The Association Between Obesity and Screening Mammography Accuracy

Elmore, Joann G.; Carney, Patricia A.; Abraham, Linn; Barlow, William E.; Egger, Joseph; Fosse, Jessica Scura; Cutter, Gary; Hendrick, R. Edward; D’Orsi, Carl J.; Paliwal, Prashni; Taplin, Stephen H.

doi:10.1001/archinte.164.10.1140

Cited by 83 publications

(53 citation statements)

References 27 publications

(24 reference statements)

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“…Mammography has the same sensitivity regardless of BMI, but lower specificity for obese women, [27] and such differences are not likely to explain the results in the present study.…”

Section: The Mammographic Screening Statuscontrasting

confidence: 53%

See 1 more Smart Citation

Body mass index and breast cancer survival in relation to the introduction of mammographic screening

Olsson

Garne²,

Tengrup

et al. 2009

European Journal of Surgical Oncology (EJSO)

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“…Mammography has the same sensitivity regardless of BMI, but lower specificity for obese women, [27] and such differences are not likely to explain the results in the present study.…”

Section: The Mammographic Screening Statuscontrasting

confidence: 53%

“…[12,[27][28][29][30][31] In this study we were able to investigate women invited to screening as a group which corresponds to an "intention-to-treat-approach". This may indeed be useful considering the impact of invitation to mammographic screening as a preventive tool.…”

Section: The Mammographic Screening Statusmentioning

confidence: 99%

Body mass index and breast cancer survival in relation to the introduction of mammographic screening

Olsson

Garne²,

Tengrup

et al. 2009

European Journal of Surgical Oncology (EJSO)

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“…Age and breast density are highly correlated, with breast density decreasing as women age (22). Overweight women tend to have less dense breasts (23). In our study, current statin use at the time of screening and any statin use during the study period was associated with having less dense breasts compared with nonusers even after adjusting for age, BMI, and hormone therapy use.…”

Section: Discussionmentioning

confidence: 43%

The Influence of Statin Use on Breast Density

Boudreau

Rutter

Buist

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objective: To evaluate if 3-hydroxy-3-methylglutaryl CoA reductase reductase inhibitor use (statins) alters mammography measured breast density. Methods: Cohort study of women ages 50 to 80 years with two mammography screenings. Changes in BI-RADS breast density between screenings was compared for nonusers, initiators, discontinuers, continuers, and any users of statins. Results: Statin use was not associated with increases or decreases in breast density compared with nonusers after adjusting for age, body mass index, change in body mass index, hormone therapy use, and time between screenings.Cumulative days of statin use during the year before screening was not associated with changes in breast density in any of the groups of statin users. When hormone therapy users were excluded, any statin use was associated with an increase in breast density compared with nonusers (odds ratio, 1.2; 95% confidence interval, 1.0-1.5). Conclusions: We found no association between statin use and change in breast density in general, but statin use may be associated with increases in breast density among nonusers of hormone therapy. (Cancer Epidemiol Biomarkers Prev 2006;15(5):1026 -9)

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“…The observation that the accuracy of a test varies across patient subgroups complicates the issue of patient selection in diagnostic accuracy studies (1)(2)(3). The typical approach is to include those patients who would also undergo the index test in the relevant clinical situation, to perform the index test, and then to verify the results for all patients with the reference standard.…”

mentioning

confidence: 99%

Case–Control and Two-Gate Designs in Diagnostic Accuracy Studies

Reitsma²,

et al. 2005

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Background:In some diagnostic accuracy studies, the test results of a series of patients with an established diagnosis are compared with those of a control group. Such case-control designs are intuitively appealing, but they have also been criticized for leading to inflated estimates of accuracy. Methods: We discuss similarities and differences between diagnostic and etiologic case-control studies, as well as the mechanisms that can lead to variation in estimates of diagnostic accuracy in studies with separate sampling schemes ("gates") for diseased (cases) and nondiseased individuals (controls). Results: Diagnostic accuracy studies are cross-sectional and descriptive in nature. Etiologic case-control studies aim to quantify the effect of potential causal exposures on disease occurrence, which inherently involves a time window between exposure and disease occurrence. Researchers and readers should be aware of spectrum effects in diagnostic case-control studies as a result of the restricted sampling of cases and/or controls, which can lead to changes in estimates of diagnostic accuracy. These spectrum effects may be advantageous in the early investigation of a new diagnostic test, but for an overall evaluation of the clinical performance of a test, case-control studies should closely mimic cross-sectional diagnostic studies. Conclusions: As the accuracy of a test is likely to vary across subgroups of patients, researchers and clinicians might carefully consider the potential for spectrum

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The Association Between Obesity and Screening Mammography Accuracy

Abstract: Obese women had more than a 20% increased risk of having false-positive mammography results compared with underweight and normal weight women, although sensitivity was unchanged. Achieving a normal weight may improve screening mammography performance.

Cited by 83 publications

References 27 publications

Body mass index and breast cancer survival in relation to the introduction of mammographic screening

Body mass index and breast cancer survival in relation to the introduction of mammographic screening

The Influence of Statin Use on Breast Density

Case–Control and Two-Gate Designs in Diagnostic Accuracy Studies

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