The association between human papillomavirus infection and female lung cancer

Lin, Frank Cheau‐Feng; Huang, Jing‐Yang; Tsai, Stella Chin‐Shaw; Nfor, Oswald Ndi; Chou, Ming‐Chih; Wu, Ming-Fang; Lee, Chun-Te; Jan, Cheng-Feng; Liaw, Yung‐Po

doi:10.1097/md.0000000000003856

Cited by 27 publications

(22 citation statements)

References 46 publications

(45 reference statements)

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“…The same HPV 16/18 DNA sequence can be detected in cervical smears, peripheral blood lymphocytes, and lung cancer [ 19 ], suggesting that HPV is likely to be transported from the cervix to the lung tissue. The lung is rich with endothelium, which can capture the virus and lead to lung cancer [ 50 ]. HPV can also be transmitted mouth to mouth or mouth to genitalia.…”

Section: Discussionmentioning

confidence: 99%

The association between human papillomavirus infection and lung cancer: a system review and meta-analysis

Xiong

et al. 2017

Oncotarget

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To estimate the global attributable fraction of human papillomavirus (HPV) in lung cancer, we provided updated information through a system review and meta-analysis. We did a literature search on PubMed, Ovid and Web of Science to identify case-control studies and cohort studies that detected HPV in lung carcinomas. We included studies that tested 30 or more cases and were published before Feb 28, 2017. We collected information about gender, smoking status, HPV detection methods, HPV types, materials and clinical features. If it was not possible to abstract the required information directly from the papers, we contacted the authors. A meta-analysis was performed to calculate the pooled effect sizes (OR/RR) with 95% confidence intervals (CI) including subgroup analysis and meta-regression to explore sources of heterogeneity, by Stata 13.0 software. 36 case-control studies, contributing data for 6,980 cases of lung cancer and 7,474 controls from 17 countries and one cohort study with 24,162 exposed and 1,026,986 unexposed from China were included. HPV infection was associated with cancer of lung, pooled OR was 3.64 (95% CI: 2.60–5.08), calculated with the random-effects model. Pooled OR for allogeneic case-control studies, self-matched case-control studies and nested case-control studies were 6.71 (95% CI: 4.07–11.07), 2.59 (95% CI: 1.43–4.69) and 0.92 (95% CI: 0.63–1.36), respectively. Pooled OR for HPV 16 and HPV 18 infection, were 3.14 (95% CI: 2.07–4.76) and 2.25 (95% CI: 1.49–3.40), respectively. We also found that HPV infection may be associated with squamous cell carcinoma, adenocarcinoma and small cell carcinoma. There is evidence that HPV infection, especially HPV 16 and HPV 18 infection, significantly increase the risk of lung cancer. Future research needs to focus attention toward whether an HPV vaccine can effectively reduce the incidence of lung cancer.

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Section: Discussionmentioning

confidence: 99%

The association between human papillomavirus infection and lung cancer: a system review and meta-analysis

Xiong

et al. 2017

Oncotarget

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“…The associations of HPV with cervical carcinoma [119], middle ear carcinoma [120], penile carcinomas [121,122], oropharyngeal cancer [123], tongue cancer [124], esophageal squamous cell carcinoma (ESCC) [125], colorectal cancer (CRC) [126,127], lung cancer [128][129][130], and breast cancer have since been demonstrated [131].…”

Section: Pathogenic Stimulus By Virusmentioning

confidence: 99%

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

Brücher

Jamall

2019

4open

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A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease. Chronic inflammation involves many cell types with numerous cytokines and signaling pathways, the release of different components by the cells, and the crosstalk provoked by such stimuli involving subclinical chronic inflammation and is mechanistically manifold. Exosomes secrete chemicals that trigger the epithelium to produce exosome-like nanoparticles promoting chronic inflammation. Small molecules, together with various cytokines, selectively target signaling pathways inducing crosstalk that suppress apoptosis. 16S rRNA gene sequencing has become routine to provide information on the composition and abundance of bacteria found in human tissues and in reservoirs. The deregulation of autophagy with chronic stimulation of inflammation is an early phenomenon in carcinogenesis. The disruption of cell–cell integrity enables transcellular CagA migration and triggers deregulation of autophagy with the net result being chronic inflammation. The complex and insidious nature of chronic inflammation can be seen both inside and outside the cell and even with intracellular nuclear fragments such as chromatin, which itself can elicit a chronic inflammatory response within the cytoplasm and affect autophagy. The ultimate result of unresolved chronic inflammation is fibrosis, a step before tissue remodeling results in the formation of a precancerous niche (PCN). Various pathogenic stimuli associated with different neoplasms result in persistent inflammation. This ongoing disruption of homeostasis in the micromilieu of cells, tissues, and organs is an essential preamble to carcinogenesis and occurs early in that process.

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“…Since Syrjanen's suggestion of HPV involvement in bronchial squamous carcinoma reported in 1979, 18,19 several studies have explored this relationship between HPV infection and lung cancer occurrence. However, the results of these studies have been inconsistent, with some authors in favor of this association [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] and the others not [37][38][39][40][41][42][43] ( Table 1). HPV infection is the most common sexually transmitted infection, with estimates for the probability of infection with the virus exceeding 80% for women and 90% for men across their lifetime.…”

Section: Hpv Hpv Detection In Lung Cancer Tissuesmentioning

confidence: 99%

<p>Possible Oncogenic Viruses Associated with Lung Cancer</p>

Ren

et al. 2020

OTT

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Lung cancer is the most common cause of cancer death worldwide. Tobacco smoking is the most predominant etiology for lung cancer. However, only a small percentage of heavy smokers develop lung cancer, which suggests that other cofactors are required for lung carcinogenesis. Viruses have been central to modern cancer research and provide profound insights into cancer causes. Nevertheless, the role of virus in lung cancer is still unclear. In this article, we reviewed the possible oncogenic viruses associated with lung cancer.

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The association between human papillomavirus infection and female lung cancer

Cited by 27 publications

References 46 publications

The association between human papillomavirus infection and lung cancer: a system review and meta-analysis

The association between human papillomavirus infection and lung cancer: a system review and meta-analysis

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

<p>Possible Oncogenic Viruses Associated with Lung Cancer</p>

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