2023
DOI: 10.1038/s41398-023-02450-1
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The association between gut microbiota and postoperative delirium in patients

Abstract: Postoperative delirium is a common postoperative complication in older patients, and its pathogenesis and biomarkers remain largely undetermined. The gut microbiota has been shown to regulate brain function, and therefore, it is vital to explore the association between gut microbiota and postoperative delirium. Of 220 patients (65 years old or older) who had a knee replacement, hip replacement, or laminectomy under general or spinal anesthesia, 86 participants were included in the data analysis. The incidence … Show more

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Cited by 8 publications
(5 citation statements)
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“…Alterations in the gut microbiome have been a topic of research for multiple diseases due to its effects on the brain and a possible role in neuroinflammation 14 . The abundance of specific gut bacteria, such as Escherichia shigella in the preoperative period 38 and Parabacteroides distasonis in the postoperative period, were shown to be different in those patients that developed POD 39 and could be used as possible biomarkers for future research and study 39 . In addition, targeting the gut microbiota with administration of lactobacillus and probiotics successfully reverted delirium-like behavior on mice 40 .…”
Section: Current Evidencementioning
confidence: 99%
“…Alterations in the gut microbiome have been a topic of research for multiple diseases due to its effects on the brain and a possible role in neuroinflammation 14 . The abundance of specific gut bacteria, such as Escherichia shigella in the preoperative period 38 and Parabacteroides distasonis in the postoperative period, were shown to be different in those patients that developed POD 39 and could be used as possible biomarkers for future research and study 39 . In addition, targeting the gut microbiota with administration of lactobacillus and probiotics successfully reverted delirium-like behavior on mice 40 .…”
Section: Current Evidencementioning
confidence: 99%
“…The gut microbiota also has emerged as a key regulator of host pathophysiology. Its involvement has been linked to the development of numerous disorders, such as cancer, celiac disease, various neurological conditions, inflammatory bowel disease, and major depressive disorder [111][112][113][114][115][116]. Furthermore, the immune system can be modulated by the microbiome, which might lead to the pathophysiology of autoimmune disorders [117][118][119][120].…”
Section: Insights Into the Complexities Of The Human Microbiotamentioning
confidence: 99%
“…In a prospective clinical study, it was concluded by analyzing the gut microbiota of elderly patients after surgery, in which Parabacteroides distasonis was associated with POD. However, Prevotella and Colinella were not statistically associated with the occurrence of POD [ 50 ]. This appears to imply that alterations of gut microbiota diversity are influenced by factors such as age, species, and mode of intervention.…”
Section: Mechanisms Of Exercise Interventions For Pod and Pocdmentioning
confidence: 99%