The association between human papillomavirus infection and lung cancer: a system review and meta-analysis

Abstract

To estimate the global attributable fraction of human papillomavirus (HPV) in lung cancer, we provided updated information through a system review and meta-analysis. We did a literature search on PubMed, Ovid and Web of Science to identify case-control studies and cohort studies that detected HPV in lung carcinomas. We included studies that tested 30 or more cases and were published before Feb 28, 2017. We collected information about gender, smoking status, HPV detection methods, HPV types, materials and clinical features. If it was not possible to abstract the required information directly from the papers, we contacted the authors. A meta-analysis was performed to calculate the pooled effect sizes (OR/RR) with 95% confidence intervals (CI) including subgroup analysis and meta-regression to explore sources of heterogeneity, by Stata 13.0 software. 36 case-control studies, contributing data for 6,980 cases of lung cancer and 7,474 controls from 17 countries and one cohort study with 24,162 exposed and 1,026,986 unexposed from China were included. HPV infection was associated with cancer of lung, pooled OR was 3.64 (95% CI: 2.60–5.08), calculated with the random-effects model. Pooled OR for allogeneic case-control studies, self-matched case-control studies and nested case-control studies were 6.71 (95% CI: 4.07–11.07), 2.59 (95% CI: 1.43–4.69) and 0.92 (95% CI: 0.63–1.36), respectively. Pooled OR for HPV 16 and HPV 18 infection, were 3.14 (95% CI: 2.07–4.76) and 2.25 (95% CI: 1.49–3.40), respectively. We also found that HPV infection may be associated with squamous cell carcinoma, adenocarcinoma and small cell carcinoma. There is evidence that HPV infection, especially HPV 16 and HPV 18 infection, significantly increase the risk of lung cancer. Future research needs to focus attention toward whether an HPV vaccine can effectively reduce the incidence of lung cancer.

Human papillomavirus infection maybe not associated with primary lung cancer in the Fujian population of China

“…Therefore, HPV infection is likely to be closely related to the occurrence and development of primary lung cancer. Our previous meta‐analysis also suggested that the positive detection rate of HPV infection in lung cancer tissues was 2.59 times that in paracancerous tissues . Galvan et al .…”

“…Our previous meta-analysis also suggested that the positive detection rate of HPV infection in lung cancer tissues was 2.59 times that in paracancerous tissues. 17 Galvan et al 18 who used the same detection methods to identify HPV DNA in 100 pairs of lung cancer tissues and matched adjacent normal tissues, found that all the tumor samples were free of HPV infection, and deemed that HPV infection was not associated with the risk of lung cancer in a European population. Other studies have reported that the positive detection rate of HPV infection in lung cancer tissues in Asian populations (28.1%-35.7%) is generally higher than in European (8.4%-17%) and American (15%-21.3%) populations.…”

The absence of high-risk human papillomavirus in Czech non-small cell lung cancer cases

“…Chinese studies, for example, show HPV prevalence in China ranging from 8.4% to 73% (ref. [22][23][24]. High rates of false positives could be contributing to the large variability in HPV prevalence.…”

“…These facts led to the hypothesis that here is an association between HPV infection and lung cancer. Several studies have examined the impact of the HPV infection on lung cancer development, including large meta-analyses, but with conflicting results [9][10][11][12][13] .…”

The Association between Human Papillomavirus Infection and Smoking, Age, Gender in Lung Cancer Patients: A Meta-Analysis

“…After screening the title and abstract of the 1391 unique references, 1339 were excluded, and 52 studies were required for further assessment. After screening full-text reviews, 33 studies excluded, while only 19 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) articles fulfilled the predefined inclusion criteria and were selected to be involved in the analysis, eligible studies in this meta-analysis.…”