Association between body mass index and varicocele among 211 989 Chinese reproductive‐age males

Xu-huai, HU; Yang, Xueying; Zhao, Jun; Guan, Ting; Dai, Qi; Yang, Juan; Zhang, Honggang; Zhang, Dongmei; Zhang, Yue; Li, Shang; Ma, Xu

doi:10.1111/iju.14915

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Similarly, whether or not obesity can increase the risk of varicocele has not been completely clarified. Accordingly, some studies have found a positive correlation between BMI and an increased varicocele risk, 94–96 other authors have reported no association or even a negative correlation 97–100 . Interestingly, however, Garolla et al 101 .…”

Section: Discussionmentioning

confidence: 98%

“…Accordingly, some studies have found a positive correlation between BMI and an increased varicocele risk, [94][95][96] other authors have reported no association or even a negative correlation. [97][98][99][100] Interestingly, however, Garolla et al 101 showed that both obesity and varicocele are associated with a significant increase in 24-h mean scrotal temperature when compared to controls. In addition, other authors have reported that obesity negatively affects varicocelectomy outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Does an increase in adipose tissue ‘weight’ affect male fertility? A systematic review and meta‐analysis based on semen analysis performed using the WHO 2010 criteria

et al. 2023

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IntroductionObesity negatively impact on the metabolism of sex hormones, leading to reduced testosterone serum levels. However, how the obesity could negatively impact on the overall gonadal function, particularly on male fertility, remained unclear so far.ObjectiveTo systematically review evidences regarding the influence of body weight excess on the sperm production.MethodsA meta‐analysis was conducted, searching all prospective and retrospective observational studies reporting male subjects older than 18 years old, with body weight excess from overweight to severe obesity were considered. Only studies using the V edition of the World Health Organization (WHO) manual for semen analysis interpretation were considered. No specific interventions were considered. Search was focused on studies comparing overweight/obese to normal weight subjects.ResultsTwenty‐eight studies were considered. Total sperm count and sperm progressive motility were significantly lower in overweight compared to normal weight subjects. Meta‐regression analyses demonstrated that patients’ age impacted on sperm parameters. Similarly, obese men showed lower sperm concentration, total sperm number, progressive and total motilities, and normal morphology lower than normal weight subjects. Reduced sperm concentration in obese men was influenced by age, smoking habit, varicocele, and total testosterone serum levels at meta‐regression analyses.ConclusionsThe male potential fertility is reduced in subjects with increased body weight, compared to normal weight men. The higher was the increased body weight, the worst was the sperm quantity/quality. This result comprehensively included obesity among non‐communicable risk factor for male infertility, shedding new lights on the negative impact of increased body weight on overall gonadal function.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Does an increase in adipose tissue ‘weight’ affect male fertility? A systematic review and meta‐analysis based on semen analysis performed using the WHO 2010 criteria

et al. 2023

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“…In addition, prevalence may have geographic differences in countries. Among 211,989 Chinese males of reproductive age and an average age of 31.20 years, a prevalence of 7.66% was observed [ 9 ]. There was an incidence of 15.7% in 7035 European young men with a median age of 19 years [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Scrotal Pain after Varicocelectomy: A Narrative Review

et al. 2023

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Varicocele is a frequently encountered urological disorder, which has a prevalence rate of 8 to 15% among healthy men. However, the incidence is higher in male patients with primary or secondary infertility, with up to 35 to 80% of varicocele cases occurring in this population. The clinical manifestations of varicocele typically include the presence of an asymptomatic mass that feels like a “bag of worms”, chronic scrotal pain, and infertility. Most patients with varicocele only undergo varicocelectomy after conservative treatments have failed. Unfortunately, some patients may still experience persistent scrotal pain due to a recurrence of varicocele, the development of hydrocele, neuralgia, referred pain, ureteral lesions, or nutcracker syndrome. Therefore, clinicians should consider these conditions as potential causes of postoperative scrotal pain, and take measures to address them. Several factors can assist in predicting surgical outcomes for patients with varicocele. Clinicians should consider these factors when deciding whether to perform surgery and what type of surgical intervention to use. By doing so, they can increase the likelihood of a successful surgical outcome and minimize the risk of complications such as postoperative scrotal pain.

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Semen parameter enhancement after varicocelectomy: Insights into varicose vein diameter and BMI influence: A cross-sectional study

Hariri,

Rajabalian,

Narouie

et al. 2024

Urologia

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Introduction: Varicocele is a condition in which the veins in the spermatic cord become enlarged and twisted. Varicocele is widely recognized as the leading cause of male infertility due to its significant impact on reproductive health in men. The aim of this study was to investigate the relationship between the diameter of the varicose vein and the recovery rate of the spermogram after varicocelectomy. Also, the effect of body mass index (BMI) on sperm parameters after varicocelectomy. Methods: This descriptive and analytical cross-sectional study was conducted in Valiasr Hospital’s urology clinic in Qaemshahr, Iran from August 2018 to August 2019 and involved 27 men with unilateral left varicocele who met the inclusion criteria for surgical repair. Before the operation, we recorded demographic information, the maximum diameter of varicose veins in the pampiniform plexus, and spermogram results. We repeated semen analysis 3 months after the operation and analyzed the data using Statistical Package for the Social Sciences version 21 software. Results: Our findings showed that the diameter of the varicose vein before varicocelectomy was not significantly associated with the improvement of main semen parameters after the operation. Furthermore, our study suggested that a lower body mass index might contribute to a greater improvement in sperm motility, as individuals with lower BMI showed more significant improvement. Discussion: There is a significant inverse relationship between BMI and sperm motility improvement after surgery. Patients with a lower BMI showed greater improvement in sperm motility.

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Association between body mass index and varicocele among 211 989 Chinese reproductive‐age males

Cited by 3 publications

References 27 publications

Does an increase in adipose tissue ‘weight’ affect male fertility? A systematic review and meta‐analysis based on semen analysis performed using the WHO 2010 criteria

Does an increase in adipose tissue ‘weight’ affect male fertility? A systematic review and meta‐analysis based on semen analysis performed using the WHO 2010 criteria

Scrotal Pain after Varicocelectomy: A Narrative Review

Semen parameter enhancement after varicocelectomy: Insights into varicose vein diameter and BMI influence: A cross-sectional study

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