The association between early pregnancy exposure to green space and maternal glucolipid metabolism disorders: evaluation of the mediating role of serum 25-hydroxyvitamin D

Yu, Weijie; Li, Ying-Qing; Zhang, Kang-Di; Wang, Xinqiang; Wang, Jie; Cheng, Xin; Li, Zhenhua; Mao, Yi-Cheng; Zhao, Jia-Wen; Li, Tao; Chen, Maolin; Gao, Guopeng; Di, Kun; Hu, Chengyang; Zhang, Xiujun

doi:10.1007/s11356-022-25073-3

Cited by 1 publication

(2 citation statements)

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“…While there exists a limited body of research revealing the biological mechanisms linking exposure to greenness, existing studies have posited DNA methylation (Xu et al 2021a, 2021b, Jeong et al 2022, blood glucose levels (Liao et al 2019) and glycolipid metabolism (Yu et al 2023) as potential biological mechanisms. For instance, a study involving 479 Australian women found that exposure to greenness was associated with signs of slower biological aging (Xu et al 2021b).…”

Section: Discussionmentioning

confidence: 99%

“…Another study focused on maternal exposure to greenness during pregnancy and discovered a correlation with cord blood DNA methylation (Alfano et al 2023). Moreover, there's evidence suggesting that exposure to green spaces might enhance glucolipid metabolism, potentially through an increase in vitamin D levels (Yu et al 2023). Notably, a prospective birth cohort study highlighted that maternal glucose levels, taken between 24 and 28 weeks of gestation, had an inverse relationship with residential greenness exposure (Liao et al 2019).…”

Section: Discussionmentioning

confidence: 99%

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Critical windows of greenness exposure during preconception and gestational periods in association with birthweight outcomes

Yang,

Liao,

Zhang

et al. 2023

Environ. Res.: Health

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Few studies have examined the association between greenness exposure and birth outcomes. This study aims to identify critical exposure time windows during preconception and pregnancy for the association between greenness exposure and birth weight. A cohort of 13 890 pregnant women and newborns in Shanghai, China from 2016–2019 were included in the study. We assessed greenness exposure using Normalized Difference Vegetation Index (NDVI) during the preconception and gestational periods, and evaluated the association with term birthweight, birthweight z-score, small-for-gestational age, and large-for-gestational age using linear and logistic regressions adjusting for key maternal and newborn covariates. Ambient temperature, relative humidity, ambient levels of fine particles (PM2.5) and nitrogen dioxide (NO2) assessed during the same period were adjusted for as sensitivity analyses. Furthermore, we explored the potential different effects by urbanicity and park accessibility through stratified analysis. We found that higher greenness exposure at the second trimester of pregnancy and averaged exposure during the entire pregnancy were associated with higher birthweight and birthweight Z-score. Specifically, a 0.1 unit increase in second trimester averaged NDVI value was associated with an increase in birthweight of 10.2 g (95% CI: 1.8–18.5 g) and in birthweight Z-score of 0.024 (0.003–0.045). A 0.1 unit increase in an averaged NDVI during the entire pregnancy was associated with 10.1 g (95% CI: 1.0–19.2 g) increase in birthweight and 0.025 (0.001–0.048) increase in birthweight Z-score. Moreover, the associations were larger in effect size among urban residents than suburban residents and among residents without park accessibility within 500 m compared to those with park accessibility within 500 m. Our findings suggest that increased greenness exposure, particularly during the second trimester, may be beneficial to birth weight in a metropolitan area.

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