The singular epidemiology of HPV infection among French Guianese women with normal cytology

Adenis, Antoine; Dufit, Valentin; Douine, Maylis; Najioullah, Fatiha; Molinié, Vincent; Catherine, Dominique; Kilié, Odile; Thomas, Nadia; Deshayes, Jean; Brousse, Paul; Amor, Hatem Ben; Pignoux, Remy; Carles, Gabriel; Grenier, Claire; Lacoste, Vincent; Césaire, Raymond

doi:10.1186/s12889-017-4181-3

Cited by 13 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The estimated rate of HPV infection was also higher than that reported in HIV-negative women living in the same area. A study conducted in the French Caribbean island of Guadeloupe showed a prevalence of HR-HPV of 36% among healthy women [29], and two recent studies reported that HPV prevalence in French Guiana reached 35% in women with normal cytology [30,31]. Based on this indirect comparison between HIV-positive and HIV-negative women, and despite the fact that the expected high rate of HPV infection in the French Caribbean population [29] could have minimized the impact of the co-infection, the present study strengthens the concept of an association between HIV and HPV infections.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana

et al. 2019

Self Cite

View full text Add to dashboard Cite

An association between HIV infection and cervical cancer, a major public health issue worldwide, has been reported. The aim of this study was to estimate the prevalence of human papillomavirus (HPV) infection and the distribution of HPV genotypes in HIV-infected women living in French Antilles and Guiana and to determine HIV-related characteristics associated with HPV infection. This cross-sectional study included 439 HIV-infected women who were followed between January 2011 and May 2014. Variables related to HIV infections were collected, and cervical samples were analysed to determine HPV genotypes. The median age of the population was 46 years. Estimated prevalence of HPV and high-risk (HR)-HPV infection were 50.1% IC95 [45.4–54.7] and 42% IC95 [37.3–46.6], respectively. HR-HPV 16, 52, 53 or intermediate risk-HPV-68 were found in 25% to 30% of the HPV-infected patients. Gynaecological screening revealed abnormal cervical smear in 24% and 42% of HR-HPV-negative and HPV-positive women, respectively (p = 0.003). Approximately 90% of women were on antiretroviral therapy (ART). Demographic characteristics associated with a higher prevalence of HPV infection included alcohol consumption. Regarding HIV-related characteristics, current therapy on ART, its duration, and undetectable plasma concentrations of RNA-HIV1 were associated with a lower risk of HPV infection. Infection rate with HR-HPV was higher than what is commonly reported in HIV-negative women worldwide and was more likely in women with incomplete HIV suppression. These results highlight the need for supporting adherence to ART, cervical cytology, HPV testing and HPV vaccination.

show abstract

Section: Discussionmentioning

confidence: 99%

High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…The main HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). This study also reported a prevalence of HPV 16 of 6.8% among HPV-infected women [ 36 ].…”

Section: Discussionmentioning

confidence: 70%

Gynaecological cancer in Caribbean women: data from the French population-based cancer registries of Martinique, Guadeloupe and French Guiana (2007–2014)

et al. 2020

View full text Add to dashboard Cite

Background For the first time, we present regional-level cancer incidence and world-standardized mortality rates for cancers for Martinique, Guadeloupe and French Guiana. Methods For Martinique, Guadeloupe and French Guiana, incidence data come from population-based cancer registries, and cover the periods 2007–2014, 2008–2014 and 2010–2014 respectively. Standardized incidence and mortality rates were calculated using the world population. Results In the 3 regions, all cancers combined represent 3567 new cases per year, of which 39.8% occur in women, and 1517 deaths per year (43.4% in women). Guadeloupe and Martinique present similar world-standardized incidence rates. Among gynaecological cancers, breast cancer, the second most common cancer type in the 3 regions, has an incidence rate 35 to 46% lower than in mainland France. On the other hand, cervical cancer has a higher incidence rate, particularly in French Guiana. For both endometrial cancer and ovarian cancer, no significant differences in incidence rates are found compared to mainland France. Regarding mortality, world-standardized mortality rates are similar between Guadeloupe and Martinique, and higher than in French Guiana. This situation compares favourably with mainland France (all cancers). Among gynaecological cancers, the mortality rate is lower for breast cancer in all regions compared to mainland France, and also lower for ovarian cancer in Martinique and Guadeloupe, but higher (albeit non-significantly) in French Guiana. Conclusion The ethno-geographic and socio-demographic characteristics in this population of mainly Afro-Caribbean origin could partially explain these disparities. Major disparities exist for certain cancer sites: excess incidence and excess mortality for cervical cancer; lower, but increasing incidence of breast cancer.

show abstract

“…Information on HPV genotypes in cancer samples is not yet available in French Guiana. However, we have shown that among women living on the Maroni and Oyapock rivers, the prevalence of HPV was particularly high and that the genotypes found by performing HPV testing were quite different and justified the use of nonavalent vaccines to prevent cervical cancer in these remote areas of high prevalence [ 3 , 6 , 7 ]. Moreover, the proportion of abnormal smears was higher than what is observed in mainland France.…”

Section: Introductionmentioning

confidence: 99%

“…Between 2012 and 2014, an HPV prevalence study was conducted in women aged 20–65 years living in these remote parts of French Guiana. HPV16, 18, 31, 52, 58, and 68 were the most frequent high-risk genotypes among these women [ 3 , 6 ]. The objective of the present study was to describe the phylogeny of E6 and E7 sequences of the most common high-risk HPV genotypes in these regions.…”

Section: Introductionmentioning

confidence: 99%

E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana

Godefroy

Dufit²,

Douine³

et al. 2020

Microorganisms

Self Cite

View full text Add to dashboard Cite

Amerindian and Maroon populations of French Guiana have been living in isolation for generations and sexual networks remained mostly endogamous. The present study aimed to describe the phylogeny of E6 and E7 sequences of the most common high-risk HPV genotypes in these regions, to ascertain the diversity of intra-type variants and describe evolutionary relationships. There were 106 women with at least one of HPV16, 18, 31, 52, 58, and 68 genotypes. The most clear-cut phylogenetic pattern was obtained for HPV18 and HPV58 for which the major branches were crisply divided between Amerindian villages on the Oyapock and Maroon villages on the Maroni. Such clustering was less clear for HPV31 and 52. For HPV16, there was also some evidence of clustering on the Oyapock with type A European viruses and on the Maroni with type B and C African viruses among Maroon women. HPV68 showed the largest sequence heterogeneity of the six genotypes at both nucleotide and amino acid levels and was restricted to Maroon women. The present results show that there were significant geographically based differences of E6 and E7 oncogenes. These differences were compatible with different ancestral virus populations and local virus evolution in a context of prolonged population isolation.

show abstract

The singular epidemiology of HPV infection among French Guianese women with normal cytology

Cited by 13 publications

References 23 publications

High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana

High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana

Gynaecological cancer in Caribbean women: data from the French population-based cancer registries of Martinique, Guadeloupe and French Guiana (2007–2014)

E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana

Contact Info

Product

Resources

About