The Association between Labor Induction and Autism Spectrum Disorders Among Children: A Meta-Analysis

Bashirian, Saeed; Seyedi, Mahdieh; Razjouyan, Katayoon; Jenabi, Ensiyeh

doi:10.2174/1573396317666210521155111

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…The study participants did not report or specify the type of used labor-inducing drugs. Recent investigations have indicated a potential correlation between the utilization of drugs during labor and delivery and the emergence of ASD 55 , 56 , especially given the increased usage of epidurals and labor-inducing medications in the past 30 years. However, conflicting findings exist, with some studies suggesting no link between the administration of labor-inducing drugs and the risk of ASD development 57 , 58 .…”

Section: Discussionmentioning

confidence: 99%

A case–control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children

Mkhitaryan,

Avetisyan,

Mkhoyan

et al. 2024

Sci Rep

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We aimed to investigate the role of pre-, peri- and neonatal risk factors in the development of autism spectrum disorder (ASD) among Armenian children with the goal of detecting and addressing modifiable risk factors to reduce ASD incidence. For this purpose a retrospective case–control study using a random proportional sample of Armenian children with ASD to assess associations between various factors and ASD was conducted. The study was approved by the local ethical committee, and parental written consent was obtained. A total of 168 children with ASD and 329 controls were included in the analysis. Multivariable logistic regression analysis revealed that male gender, maternal weight gain, use of MgB6, self-reported stress during the pregnancy, pregnancy with complications, as well as use of labor-inducing drugs were associated with a significant increase in the odds of ASD, whereas Duphaston use during pregnancy, the longer interpregnancy interval and birth height were associated with decreased odds of ASD. These findings are pertinent as many identified factors may be preventable or modifiable, underscoring the importance of timely and appropriate public health strategies aimed at disease prevention in pregnant women to reduce ASD incidence.

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Section: Discussionmentioning

confidence: 99%

A case–control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children

Mkhitaryan,

Avetisyan,

Mkhoyan

et al. 2024

Sci Rep

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“…There is evidence that preterm birth [ 32 ], small for gestational age [ 33 ], prenatal and antenatal depression [ 34 ], and labor induction [ 35 ] are risk factors for ASD, also, some studies have shown that low maternal residential greenness exposure increases the risk of mental disorders such as ASD. The neonatal risk factors such as not breast feeding [ 36 ], low weight, jaundice, congenital heart disease, low birth weight, very low birth weight, and small size for gestational age are increase risk of ASD [ 33 , 37 – 39 ].…”

Section: Discussionmentioning

confidence: 99%

The association between post-term births and autism spectrum disorders: an updated systematic review and meta-analysis

Jenabi,

Farashi,

Salehi

et al. 2023

Eur J Med Res

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Background This study aimed to conduct a meta-analysis to determine whether post-term birth has an increased risk of ASD. Materials and methods To retrieve eligible studies regarding the effect of post-term and ASD in children, major databases including PubMed, Scopus, and Web of Science were searched. A random effect model was used for meta-analysis. For assessing the quality of included studies, the GRADE checklist was used. Results In total, 18 records were included with 1,412,667 sample populations from 12 countries. The pooled estimates of RR and OR showed a significant association between post-term birth and ASD among children, respectively (RR = 1.34, 95% CI 1.10 to 1.58) and (OR = 1.47, 95% CI 1.03 to 1.91). There was no heterogeneity among the studies that reported the risk of ASD among children based on RR (I2 = 6.6%, P = 0.301). There was high heterogeneity in the studies reported risk of ASD based on OR (I2 = 94.1%, P = 0.000). Conclusion Post-term births still occur relatively frequently (up to 5–10%) even in developed countries. Our results showed that post-term birth is an increased risk of ASD, although high heterogeneity was found among the studies reported based on adjusted and crude forms, however, after subgroup analysis by gender, this heterogeneity disappeared among males.

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Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum – a systematic review with implications for the function of the oxytocinergic system

Buckley

Uvnäs‐Moberg

Pajalić

et al. 2023

BMC Pregnancy Childbirth

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Background The reproductive hormone oxytocin facilitates labour, birth and postpartum adaptations for women and newborns. Synthetic oxytocin is commonly given to induce or augment labour and to decrease postpartum bleeding. Aim To systematically review studies measuring plasma oxytocin levels in women and newborns following maternal administration of synthetic oxytocin during labour, birth and/or postpartum and to consider possible impacts on endogenous oxytocin and related systems. Methods Systematic searches of PubMed, CINAHL, PsycInfo and Scopus databases followed PRISMA guidelines, including all peer-reviewed studies in languages understood by the authors. Thirty-five publications met inclusion criteria, including 1373 women and 148 newborns. Studies varied substantially in design and methodology, so classical meta-analysis was not possible. Therefore, results were categorized, analysed and summarised in text and tables. Results Infusions of synthetic oxytocin increased maternal plasma oxytocin levels dose-dependently; doubling the infusion rate approximately doubled oxytocin levels. Infusions below 10 milliunits per minute (mU/min) did not raise maternal oxytocin above the range observed in physiological labour. At high intrapartum infusion rates (up to 32 mU/min) maternal plasma oxytocin reached 2–3 times physiological levels. Postpartum synthetic oxytocin regimens used comparatively higher doses with shorter duration compared to labour, giving greater but transient maternal oxytocin elevations. Total postpartum dose was comparable to total intrapartum dose following vaginal birth, but post-caesarean dosages were higher. Newborn oxytocin levels were higher in the umbilical artery vs. umbilical vein, and both were higher than maternal plasma levels, implying substantial fetal oxytocin production in labour. Newborn oxytocin levels were not further elevated following maternal intrapartum synthetic oxytocin, suggesting that synthetic oxytocin at clinical doses does not cross from mother to fetus. Conclusions Synthetic oxytocin infusion during labour increased maternal plasma oxytocin levels 2–3-fold at the highest doses and was not associated with neonatal plasma oxytocin elevations. Therefore, direct effects from synthetic oxytocin transfer to maternal brain or fetus are unlikely. However, infusions of synthetic oxytocin in labour change uterine contraction patterns. This may influence uterine blood flow and maternal autonomic nervous system activity, potentially harming the fetus and increasing maternal pain and stress.

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The Association between Labor Induction and Autism Spectrum Disorders Among Children: A Meta-Analysis

Cited by 3 publications

References 26 publications

A case–control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children

A case–control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children

The association between post-term births and autism spectrum disorders: an updated systematic review and meta-analysis

Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum – a systematic review with implications for the function of the oxytocinergic system

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