The Association Between Detectable Plasmatic Human Immunodeficiency Virus (HIV) Viral Load and Different Subgingival Microorganisms in Brazilian Adults With HIV: A Multilevel Analysis

Pereira, Viviane Tiago; Pavan, Priscila; Souza, Rodrigo Carvalho de; Souto, Renata; Vettore, Mário Vianna; Torres, Sandra Regina; Colombo, Ana Paula Vieira; Uzeda, Milton de; Sansone, Carmelo; Gonçalves, Lúcio Souza

doi:10.1902/jop.2013.130273

Cited by 25 publications

(26 citation statements)

References 48 publications

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“…Oral lesions are often the first manifestation of HIV in places where the access to regular health care or ART is limited. Periodontal pathogens are more prevalent in HIV-infected individuals 50 . Oral microbial diversity with increased levels of total Lactobacillus species and Candida species was found to be greater in HIV-infected patients than uninfected controls 41 .…”

Section: Oral and Periodontal Microbiomementioning

confidence: 99%

Microbiome in Human Immunodeficiency Virus Infection

Salas

Chang

2014

Clinics in Laboratory Medicine

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HIV primary infection occurs at mucosa tissues, suggesting an intricate interplay between microbiome and HIV infection. Recent advanced technologies of high-throughput sequencing and bioinformatics allow researchers to explore nonculturable microbes including bacteria, virus and fungi and their association with diseases. HIV/SIV infection is associated with microbiome shifts and immune activation that may affect the outcome of disease progression. Similarly, altered microbiome and inflammation are associated with increased risks of HIV acquisition, suggesting the role of microbiome in HIV transmission. In this review, we will focus on microbiome in HIV infection at various mucosal compartments. Understanding the relationship between microbiome and HIV may offer insights into development of better strategies for HIV prevention and treatment.

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Section: Oral and Periodontal Microbiomementioning

confidence: 99%

Microbiome in Human Immunodeficiency Virus Infection

Salas

Chang

2014

Clinics in Laboratory Medicine

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“…gingivitis, stomatitis, periodontitis) and extra-oral (e.g. infective endocarditis) disease, and alterations of the oral microbiota have been identified in individuals with HIV infection [2,12-14]. …”

Section: Introductionmentioning

confidence: 99%

The oral and conjunctival microbiotas in cats with and without feline immunodeficiency virus infection

Weese

Nichols

Jalali

et al. 2015

Vet Res

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The oral and conjunctival microbiotas likely play important roles in protection from opportunistic infections, while also being the source of potential pathogens. Yet, there has been limited investigation in cats, and the impact of comorbidities such as feline immunodeficiency virus (FIV) infection has not been reported. Oral and conjunctival swabs were collected from cats with FIV infection and FIV-uninfected controls, and subjected to 16S rRNA gene (V4) PCR and next generation sequencing. 9,249 OTUs were identified from conjunctival swabs, yet the most common 20 (0.22%) OTUs accounted for 76% of sequences. The two most abundant OTUs both belonged to Staphylococcus, and accounted for 37% of sequences. Cats with FIV infection had significantly lower relative abundances of Verrucomicrobia, Fibrobacteres, Spirochaetes, Bacteroidetes and Tenericutes, and a higher relative abundance of Deinococcus-Thermus. There were significant differences in both community membership (P = 0.006) and community structure (P = 0.02) between FIV-infected and FIV-uninfected cats. FIV-infected cats had significantly higher relative abundances of Fusobacteria and Actinobacteria in the oral cavity, and significantly higher relative abundances of several bacterial classes including Fusobacteria (0.022 vs 0.007, P = 0.006), Actinobacteria (0.017 vs 0.003, P = 0.003), Sphingobacteria (0.00015 vs 0.00003, P = 0.0013) and Flavobacteria (0.0073 vs 0.0034, P = 0.030). The feline conjunctival and oral microbiotas are complex polymicrobial communities but dominated by a limited number of genera. There is an apparent impact of FIV infection on various components of the microbiota, and assessment of the clinical relevance of these alterations in required.

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“…The periodontal microbiota is composed of a highly complex bacterial multispecies community organized in biofilms . Several studies have investigated the composition of the periodontal microbiota in HIV‐infected individuals . Interestingly, a higher prevalence of periodontal pathogens has been demonstrated in non‐HIV‐infected than in HIV‐infected individuals .…”

mentioning

confidence: 99%

“…Interestingly, a higher prevalence of periodontal pathogens has been demonstrated in non‐HIV‐infected than in HIV‐infected individuals . However, microorganisms not commonly associated with periodontitis have frequently been detected in subgingival sites of HIV‐infected patients, including Staphylococcus epidermidis , Candida albicans, Enterococcus faecalis , Clostridium difficile , Mycoplasma salivarium , Klebsiella pneumoniae , Pseudomonas aeruginosa , Acinetobacter baumannii and Entamoeba gingivalis . In particular , E. faecalis was more prevalent in the subgingival microbiota of HIV‐infected patients with reduced levels of TCD4 + lymphocytes (< 200 cells/mm 3 ), suggesting that HIV‐related immunodeficiency can provide appropriate conditions for the colonization and growth of opportunistic pathogens in the oral microbiota .…”

mentioning

confidence: 99%

Subgingival bacterial community profiles in HIV‐infected Brazilian adults with chronic periodontitis

Ferreira

Gonçalves

Siqueira

et al. 2015

J of Periodontal Research

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The Association Between Detectable Plasmatic Human Immunodeficiency Virus (HIV) Viral Load and Different Subgingival Microorganisms in Brazilian Adults With HIV: A Multilevel Analysis

Abstract: Detectable plasmatic HVL in individuals with HIV was associated with elevated levels of known periodontal pathogens, such as P. nigrescens, T. forsythia, and E. corrodens, as well as C. concisus, C. gingivalis, and D. pneumosintes in the subgingival biofilm.

Cited by 25 publications

References 48 publications

Microbiome in Human Immunodeficiency Virus Infection

Microbiome in Human Immunodeficiency Virus Infection

The oral and conjunctival microbiotas in cats with and without feline immunodeficiency virus infection

Subgingival bacterial community profiles in HIV‐infected Brazilian adults with chronic periodontitis

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