The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females

Zhao, Jun; Zhang, Xu; Guan, Ting; Dai, Qi; He, Wenshan; Zhang, Honggang; Wang, Yuanyuan; Wang, Bei; Peng, Zuoqi; Xu-huai, HU; Qi, Daxun; Yang, Xueying; Zhang, Yue; Ma, Xu

doi:10.1038/s41598-019-40354-7

Cited by 4 publications

(4 citation statements)

References 26 publications

(44 reference statements)

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“…The NFPCP is a nationwide, population‐based study project aimed at providing free pre‐pregnancy medical examinations for general reproductive‐age couples (not just those with fertility problems) who have made their conception plan in 6 months to improve their reproductive health 18 . This study was an original research based on the NFPCP, and the data were obtained from the NFPCP system.…”

Section: Methodsmentioning

confidence: 99%

“…The NFPCP is a nationwide, population-based study project aimed at providing free pre-pregnancy medical examinations for general reproductive-age couples (not just those with fertility problems) who have made their conception plan in 6 months to improve their reproductive health. 18 This study was an original research based on the NFPCP, and the data were obtained from the NFPCP system. From January 1, 2013 to December 31, 2018, comprising 268 627 males aged 18-65 years participated in the NFPCP and completed prepregnancy eugenic health examinations in Shenzhen, China.…”

Section: Design and Study Populationmentioning

confidence: 99%

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Association between body mass index and varicocele among 211 989 Chinese reproductive‐age males

Xu-huai¹,

Yang

Zhao

et al. 2022

Int J of Urology

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Objectives: To explore the relationship between body mass index and varicocele, the range of body mass index that leads to increased odds of varicocele, and the association between body mass index with the position and grade of varicocele. Methods: We conducted a cross-sectional study of 211 989 Chinese males aged 18-65 years participated in the National Free Pre-conception Check-up Projects from January 2013 to December 2018. Univariate and multivariate logistic regression models were constructed to assess the association between body mass index and varicocele. Results: Overweight and obese males had 13.1% (odds ratio 0.869, 95% confidence interval 0.838-0.902) and 32.3% (odds ratio 0.677, 95% confidence interval 0.632-0.725) lower odds of varicocele than those with normal body mass index, respectively. The association between them was non-linear, and males with body mass index of 17.74 to 23.09 kg/m 2 had an increased odds of varicocele. The overweight and obese males had lower odds of left and bilateral varicocele, but the right varicocele odds was increased by 63.3% in obese males. Conclusion: Body mass index was associated with the odds of varicocele among reproductive-age males, but the odds varied by position. The effects of weight management and varicocele on fertility should be taken into account in fertility guidance.

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Section: Methodsmentioning

confidence: 99%

Section: Design and Study Populationmentioning

confidence: 99%

Association between body mass index and varicocele among 211 989 Chinese reproductive‐age males

Xu-huai¹,

Yang

Zhao

et al. 2022

Int J of Urology

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“…As a corollary, in response to oxidant stress, G6PD-deficient hepatocytes exhibit transcriptomic network perturbations in redox pathways and immune response pathways ( 98 ). Clinically, G6PD deficiency has been linked to increased risk of Hepatitis A and B infections ( 99 , 100 ), which may be related to deficient interferon responses in hepatocytes due to insufficient ROS generation by NADPH oxidase, as has been described for Dengue virus infection in G6PD-deficient monocytes ( 101 ).…”

Section: The Effect Of G6pd In Other Cell Types Important For Immunitymentioning

confidence: 99%

The global role of G6PD in infection and immunity

Shah,

Stone,

Francis

et al. 2024

Front. Immunol.

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. G6PD is an essential enzyme in the pentose phosphate pathway (PPP), generating NADPH needed for cellular biosynthesis and reactive oxygen species (ROS) homeostasis, the latter especially key in red blood cells (RBCs). Beyond the RBC, there is emerging evidence that G6PD exerts an immunologic role by virtue of its functions in leukocyte oxidative metabolism and anabolic synthesis necessary for immune effector function. We review these here, and consider the global immunometabolic role of G6PD activity and G6PD deficiency in modulating inflammation and immunopathology.

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“…Viral infections, including COVID-19 G6PD def may increase cell susceptibility to viral infections such as hepatitis B [16], dengue fever, enterovirus 71, and coronavirus 229E [11]. Additionally, viral infections may trigger hemolytic complications in G6PD def patients [17][18][19].…”

Section: Effect Of G6pd Def In Nonhemolytic Disordersmentioning

confidence: 99%

Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives

Garcia

Koperniku

Ferreira

et al. 2021

Trends in Pharmacological Sciences

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Glucose-6-phosphate dehydrogenase (G6PD) maintains redox balance in a variety of cell types and is essential for erythrocyte resistance to oxidative stress. G6PD deficiency, caused by mutations in the G6PD gene, is present in ~400 million people worldwide, and can cause acute hemolytic anemia. Currently, there are no therapeutics for G6PD deficiency. We discuss the role of G6PD in hemolytic and nonhemolytic disorders, treatment strategies attempted over the years, and potential reasons for their failure. We also discuss potential pharmacological pathways, including glutathione (GSH) metabolism, compensatory NADPH production routes, transcriptional upregulation of the G6PD gene, highlighting potential drug targets. The needs and opportunities described here may motivate the development of a therapeutic for hematological and other chronic diseases associated with G6PD deficiency. G6PD deficiency as a hematological disorderGlucose-6-phosphate dehydrogenase (G6PD; see Glossary) regulates glycolytic flux through the pentose phosphate pathway (PPP) and plays a central role in redox homeostasis; it produces NADPH, an essential cofactor for glutathione (GSH) regeneration. G6PD is a major source of NADPH and loss of G6PD function is detrimental in erythrocytes; it causes G6PD deficiency (G6PD def ), a potentially hemolytic disorder [1]. HighlightsGlucose-6-phosphate dehydrogenase (G6PD) deficiency is better known as a hematological disorder. However, G6PD may play a role in other chronic disorders such as diabetes, cardiovascular disease, viral infectivity and complications, and neurodegeneration.

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The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females

Cited by 4 publications

References 26 publications

Association between body mass index and varicocele among 211 989 Chinese reproductive‐age males

Association between body mass index and varicocele among 211 989 Chinese reproductive‐age males

The global role of G6PD in infection and immunity

Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives

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