The association between migraine and restless legs syndrome: an updated systematic review and meta-analysis

Wang, Jing; Gao, Yu; Liu, Lin; Xu, Weihao; Zhang, Pei‐Cheng; Liu, Yu; Qian, Xiaoshun; Yu, Shengyuan

doi:10.1016/j.sleep.2019.01.027

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…36 Furthermore, individuals with migraine and RLS reportedly have more severe symptoms of anxiety and depression and higher BDI total scores than those without RLS. 6,7,22 The findings of this study suggest that individuals with migraine and RLS are more likely to have sleep disturbance and emotional disorders than those without RLS. Multivariate regression analysis showed that one SNP (rs79004933) was correlated with the BDI score in patients with migraine and RLS.…”

Section: Discussionmentioning

confidence: 68%

“…Nevertheless, our data for the relationship between RLS, migraine, and depression were in accordance with a recent literature review. 6 Finally, the cohort sample was relatively modest. However, this drawback could be offset by the precise diagnostic methods used.…”

Section: Discussionmentioning

confidence: 99%

“…An updated systematic review and meta-analysis demonstrated that patients with comorbid migraine had more severe symptoms of RLS. 6 Although the exact mechanisms of the association between migraine and RLS are not clearly understood, several lines of evidence suggest that RLS and migraine might share some clinical features and an underlying pathophysiology. Disturbance of iron metabolism and dopaminergic dysfunction have been identified in both conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Although Lucchesi et al found that RLS was more common in individuals with chronic migraine (CM) than in those with episodic migraine (EM), no conclusions can be drawn based on the limited data currently available. 6,8 Similarly, Bilgehan et al found that migraine, particularly migraine with aura (MA), was more common in patients with RLS 9 ; however, d'Onofrio et al did not. 10 Therefore, the relationship between MA/migraine without aura (MoA) and RLS has not been confirmed.…”

Section: Introductionmentioning

confidence: 98%

“…5 A systematic review found that RLS was more common in migraineurs (17.0%) than in nonmigraineurs (7.0%). 6 Suzuki et al reported that migraineurs with RLS had higher Migraine Disability Assessment (MIDAS) scores and poorer sleep quality with more symptoms of depression than their counterparts without RLS. 7 Migraine and RLS may share some common pathophysiological mechanisms involving dopaminergic dysfunction and disturbed iron metabolism and have known genetic risk factors.…”

Section: Introductionmentioning

confidence: 99%

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Association of genetic variants in migraineurs with and without restless legs syndrome

Lin

Liang

et al. 2020

Ann Clin Transl Neurol

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Objective: Several single-nucleotide polymorphisms (SNPs) are associated with restless legs syndrome (RLS). This study investigated whether or not additional SNP variants increase the risk of RLS in migraineurs and in migraine with aura (MA) and migraine without aura (MoA) subgroups. Methods: Migraineurs with and without RLS were genotyped using an Affymetrix array. We performed association analyses for the entire cohort and the MA and MoA subgroups, which were divided further into episodic migraine (EM) and chronic migraine (CM). Potential correlations between SNPs and clinical indices in migraineurs with RLS were examined by multivariate regression analysis. Results: The rs77234324 and rs79004933 SNPs were found in migraineurs with (P = 2.57E-07) and without (P = 3.03E-07) RLS. The A allele frequency for rs77234324 (on LGR6) was 0.1321 in migraineurs with RLS and 0.0166 in those without RLS (odds ratio, 8.978). The T allele frequency for rs79004933 (in the intergenic region) was 0.1981 in migraineurs with RLS and 0.0446 in those without (odds ratio, 5.281). rs2858654, rs76770509, rs4243475 in UTRN, rs150762626, and rs2668375 were identified in migraine with and without RLS in the MoA subgroup (P = 7.56E-09, P = 2.30E-08, P = 1.19E-07, P = 6.86E-07, and P = 8.05E-07, respectively). There was a suggestion of an association between rs10510331 (P = 1.50E-06) and CM and EM in patients with MoA and RLS. Multivariate regression showed a significant relationship between rs79004933 and the Beck Depression Inventory score. Interpretation: rs77234324 in LGR6 and rs79004933 in the intergenic region were associated with RLS in migraineurs. Five SNPs increased the risk of RLS in patients with MoA.

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