Submucosal fat accumulation in human colorectal tissue and its association with abdominal obesity and insulin resistance

Wada, Sanehiro; Yasunaga, Yuichi; Oka, Kunihiro; Dan, Naoki; Tanaka, Eri; Morita, Kiyozo; Masuda, Eriko; Yanagawa, Kazunori; Matsumoto, Hitoshi; Yoshioka, Shinichi; Tomita, Masaki; Inui, Yoshiaki; Kawata, Satoshi

doi:10.1177/2050640618766926

Cited by 13 publications

(7 citation statements)

References 25 publications

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“…Using GTEx’s histology data we were able to elucidate an association between ADIPOQ , a gene decreasing with age in multiple tissues, and loss of fat in the CLNTRN sub-mucosal space. Our findings are inconsistent with other literature stating that inter-mucosal fat increases with BMI [30] and does not decrease with age [31]. However our data differs from theirs in several regards.…”

Section: Discussioncontrasting

confidence: 99%

Sex, age, tissue, and disease patterns of matrisome expression in GTEx transcriptome data

Nieuwenhuis

Rosenberg

McCall

et al. 2021

Preprint

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The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues, were obtained from the Genotype-Tissue Expression (GTEx) project. Additional datasets were obtained from The Cancer Genome Atlas (TCGA) program and the Gene Expression Omnibus for comparisons. Gene expression levels generally recapitulated proteome-derived matrisome expression patterns. Further, matrisome gene expression properly clustered tissue types, with some matrisome genes including SERPIN family members having tissue-restricted expression patterns. Deeper analyses revealed 388 genes varied by age and 222 varied by sex in at least one tissue, with expression correlating with digitally imaged histologic tissue features. A comparison of TCGA tumor, TCGA adjacent normal and GTEx normal tissues demonstrated robustness of the GTEx samples as a generalized control, while also determining a common primary tumor matrisome. Additionally, GTEx tissues served as a useful non-diseased control in a separate study of idiopathic pulmonary fibrosis matrix changes. Altogether, these findings indicate that the transcriptome, in general, and GTEx in particular, has value in understanding the state of organ ECM.

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Section: Discussioncontrasting

confidence: 99%

Sex, age, tissue, and disease patterns of matrisome expression in GTEx transcriptome data

Nieuwenhuis

Rosenberg

McCall

et al. 2021

Preprint

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“…Visceral fat can secrete tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1 and other proinflammatory factors to promote the onset and development of insulin resistance. 28 However, the VFA does not reflect fat accumulation in the liver, skeletal muscle, 29 submucosa of the intestinal wall, 30 or even astrocytes. 31 This ectopic fat accumulation can also lead to the development of insulin resistance and affect blood glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Changes in Body Composition After 3 Months of Dulaglutide Treatment

Chen,

Wang,

Jin

et al. 2024

DMSO

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Background Changes in body composition accompanied by glucagon-like peptide 1 receptor agonist (GLP-1RA) induced weight loss have drawn much attention. However, fewer studies have reported body composition changes in patients receiving dulaglutide therapy in Chinese population. Methods A total of 70 overweight/obese type 2 diabetes mellitus (T2DM) patients who received dulaglutide therapy were included. Clinical data were collected. Visceral fat area (VFA) and body composition were also measured. Changes in clinical indicators and body composition of patients before and after intervention were also analyzed. Correlation analysis and multiple linear regression model were used to evaluate the association between hemoglobin A1C (HbA1c) and body composition. Results The results showed that body weight (BW), VFA, body fat (BF), lean body mass (LBM), skeletal muscle mass (SMM) and water content were reduced after 3 months dulaglutide intervention. The lean body mass percentage (LBMP) and skeletal muscle mass percentage (SMMP) significantly increased. Moreover, there was no significant difference in bone mineral quality (BMQ) after the intervention. The multiple linear regression model revealed that the % change in BF was independently associated with % change in HbA1c (β = 0.449, t = 3.148, p=0.002). Conclusion These results indicate that dulaglutide intervention does not cause muscle and bone mass loss while inducing weight loss, and % change in BF was independently associated with improved glucose control during dulaglutide therapy. This study offers some positive results to support the clinical application of dulaglutide.

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“…The grade of lipid droplet accumulation was significantly associated with BMI, waist circumference and visceral fat. This study showed the presence of submucosal fat accumulation in human colorectal tissue in association with abdominal obesity and insulin resistance [11]. It is important to note that systemic reviews and meta-analyses of studies involving several ethnic groups provide robust statistical evidence on the superiority of WHtR over waist circumference and BMI for detecting cardiometabolic risk factors in both genders [26–28].…”

Section: Discussionmentioning

confidence: 99%

“…The ability to directly visualize the submucosa with advanced endoscopic techniques has facilitated the analysis of submucosal fatty tissue and its possible relationship with metabolic syndrome or its components such as abdominal obesity. Despite this, there are still limited descriptions of this phenomenon in the endoscopic literature [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The impact of submucosal fatty tissue during colon endoscopic submucosal dissection in a western center

Zabala

Parra‐Blanco

Beg

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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Objectives Obesity is associated with submucosal fatty tissue. The main aim of this study was to assess the impact of submucosal fatty tissue on the success of colonic endoscopic submucosal dissection (C-ESD) in a western population. Methods This was a retrospective analysis of 125 consecutive C-ESDs performed between October 2015 and July 2017. Fatty tissue sign was defined as positive when the submucosal layer was covered with fatty tissue. The complexity of performing an ESD was assessed by the performing endoscopist, defined by the occurrence of intraprocedural perforation, inability to complete an en-bloc resection or a procedure time exceeding 180 min. Results Fatty tissue sign positive was present in 44.8% of the procedures. There were 28 (22.4%) c-ESD defined as complex. Factors associated with complex ESD included; fatty tissue sign [odds ratio (OR) 12.5; 95% confidence interval (CI), 1.9–81.9; P = 0.008], severe fibrosis (OR 148.6; 95% CI, 6.6–3358.0; P = 0.002), poor maneuverability (OR 267.4; 95% CI, 11.5–6212.5; P < 0.001) and polyp size ≥35 mm (OR 17.2; 95% CI, 2.6–113.8; P = 0.003). In patients demonstrating the fatty tissue sign, BMI and waist-to-height ratio (WHtR) were higher (27.8 vs. 24.7; P < 0.001 and 0.56 vs. 0.49; P < 0.001, respectively) and en-bloc resection was achieved less frequently (76.8 vs. 97.1%, P = 0.001). Multivariate analysis revealed higher risk of fatty tissue sign positive associated with WHtR ≥0.52 (OR 26.10, 95% CI, 7.63–89.35, P < 0.001). Conclusion This study demonstrates that the fatty tissue sign contributes to procedural complexity during C-ESD. Central obesity correlates with the likelihood of submucosal fatty tissue and as such should be taken into account when planning procedures.

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Submucosal fat accumulation in human colorectal tissue and its association with abdominal obesity and insulin resistance

Cited by 13 publications

References 25 publications

Sex, age, tissue, and disease patterns of matrisome expression in GTEx transcriptome data

Sex, age, tissue, and disease patterns of matrisome expression in GTEx transcriptome data

Assessment of Changes in Body Composition After 3 Months of Dulaglutide Treatment

The impact of submucosal fatty tissue during colon endoscopic submucosal dissection in a western center

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