The association between  COMT  rs4680 and  OPRM1  rs1799971 polymorphisms and temperamental traits in combat athletes

Leźnicka, Katarzyna; Niewczas, Marta; Kurzawski, Mateusz; Safranow, Krzysztof; Ligocka, Maria; Białecka, Monika

doi:10.1016/j.paid.2017.12.008

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…The association between genetic variation and temperamental traits has been also confirmed in a study conducted by Leznicka and co-workers, in which associations between a functional polymorphism of the COMT gene and FCB-TI scores for temperament traits were found [24]. In this group of combat athletes, homozygous subjects with the Val allele (Val/Val) were characterised by lower sensitivity compared with the Met allele carriers (Met/Met or Met/Val) [24].…”

Section: Discussionsupporting

confidence: 55%

“…In the other study, the authors suggested that the chronic levels of physical activity, as seen in ultra-endurance athletes, show increased novelty-seeking in Met (158) homozygous allele carriers supporting the hypothesis that there is an association between personality traits and COMT Val158Met (rs4680) genotype [23]. The association between genetic variation and temperamental traits has been also confirmed in a study conducted by Leznicka and co-workers, in which associations between a functional polymorphism of the COMT gene and FCB-TI scores for temperament traits were found [24]. In this group of combat athletes, homozygous subjects with the Val allele (Val/Val) were characterised by lower sensitivity compared with the Met allele carriers (Met/Met or Met/Val) [24].…”

Section: Discussionsupporting

confidence: 53%

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Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Żmijewski

Leońska-Duniec

Stuła

et al. 2021

Genes

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Swimmers’ competitive performance is a result of complicated interactions between physiological, biochemical, physical and psychological factors, all of which are strongly affected by water. Recently, great attention has been paid to the role of genetic factors such as the catechol-O-methyltransferase gene (COMT) influencing motivation, emotions, stress tolerance, self-control, sleep regulation, pain processing and perception, addictive behaviour and neurodegeneration, which may underlie differences in achieving remarkable results in sports competition. Thus, this study was performed to investigate the association between the COMT Val158Met (rs4680) polymorphism and athletic performance in Caucasian swimmers. A total of 225 swimmers (171 short distance (SDS) and 54 long distance swimmers (LDS)) of national or international competitive standard and 379 unrelated sedentary controls were genotyped using real-time polymerase chain reaction (real-time PCR). We found no significant differences in genotypic or allelic distributions between (1) male and female athletes; (2) SDS and LDS; (3) all athletes and sedentary controls (under codominant, dominant, recessive, and overdominant genetic models). No association was found between the COMT rs4680 polymorphism and elite swimming athlete status of the studied population. However, more replication studies are needed.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionsupporting

confidence: 53%

Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Żmijewski

Leońska-Duniec

Stuła

et al. 2021

Genes

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“…Of the 109 polymorphisms, only alpha actinin-3 ( ACTN3 ) rs1815739 was investigated in five studies, which found one meaningful genetic association [ 7 – 9 , 12 , 13 ]. Catechol-O-methyltransferase ( COMT ) rs4680 was investigated in 3 studies [ 17 – 19 ], of which one reported an association in martial art fighters [ 18 ]. Regarding angiotensin-converting enzyme ( ACE ) rs4646994, μ-opioid receptor ( OPRM1 rs1799971), and dopamine D4 receptor gene ( DRD4 Ex3 VNTR), two studies were analysed per polymorphoism [ 7 , 12 , 17 - 21 ]; two studies did not demonstrate that one specific gene alone was associated with combat sports [ 7 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Notably, the results for the COMT gene were contrasting. Leźnicka et al found no significant association ( p = 0.286 and p = 0.43) between COMT rs4680 GG genotype and elite combat sports athletes, suggesting that there was no difference between combat athletes and the control group in the aspect of pain perception [ 17 , 19 ]. On the other hand, Tartar et al found that the MMA group showed a significantly greater GG (warrior) phenotype frequency than the control group ( p = 0.003), suggesting that the warrior genotype may play a participation role in combat sports ( Table 2 ) [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Genetic basis of elite combat sports athletes: a systematic review

Youn¹,

Kim

2021

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Each athlete’s innate talent is widely recognized as one of the important contributors to achievement in athletic performance, and genetic factors determine a significant portion of talent or traits. Advances in DNA sequencing technology allow us to discover specific genetic variants contributing to these traits in sports performance. The objective of this systematic review is to identify genes that may play a significant role in the performance of elite-level combat sports athletes. Through the review of 18 full-text articles, a total of 109 different polymorphisms were investigated in 14,313 participants (2,786 combat sports athletes, 8,969 non-athlete controls, 2,558 other sports athletes). Thirteen polymorphisms showed a significant difference between elite combat athletes and the control group, and consist of 8 (PPARA rs4253778, ACTN3 rs1815739, ACE rs4646994, CKM rs8111989, MCT1 rs1049434, FTO rs9939609, GABP β 1 rs7181866 and rs8031031) oriented to athletic performance and 5 (COMT rs4680, FEV rs860573, SLC6A2 rs2242446, HTR1B rs11568817, ADRA2A rs521674) focused on psychological traits including emotional and mental traits in combat sports athletes. In addition, a recent whole genome sequencing study identified 4 polymorphisms (KIF27 rs10125715, APC rs518013, TMEM229A rs7783359, LRRN3 rs80054135) associated with reaction time in wrestlers. However, it is not clearly identified which genes are linked explicitly with elite combat sports athletes and how they affect the elite athlete’s status or performance in combat sports. Hence, a greater number of candidate genes should be included in future studies to practically utilize the genetic information.

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“…Genetic variation exerts an influence on every aspect of elite athlete performance, including training adaptation [ 1 ], injury risk [ 51 , 52 ], ergogenic aid use [ 2 ], post-exercise recovery [ 47 , 48 , 49 , 50 ], athletic development [ 3 ] and, at some point, potentially the identification of elite athletes. Additionally, researchers have identified the effects of genetic variation on important aspects such as skill acquisition [ 210 ], psychological traits [ 211 ] and post-exercise fatigue [ 50 ], along with tangential factors that may impact athletic performance and preparation, such as nutrient requirements [ 212 ], microbiome composition [ 213 ] and bone health [ 214 ]. As such, we can conclude that genetic influences are a fundamental and consistent modifier of athletic preparation, the harnessing of which should enhance the preparation process.…”

Section: A Centralised Framework For the Development Of A Personamentioning

confidence: 99%

The Development of a Personalised Training Framework: Implementation of Emerging Technologies for Performance

Pickering

Kiely

2019

JFMK

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Over the last decade, there has been considerable interest in the individualisation of athlete training, including the use of genetic information, alongside more advanced data capture and analysis techniques. Here, we explore the evidence for, and practical use of, a number of these emerging technologies, including the measurement and quantification of epigenetic changes, microbiome analysis and the use of cell-free DNA, along with data mining and machine learning. In doing so, we develop a theoretical model for the use of these technologies in an elite sport setting, allowing the coach to better answer six key questions: (1) To what training will my athlete best respond? (2) How well is my athlete adapting to training? (3) When should I change the training stimulus (i.e., has the athlete reached their adaptive ceiling for this training modality)? (4) How long will it take for a certain adaptation to occur? (5) How well is my athlete tolerating the current training load? (6) What load can my athlete handle today? Special consideration is given to whether such an individualised training framework will outperform current methods as well as the challenges in implementing this approach.

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The association between COMT rs4680 and OPRM1 rs1799971 polymorphisms and temperamental traits in combat athletes

Cited by 10 publications

References 21 publications

Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Genetic basis of elite combat sports athletes: a systematic review

The Development of a Personalised Training Framework: Implementation of Emerging Technologies for Performance

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