The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Abstract

Aims/hypothesis Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evaluate the association between H. pylori infection and risk of developing diabetes. Methods We performed a population-based prospective study, recruiting participants aged 45-74 years and without diabetes from the Chinese Multi-provincial Cohort Study in 2002, with a 10 year follow-up to investigate development of diabetes. H. pylori serostatus was determined by measuring serum H. pylori antibodies. H. pylori seropositivity was defined as the antibody concentration ≥ 10 U/ml. To examine the association between H. pylori seropositivity and diabetes risk, modified Poisson regression was performed. Results Of 2085 participants without diabetes, 1208 (57.9%) were H. pylori seropositive in 2002. After multivariate adjustment of possible diabetes risk factors, H. pylori seropositivity was associated with lower risk of diabetes (RR 0.78 [95% CI 0.63, 0.97], p = 0.022). Of the 1275 participants with H. pylori antibody measurements in both 2002 and 2007, 677 (53.1%) were persistently seropositive. A lower risk of diabetes was also observed in participants with persistent H. pylori seropositivity (RR 0.61 [95% CI 0.41, 0.93], p = 0.020), compared with those persistently seronegative. Conclusions/interpretation H. pylori seropositivity was associated with lower risk of diabetes in this prospective cohort study. Extrapolation of these results and the mechanism underlying the observed association require further investigation.

Association between Helicobacter pylori infection, eradication and diabetes mellitus

“…So far, although a number of studies have examined an association between H. pylori infection and diabetes, the results were conflicting. Part of the reason for the conflicting results could be due to small sample size and inappropriate adjustment of risk factors.…”

“…Although a number of studies have examined the association between H. pylori and diabetes, the results were conflicting. Furthermore, if there is a link between H. pylori infection and diabetes, it is natural to expect a change in diabetes state after eradication.…”

Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study

“…Kayar et al showed a significant relationship between HP infection and MetS, insulin resistance, inflammation, and diabetic complications[9]. Recently, seropositivity of HP infection was reported to be associated with lower risk of DM[16]. However, the concentrations of antibodies against CagA, a major factor in HP infection, might be elevated in patients who had a negative HP serological test[11].…”

Течение Пептических Гастродуоденальных Язв На фоне Коморбидного Сахарного Диабета

“…Частота Нр при наличии коморбидного СД выше, чем при ЯЖ и ЯК без такой эндокринной патологии [17,18]. Серопозитивность больных СД по Нр составляет около 60 % [19], а носительство инфекции регистрируется на 90 % чаще, чем в общей популяции, что прямо коррелирует с уровнями в крови фактора некроза опухоли α, маннозосвязанного лектина и липопротеинов низкой плотности. С хеликобактерной инфекцией у таких больных тесно связаны генотипы rs1800450 AA и rs1800620 [20].…”