after approval by institutional ethics committee, was conducted in the Department of ENT, SMGS Hospital, GMC Jammu from January 2021 to February 2022 on 590 patients, who were divided into 6 groups — group A — otitis media with effusion (n = 95 patients), group B — chronic otitis media (n = 171 patients), group C — sudden SNHL (n = 43 patients), group D — chronic rhinosinusitis (n = 102 patients), group E — chronic tonsillitis (n = 67 patients) and group F (control group) — patients (aged 11–50 years) coming to ENT OPD with other problems, except those problems mentioned in inclusion and exclusion criteria (n = 112 patients). Severity of disease was evaluated using Adelaide Disease Severity Score (CRS patients), otoscopy and pure tone audiometry (OME and COM), pure-tone audiometry (sudden SNHL) and Brodsky grading scale (chronic tonsillitis). Mean BMI and percentage of obese patients were calculated for each group. Results The mean age of presentation in our study was 40.66 ± 7.25 years. Male to female ratio was 1:1.6 in our study. The mean BMI in control group (group F) was 22.51 ± 3.01 kg/m2. The mean BMI was 25.41 ± 2.81 kg/m2 in group A, 25.33 ± 2.34 kg/m2 in group B, 25.12 ± 3.14 kg/m2 in group C, 25.78 ± 2.33 kg/m2 in group D and 25.03 ± 1.84 kg/m2 in group E, the difference between each of these groups and control group being statistically significant (p < 0.005). The percentage of obese patients in group F was 20.5% (23 patients). The percentage of obese patients was 53.6% (51 patients) in group A, 49.7% (85 patients) in group B, 39.5% (17 patients) in group C, 54.9% (56 patients) in group D and 31.3% (21 patients) in group E. Upon comparison with group F, the difference in percentage of obese patients was statistically significant in each group. Obese patients were more likely to have otitis media with effusion (OR 1.85, 95% CI 0.15 to 6.49), chronic otitis media (OR 1.80, 95% CI 0.15 to 6.33), sudden SNHL (OR 1.62, 95% CI 0.21 to 6.40), chronic rhinosinusitis (OR 2.05, 95% CI 0.15 to 6.55) and chronic tonsillitis (OR 1.60, 95% CI 0.16–6.13), than the control group. Conclusion Obesity leads to various ENT problems by altering the immune system. In our study, mean BMI was significantly higher in patients with otitis media effusion, chronic otitis media, chronic rhinosinusitis, sudden sensorineural hearing loss and chronic tonsillitis and also, as the severity of disease increased with increase in severity of BMI, showing positive correlation for all study groups, thus establishing association of obesity and these common otorhinolaryngological conditions.

show abstract

“…Factors linking the mucosal inflammation in CRS and asthma could be related to obesity and its potential to contribute to airway inflammation. Previous cross-sectional studies have demonstrated an association between obesity and CRS [ 14 – 16 ]. Nam et al investigated 32,384 individuals aged 19–86 years and, after performing a cross-sectional analysis, they found that the prevalence of CRS with nasal polyps was higher in subjects with obesity [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous cross-sectional studies have demonstrated an association between obesity and CRS [ 14 – 16 ]. Nam et al investigated 32,384 individuals aged 19–86 years and, after performing a cross-sectional analysis, they found that the prevalence of CRS with nasal polyps was higher in subjects with obesity [ 16 ]. Bhattacharyya conducted a cross-sectional analysis of a medical panel survey in the United States and found an adjusted odds ratio of 1.31 (1.18, 1.45) for CRS when obesity was present [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

Clarhed

Schiöler

Fell

et al. 2022

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose Obesity is a growing, global health problem and previous cross-sectional studies have demonstrated an association between obesity and chronic rhinosinusitis (CRS). There is, however, a lack of prospective studies regarding the impact of obesity on developing (new-onset) CRS. Methods Questionnaire-based data (n = 5769) relating to new-onset CRS and Body Mass Index (BMI) were collected in 2013 and 2018 from the Telemark population study in Telemark, Norway. Odds ratios for the risk of new-onset CRS in 2018 in relation to BMI in 2013 were calculated, adjusted for smoking habits, asthma, gender and age. Results When comparing the group with normal weight (18.5 ≤ BMI < 25) with the obese group (BMI ≥ 30), the odds of new-onset CRS was 53% higher [OR 1.53 (1.11, 2.10)] in the obese group. Conclusion CRS is a multifactorial disease with different phenotypes and it is important to consider obesity when assessing patients with CRS in a clinical setting.

show abstract

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

Cited by 19 publications

References 41 publications

Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis

Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis

Obesity and ENT manifestations — a tertiary care centre study

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

Contact Info

Product

Resources

About