The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population

Wu, Yongwei; Zhu, Zhiling; Fang, Xiaoxia; Yin, Ling; Liu, Yuxia; Xu, Shouxia; Li, Aixue

doi:10.1155/2016/1957374

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…According to the results, the distribution of NOS3 SNV rs2070744 significantly varied in children with different Apgar scores (≤5, TT/TC/CC = 6/7/5; 6-7, TT/TC/CC = 17/0/0; 8-9, TT/TC/CC = 6/2/0; 10, TT/TC/CC = 7/1/0; p = 0.006). Thus, the NOS3 SNV rs2070744 (p = 0.026) was associated with a high susceptibility to HIE [68].…”

Section: Hypoxic-ischemic Encephalopathy (Hie)mentioning

confidence: 94%

Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders

Насырова

Moskaleva

Vaiman

et al. 2020

IJMS

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According to the recent data, nitric oxide (NO) is a chemical messenger that mediates functions such as vasodilation and neurotransmission, as well as displaying antimicrobial and antitumoral activities. NO has been implicated in the neurotoxicity associated with stroke and neurodegenerative diseases; neural regulation of smooth muscle, including peristalsis; and penile erections. We searched for full-text English publications from the past 15 years in Pubmed and SNPedia databases using keywords and combined word searches (nitric oxide, single nucleotide variants, single nucleotide polymorphisms, genes). In addition, earlier publications of historical interest were included in the review. In our review, we have summarized information regarding all NOS1, NOS2, NOS3, and NOS1AP single nucleotide variants (SNVs) involved in the development of mental disorders and neurological diseases/conditions. The results of the studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, and different social and geographical characteristics. However, the contribution of genetic and environmental factors has been understudied, which makes this issue increasingly important for researchers as the understanding of these mechanisms can support a search for new approaches to pathogenetic and disease-modifying treatment.

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Section: Hypoxic-ischemic Encephalopathy (Hie)mentioning

confidence: 94%

Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders

Насырова

Moskaleva

Vaiman

et al. 2020

IJMS

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“…MTHFR polymorphisms were also proposed as biomarkers of brain injury determined using MRI or other imaging methods [ 28 , 29 , 30 ]. Among genes associated with inflammation and oxidative stress, only NOS3 polymorphisms were associated with brain injury on MRI after HIE [ 31 , 32 ], but in these studies, the MRI classification was performed only at two years of age. The association between genetic variability of inflammatory and antioxidant genes and early MRI findings has not been addressed yet.…”

Section: Introductionmentioning

confidence: 99%

CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia

et al. 2021

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Inflammation and oxidative stress are recognized as important contributors of brain injury in newborns due to a perinatal hypoxic-ischemic (HI) insult. Genetic variability in these pathways could influence the response to HI and the outcome of brain injury. The aim of our study was to evaluate the impact of common single-nucleotide polymorphisms in the genes involved in inflammation and response to oxidative stress on brain injury in newborns after perinatal HI insult based on the severity and pattern of magnetic resonance imaging (MRI) findings. The DNA of 44 subjects was isolated from buccal swabs. Genotyping was performed for NLRP3 rs35829419, CARD8 rs2043211, IL1B rs16944, IL1B rs1143623, IL1B rs1071676, TNF rs1800629, CAT rs1001179, SOD2 rs4880, and GPX1 rs1050450. Polymorphism in CARD8 was found to be protective against HI brain injury detected by MRI overall findings. Polymorphisms in IL1B were associated with posterior limb of internal capsule, basal ganglia, and white matter brain patterns determined by MRI. Our results suggest a possible association between genetic variability in inflammation- and antioxidant-related pathways and the severity of brain injury after HI insult in newborns.

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“…The possible role of NOS3 variants on the risk for neurological diseases has been the matter of several recent reports. In this regard, it has been reported an increased risk for delayed cerebral ischemia following aneurismal subarachnoid hemorrhage ( Hendrix et al, 2017 ) and hypoxic-ischemic encephalopathy ( Wu et al, 2016 ). One study in the Iranian population showed an association between NOS3 rs2070744 and multiple sclerosis ( Heidari et al, 2017 ), but this association was not replicated in other populations ( AlFadhli et al, 2013 ; Agúndez et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome

Jiménez‐Jiménez

Agúndez²,

Gómez-Tabales³

et al. 2021

Front. Pharmacol.

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Because nitric oxide and endothelial dysfunction could play a role in the pathogenesis of idiopathic restless legs syndrome (RLS), as was suggested by some preliminary data, we investigated the possible association between the rs2070744 variants in the endothelial nitric oxide synthase (eNOS or NOS3) gene (chromosome 7q36.1) and the risk for RLS in a Caucasian Spanish population. We assessed the frequencies of NOS3 single nucleotide polymorphisms (SNPs) rs2070744, rs1799983, and rs79467411 genotypes and allelic variants in 273 patients with idiopathic RLS and 325 healthy controls using a TaqMan-based qPCR assay. We also analyzed the possible influence of genotype frequency on age at onset of RLS symptoms, gender, family history of RLS, and response to drugs commonly used in the treatment of RLS such as dopaminergic drugs, clonazepam, and GABAergic drugs. The frequencies of genotypes and allelic variants were not associated with the risk for RLS and were not influenced by gender, age, and positive family history of RLS. We identified weak statistical associations of the SNP rs1799983 with the response to dopamine agonists (Pc = 0.018 for the rs1799983 G/T genotype) and of the SNP rs79467411 with the response to clonazepam (Pc = 0.018 for the rs79467411 G allele), although these findings should be cautiously interpreted and require further confirmation. These associations aside, our findings suggest that common NOS3 SNPs are not associated with the risk for idiopathic RLS in Caucasian Spanish people.

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The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population

Cited by 11 publications

References 34 publications

Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders

Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders

CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia

Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome

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