The Association Between Metabolic Syndrome and Colorectal Neoplasm

Abstract

Background There has been constant speculation about the association between metabolic syndrome (MetS) and colorectal neoplasia (CN); however, the published results are conflicting. The aims of this study are to systematic search, and assess literature to determine the available evidence on the association between these two conditions. Methods Meta-analysis was conducted based on relevant studies identified through a systematic literature review from PubMed, OvidSP and Cochrane database during January 1980 to July 2011. A combined analysis was performed, followed by a subgroup analyses stratified by the study design, type of colorectal lesions and gender. Publication bias was assessed using the Begg’s and Egger’s tests and visual inspection of funnel plot. Results Eighteen studies were included in the final analysis. Overall, MetS was associated with 34% increase in the risk of CN (summary RR - 1.34, 95% CI 1.24–1.44). The association between MetS and CN was found to be statistically significant in separate analysis for both case-control studies (summary RR -1.58, 95% CI 1.44–1.79) and cohort studies (summary RR – 1.21, 95% CI 1.13–1.29). The association remained significant when analyses were restricted by type of colorectal lesions (colorectal cancer: RR – 1.30, 95% CI 1.18–1.43; colorectal adenoma: RR – 1.37, 95% CI 1.26–1.49). Further subgroup analysis by gender showed significant association between MetS and CN in both male and female population. Conclusion Our meta-analysis showed significant association between presence of MetS and CN. These results may help in identifying high risk individuals at early stage that might benefit from targeted CRC screening intervention.

Submucosal fat accumulation in human colorectal tissue and its association with abdominal obesity and insulin resistance

“…[2][3][4][5] MetS is also shown to be associated with an increased risk of colorectal cancer incidence and mortality in both sexes. 6,7 We also have shown that increasing the area of visceral fat assessed with computed tomography (CT) scans and a decreased concentration of plasma adiponectin are associated with the development of colorectal cancer and also adenoma, which is its precursor lesion. 8,9 Hyperinsulinaemia due to insulin resistance and its influence in enhancing free or bioavailable concentrations of insulin-like growth factor-1, and altered levels of adipokines and their contribution to chronic low-grade inflammation are suggested to play a pivotal role in increasing colorectal cancer risk.…”

The metabolic syndrome as a risk factor for colorectal cancer

“…Результаты метаанализов подтверждают ассоци-ацию наличия МС с повышенным риском развития КРР [28,29,30] ; ≥3 критериев против <3 критериев), значимость связи нивелировалась в мультивариантной модели. В данном исследовании также не обнаружили связи МС с КРР как у мужчин, так и у женщин (RR=1,34; 95% CI: 0,9-2,0 и RR=1,34; 95% CI: 0,9-2,1 соответ-ственно) [11].…”

Awareness of breast cancer among rural residents

“…dokonali analizy badań zamieszczonych w bazie Pub Med, OvidSP i Cochrane w latach 1980-2011. Oszacowali, że zespół metaboliczny wiązał się z istotnie wyższym ryzykiem zachorowania na raka jelita grubego [7]. Klimczak i wsp.…”