The Association Between Maternal Age and Cerebral Palsy Risk Factors

Schneider, Rilla E.; Ng, Pamela; Zhang, Xun; Andersen, John; Buckley, David; Fehlings, Darcy; Kirton, Adam; Wood, Ellen; Rensburg, Esias van; Shevell, Michael; Oskoui, Maryam

doi:10.1016/j.pediatrneurol.2018.01.005

Cited by 22 publications

(16 citation statements)

References 20 publications

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“…3 This group is potentially one of the most difficult to engage in health promotion. Our mediation analysis indicated that being an adolescent mother conferred its own risk, which may include increased risk of congenital anomalies, 28 risky behaviour during pregnancy, a lack of support, and barriers to accessing antenatal services.…”

Section: Discussionmentioning

confidence: 93%

Impact of social disadvantage on cerebral palsy severity

Woolfenden

Galea

Smithers‐Sheedy

et al. 2018

Develop Med Child Neuro

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Section: Discussionmentioning

confidence: 93%

Impact of social disadvantage on cerebral palsy severity

Woolfenden

Galea

Smithers‐Sheedy

et al. 2018

Develop Med Child Neuro

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“…For example, a causal pathway may involve increased risk for placental abruption in multiple births, 29 which in turn may contribute to preterm birth 30 and CP. 11 31 Advanced maternal age 32 and assisted reproductive technologies (ARTs) 33 may also confound the association between multiple birth and CP. 34…”

Section: Discussionmentioning

confidence: 99%

Decreasing cerebral palsy prevalence in multiple births in the modern era: a population cohort study of European data

Perra¹,

Rankin

Platt

et al. 2020

Arch Dis Child Fetal Neonatal Ed

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Multiple births (twins or higher order multiples) are increasing in developed countries and may present higher risk for cerebral palsy (CP). However, few studies can reliably investigate trends over time because these outcomes are relatively rare.ObjectiveWe pooled data from European CP registers to investigate CP birth prevalence and its trends among single and multiple births born between 1990 and 2008.DesignPopulation cohort study.Setting12 population-based registers from the Surveillance of Cerebral Palsy in Europe collaboration.Participants4 446 125 single and multiple live births, of whom 8416 (0.19%) had CP of prenatal or perinatal origin.Main outcomesCP diagnosis ascertained in childhood using harmonised methods; CP subtype; Motor impairment severity among CP cases.ResultsThe rate of multiple births increased from 1990. Multiples displayed higher risk for CP (RR=4.27, 95% CI 4.00 to 4.57). For singletons and multiples alike, risk for CP was higher among births of lower gestational age (GA) or birth weight (BW). However, CP birth prevalence declined significantly among very preterm (<32 weeks) and very low BW (<1500 g) multiples. Singletons and multiples with CP displayed similar severity of motor impairment.ConclusionsBetween 1990 and 2008, CP birth prevalence decreased steadily among multiples with low GA or BW. Furthermore, multiples with CP display similar profiles of severe motor impairment compared with CP singletons. Improvements in management of preterm birth since the 1990s may also have been responsible for providing better prospects for multiples.

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“…Data collected includes sociodemographic features, CP risk factors (antepartum, intrapartum, and postpartum), and CP phenotypic profile (functional status and comorbidities). 7 -9…”

Section: Methodsmentioning

confidence: 99%

“…Data collected includes sociodemographic features, CP risk factors (antepartum, intrapartum, and postpartum), and CP phenotypic profile (functional status and comorbidities). [7][8][9] Canadian CP Registry participants from the province of Quebec born between 1999 and 2010 were included in this analysis. Birth years were categorized for comparison into successive consecutive nonoverlapping intervals of 3 years (ie, 1999-2001, 2002-2004, 2005-2007, and 2008-2010).…”

Section: Data Sourcementioning

confidence: 99%

Is Cerebral Palsy Changing in High Resource Settings? Data From the Quebec Cerebral Palsy Registry

Hadjinicolaou

Zhang

et al. 2019

J Child Neurol

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Advances in maternal and perinatal care in developed countries have led to improved health outcomes for children. These changes may have impacted the profile of children with a cerebral palsy (CP) and groups at risk for CP over time. Using data from the Canadian CP Registry, the objectives of this retrospective cohort study were to describe the profile of children with CP in Quebec born between 1999 and 2010 and identify possible temporal variation in CP risk factors and phenotypic profile. Our sample consisted of 662 children with CP in Quebec. No change in profile or associated risk factors was observed across the birth cohorts 1999 to 2010. Prematurity remains the largest risk factor for CP in Quebec, and children with CP have multiple comorbidities that contribute to overall CP burden. CP registries offer a unique platform to study spectrum disorders and their longitudinal changes over time.

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The Association Between Maternal Age and Cerebral Palsy Risk Factors

Cited by 22 publications

References 20 publications

Impact of social disadvantage on cerebral palsy severity

Impact of social disadvantage on cerebral palsy severity

Decreasing cerebral palsy prevalence in multiple births in the modern era: a population cohort study of European data

Is Cerebral Palsy Changing in High Resource Settings? Data From the Quebec Cerebral Palsy Registry

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