The Association between Medical History-based Risks and Sepsis Events in Immunocompromised Patients according to Type III Stratification of the Indonesian Regulation on the Prospective Antimicrobial System (Regulasi Antimikroba Sistem Prospektif / RASPRO)

Abstract

Background: The Indonesian Regulation on the Prospective Antimicrobial System (Regulasi Antimikroba Sistem Prospektif / RASPRO) is a novel program. Its role has been reinforced by the Indonesian Ministry of Law and Human Rights Stipulation, which may predict the risk of sepsis events. Our study aimed to evaluate whether the risk factors listed in the RASPRO consensus have actual effects on sepsis events.Method: The study was a retrospective cohort using secondary data with 98 subjects. The subjects were categorized into two groups, i.e., the RASPRO group with type III stratification (RASPRO Group) and Non-type III stratification RASPRO group (Non-RASPRO Group). Subjects with infection but with conditions other than the abovementioned criteria were categorized into the Non-RASPRO group.Results: We found that among subjects in the RASPRO group, a history of antibiotic use over the past <30 days (OR 3.42; 95%CI 1.32–8.85; p=0.011) and a history of having procedure using medical instruments within the last <30 days (OR 2.62; 95%CI 1.06–6.45; p=0.037) seemed to be greatest risk factors for sepsis events.Conclusion: The RASPRO group has a higher risk for sepsis events than the non-RASPRO with a history of antibiotic undergoing a procedure using a medical instrument within the last <30 days possessed the greatest risk factors for sepsis events.