Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders

Насырова, Р. Ф.; Moskaleva, Polina; Vaiman, Elena E.; Shnayder, Natalia A.; Blatt, Nataliya L.; Rizvanov, Albert A.

doi:10.3390/ijms21051604

Cited by 26 publications

(32 citation statements)

References 68 publications

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“…RNS are derived from nitric oxide (NO) and superoxide anion (O 2 −• ) produced by nitric oxide synthetase 2 (NOS2), NADPH oxidase, XO, LOX, and COX, among others [ 113 , 114 ]. At physiological concentrations, a gaseous molecule nitric oxide (NO) is a second messenger involved in blood pressure regulation, smooth muscle relaxation, defense mechanisms, immune regulation, and neurotransmission contributing the function of memory and learning [ 47 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

“…In response to bacterial lipopolysaccharides and inflammatory stimuli, i NOS generates nitric oxide (NO) that protects tissue hypoxia and serves as a neurotransmitter. However, overexpression i NOS, increase of nitric oxide (NO), and subsequent inflammation have been implicated in pathophysiology of neurodegenerative diseases including MS [ 47 ]. Calmodulin mediates the oxidative stress and inflammasome activation involving calmodulin-binding proteins, calcineurin, and calcium/calmodulin-dependent kinase II.…”

Section: Oxidative Stressmentioning

confidence: 99%

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Monitoring the Redox Status in Multiple Sclerosis

Tanaka

Vécsei

2020

Biomedicines

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Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms, including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients provide evidence on the disturbance of reduction-oxidation (redox) homeostasis, such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discusses the components of redox homeostasis, including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species cover frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive, as well as pro-oxidative stressors. The antioxidative enzyme systems cover the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring the battery of reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products helps to evaluate the redox status of MS patients to expedite the building of personalized treatment plans for the sake of a better quality of life.

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Section: Oxidative Stressmentioning

confidence: 99%

Section: Oxidative Stressmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka

Vécsei

2020

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Superoxide (O2 −• ) is possibly produced in the acidic environment which favors dismutation of hydrogen peroxide (H2O2) into hydroxy radical (OH • ) by ferrous iron [75]. Furthermore, ozone (O3) and ozone-like oxidants are generated from singlet oxygen (O2 and neurotransmission contributing the function of memory and learning [79].…”

Section: Immunomodulators Interferon Beta (Ifn-β) Cismentioning

confidence: 99%

“…iNOS and subsequent increase of nitric oxide (NO) has been implicated in pathophysiology of neurodegenerative diseases including MS [79]. The iNOS activity is upregulated in acute MS plaques [19,95].…”

Section: Immunomodulators Interferon Beta (Ifn-β) Cismentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka¹,

Vécsei²

2020

Preprint

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Worldwide, over 2.2 million people are suffered from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients evidenced the disturbance of reduction-oxidation (redox) homeostasis such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discussed the components of redox homeostasis including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species covered frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive as well as pro-oxidative stressors. The antioxidative enzyme systems covered the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring a battery of reactive chemical species, oxidative enzymes, antioxidative enzymes and degradation products helps evaluate the redox status of MS patients to expedite building personalized treatment plans for the sake of better quality of life.

show abstract

“…In response to bacterial lipopolysaccharides and inflammatory stimuli, iNOS generates nitric oxide (NO) that protects tissue hypoxia and serves as a neurotransmitter. However, overexpression iNOS and subsequent increase of nitric oxide (NO) has been implicated in pathophysiology of neurodegenerative diseases including MS [75]. The iNOS activity is upregulated in acute MS plaques [17,91].…”

Section: -Oh2dgmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka¹,

Vécsei²

2020

Preprint

View full text Add to dashboard Cite

Worldwide, over 2.2 million people are suffered from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by multifocal inflammatory or demyelinating attacks associated with neuroinflammation and neurodegeneration. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients evidenced the disturbance of reduction-oxidation (redox) homeostasis such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discussed the components of redox homeostasis including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species covered frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive as well as pro-oxidative stressors. The antioxidative enzyme systems covered the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring a battery of reactive chemical species, oxidative enzymes, antioxidative enzymes and degradation products helps evaluate the redox status of MS patients, expediting prolongation of remission, prevention of relapse, and thus building personalized treatment plans.

show abstract

Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders

Cited by 26 publications

References 68 publications

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

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