The association between human leukocyte antigen (HLA)-G polymorphisms and human papillomavirus (HPV) infection in Inuit women of northern Quebec

Metcalfe, Stephanie; Roger, Michel; Faucher, Marie-Claude; Coutlée, François; Franco, Eduardo L.; Brassard, Paul

doi:10.1016/j.humimm.2013.08.279

Cited by 32 publications

(30 citation statements)

References 30 publications

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“…HLA-G is a nonclassical HLA class Ib molecule that regulates the immune response through interaction with surface receptors on natural killer, T and antigen-presenting cells [37]–[40]. Several studies have reported associations between HLA-G polymorphisms and HPV infection susceptibility and persistence [39]–[41]. A 14 base pair deletion in the 3′ of HLA has also been shown to promote high-risk HPV infection and invasive cervical cancer in various populations [42]–[44].…”

Section: Discussionmentioning

confidence: 99%

Dense Genotyping of Immune-Related Loci Identifies Variants Associated with Clearance of HPV among HIV-Positive Women in the HIV Epidemiology Research Study (HERS)

et al. 2014

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Persistent high-risk human papillomavirus (HR-HPV) is a necessary and causal factor of cervical cancer. Most women naturally clear HPV infections; however, the biological mechanisms related to HPV pathogenesis have not been clearly elucidated. Host genetic factors that specifically regulate immune response could play an important role. All HIV-positive women in the HIV Epidemiology Research Study (HERS) with a HR-HPV infection and at least one follow-up biannual visit were included in the study. Cervicovaginal lavage samples were tested for HPV using type-specific HPV hybridization assays. Type-specific HPV clearance was defined as two consecutive HPV-negative tests after a positive test. DNA from participants was genotyped for 196,524 variants within 186 known immune related loci using the custom ImmunoChip microarray. To assess the influence of each single-nucleotide polymorphism (SNP) with HR-HPV clearance, the Cox proportional hazards model with the Wei-Lin-Weissfeld approach was used, adjusting for CD4+ count, low risk HPV (LR-HPV) co-infection, and relevant confounders. Three analytical models were performed: race-specific (African Americans (n = 258), European Americans (n = 87), Hispanics (n = 55), race-adjusted combined analysis, and meta-analysis of pooled independent race-specific analyses. Women were followed for a median time of 1,617 days. Overall, three SNPs (rs1112085, rs11102637, and rs12030900) in the MAGI-3 gene and one SNP (rs8031627) in the SMAD3 gene were associated with HR-HPV clearance (p<10−6). A variant (rs1633038) in HLA-G were also significantly associated in African American. Results from this study support associations of immune-related genes, having potential biological mechanism, with differential cervical HR-HPV infection outcomes.

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Section: Discussionmentioning

confidence: 99%

Dense Genotyping of Immune-Related Loci Identifies Variants Associated with Clearance of HPV among HIV-Positive Women in the HIV Epidemiology Research Study (HERS)

et al. 2014

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“…Immunologic differences between these ethnic groups (HLA allele frequencies in Amerindians versus Maroons for example [23]) could also influence the observed patterns of HPV genotypes. [24–27] Further studies should however test this hypothesis. As observed elsewhere [14], there was a U-shaped evolution of HPV prevalence with women over 50 years of age having the highest HPV prevalence, and also being more likely to be infected by more than one HPV genotype.…”

Section: Discussionmentioning

confidence: 99%

The singular epidemiology of HPV infection among French Guianese women with normal cytology

et al. 2017

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BackgroundIn French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.MethodsBefore the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.ResultsOverall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.ConclusionsHPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.

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“…A study analyzed the associations between HLA-G polymorphisms and HPV infection and squamous intraepithelial lesions (SIL) in Inuit women from Nunavik, northern Quebec. The group demonstrated that HLA-G * 01:01:01 was associated with an increased risk of period prevalent alpha groups 1 and 3 [164]. The HLA-G * 01:04:01 genotype was associated with a decreased risk of alpha group 3 infection period prevalence.…”

Section: Hla and Papillomavirus Infectionmentioning

confidence: 98%

HLA and Infectious Diseases

Cardozo¹,

Marangon²,

Sell³

et al. 2014

HLA and Associated Important Diseases

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HLA and Associated Important Diseases 260CD . During antigen presentation, CD and CD are intimately associated with the TCR and bind to the MHC molecule [ ].. Haplotype, linkage disequilibrium and HLA genes expression HL" genes are transmitted for Mendel segregation and allelic variant is expressed in a codominant mode. The set of HL" alleles present in each chromosome of the pair is denominated haplotype. The probability of a sibling having the same HL" haplotype as the other is %, different haplotypes is % and % are share only one haplotype [ ].Moreover, there is a fact that occurs in HL" genes called linkage disequilibrium which denotes that certain alleles occur together with a greater frequency than would be expected by chance non-random gametic association . Variations in the expected combinations of alleles in the population, more often or less often than would be expected from a random formation of haplotypes from alleles, could be related to linkage disequilibrium [ ]. For example, a determined population has a gene frequency of % for HLA-A* and % for HLA-B* , therefore the expected frequency for this haplotype would be . % . x . , the actual frequency is however, . % in this population, a higher frequency than expected, characterizing a positive linkage disequilibrium [ ].. HLA and infection diseasesThe frequency and the presence of HL" alleles vary among different populations. Studies suggest that the alleles that can confer resistance to certain pathogens are prevalent in areas with endemic diseases. Furthermore, genomic analysis in families has helped to map and identify the loci related to a number of diseases. Moreover, a number of diseases have been mapped and had their related loci identified thanks to the genomic analysis of families.

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The association between human leukocyte antigen (HLA)-G polymorphisms and human papillomavirus (HPV) infection in Inuit women of northern Quebec

Cited by 32 publications

References 30 publications

Dense Genotyping of Immune-Related Loci Identifies Variants Associated with Clearance of HPV among HIV-Positive Women in the HIV Epidemiology Research Study (HERS)

Dense Genotyping of Immune-Related Loci Identifies Variants Associated with Clearance of HPV among HIV-Positive Women in the HIV Epidemiology Research Study (HERS)

The singular epidemiology of HPV infection among French Guianese women with normal cytology

HLA and Infectious Diseases

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