The association between dietary total antioxidant capacity with risk of rheumatoid arthritis in adults: A case–control study

Moradi, Arezoo; Nezamoleslami, Shokufeh; Nezamoleslami, Saeed; Clark, Cain C. T.; Sohouli, Mohammad Hassan; Ghiasvand, Reza

doi:10.1016/j.clnesp.2022.07.013

Cited by 8 publications

(6 citation statements)

References 54 publications

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“…CDAI is another new method used to evaluate oxidative stress and inflammation status of certain diseases. Previous studies showed that dietary total antioxidant capacity (DTAC) is negatively associated with oxidative stress of hyperuricemia, rheumatoid arthritis, hypertension, and CKD (Choi et al, 2009; Cyuńczyk et al, 2022; Moradi et al, 2022; Yang et al, 2022). These results are consistent with our findings that DTAC is associated with oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Composite Dietary Antioxidant Index and Gout: National Health and Nutrition Examination Survey 2007–2018

Hu,

Ye,

et al. 2023

Biological Research For Nursing

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Introduction: To explore the relationship between the composite dietary antioxidant index (CDAI) and gout to provide support for preventing gout through dietary intervention. Methods: Eligible participants from the 2007 to 2018 National Health and Nutrition Examination Survey aged 20 years and older were included in this cross-sectional study. The weighted chi-square test was used to compare the categorical variables difference between CDAI quartiles groups. The weighted univariate and binary logistic regression analysis were used to test the association between variables and gout. The weighted multivariable logistic regression was used to test the association of CDAI and gout in 4 different models. Subgroup analysis on the associations of CDAI with gout was conducted with stratified factors. Results: The final participants were 26,117, 13,103 (50.17%) were female, 8718 (33.38%) were 40–59 years, 11,200 (42.88%) were white and 1232 (4.72%) had gout. After adjusting for all covariates, the CDAI was associated with gout (odds ratio (OR), .97; 95% CI: .95–1.00). Participants in the highest CDAI quantile group were at low risk of gout (odds ratio (OR), .65; 95% CI: .50–.84) versus those in the lowest quantile group. Subgroup analysis and interaction test showed no significant dependence on diabetes mellitus (DM), marital status, alcohol status, hypertension, poverty income ratio (PIR), education level, body mass index (BMI), smoke status, age, sex, race, and chronic kidney disease (CKD) on this association (all p for interaction >.05). Conclusions: Composite dietary antioxidant index was inversely associated with gout in US adults, and dietary antioxidant intervention might be a promising method in the therapy of gout and greater emphasis should be placed on zinc, selenium, carotenoids, vitamins A, C, and E.

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Section: Discussionmentioning

confidence: 99%

Associations Between Composite Dietary Antioxidant Index and Gout: National Health and Nutrition Examination Survey 2007–2018

Hu,

Ye,

et al. 2023

Biological Research For Nursing

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“…The data in table (2) demonstrated that, when compared to a normal control group, CFA-induced arthritis rats had highly significant serum levels of urea, creatinine, FBS concentration, ALT, and AST activities.…”

Section: Determination Of the Biochemical Parametersmentioning

confidence: 99%

Biochemical, Molecular and Histopathological changes of rheumatoid arthritis induced experimentally in rats

Amer

Elhamid

Ali

et al. 2023

Benha Veterinary Medical Journal

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Complete Freund's adjuvant (CFA) is a mixture of desiccated mycobacterium in mannide monooleate and paraffin oil that causes tissue death, lesions, and inflammation. Immunologists have been inducing inflammatory conditions and autoimmune diseases in laboratory animals using CFA for more than 50 years. Rheumatoid arthritis (RA) is a disease marked by ongoing inflammation that affects more than just joints. Twenty male rats were divided into two groups (10 each), Normal control group: Rats were given no medication. CFA-induced arthritis group: Rats were injected with Complete Freund's adjuvant (0.1 ml, once). After 60 days blood samples and Stifle joints were collected for biochemical assay and genetic study of some signaling transducers including IFNγ, Interleukin-4, STAT3 and Interleukin-12. The results revealed that CFA induced rheumatoid arthritis in rats causing an increase in serum liver enzymes and serum concentration of creatinine, urea, FBS, RF, Anti-CCP and CRP, while decreasing in serum total antioxidant capacity (TAC) concentration. Moreover, there was up regulation of IL-12, IFNγ and STAT3 gene, and down regulation of IL-4 gene in CFA-induced arthritis group contrasted with the control group. On conclusion, CFA injection into leg footpad of rats induced arthritic animal model associated with similar inflammatory changes recorded in RA patients IFNγ IL-12 IL-4 Rheumatoid arthritis STAT3

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“…On the other hand, findings from more recent studies suggest that synthetic antioxidants should be regulated because of the possible risks to human health, including liver damage and carcinogenesis [ 144 , 145 ]. Therefore, it is absolutely necessary to discover and make use of powerful naturally occurring antioxidants in order to shield the human body from the damage caused by free radicals and to lower the risk of an extensive range of diseases, including cancer, arthritis, and cardiac disorders [ 146 , 147 ].…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites

Ahmad,

A. Alsayegh,

Ahmad

et al. 2024

Heliyon

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The association between dietary total antioxidant capacity with risk of rheumatoid arthritis in adults: A case–control study

Cited by 8 publications

References 54 publications

Associations Between Composite Dietary Antioxidant Index and Gout: National Health and Nutrition Examination Survey 2007–2018

Associations Between Composite Dietary Antioxidant Index and Gout: National Health and Nutrition Examination Survey 2007–2018

Biochemical, Molecular and Histopathological changes of rheumatoid arthritis induced experimentally in rats

Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites

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