The Association Between Complete Blood Count and the Risk of Coronary Heart Disease

Abstract

oronary heart disease (CHD) remains a serious health problem. The reports revealed that CHD has caused 11.2% global deaths. Although crude mortality rate for CHD remains stable, this number increases rapidly with age. 1-3 Atherosclerosis of coronary arteries, the main cause of CHD, is a complex inflammatory disorder that causes the changes in the cells of the arterial wall and the blood components. 4,5 Several inflammatory biomarkers such as troponin, C reactive protein (CRP), and Btype natriuretic peptide (BNP) or pro-BNP are used to stratify the risk of The Association Between Complete Blood Count and the Risk of Coronary Heart Disease A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine the correlation between complete blood count and the risk of coronary heart disease (CHD). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : All CHD patients treated in Aisyiyah Hospital during January 2011 to December 2017 were enrolled for the study. Information related to demographic, clinical, and complete blood count were extracted from medical record. Multiple logistic regression test was employed to evaluate the correlation between complete blood count and CHD incidence. In addition, a meta-analysis was also conducted to summarize findings from other regions. R Re es su ul lt ts s: : A total of 516 CHD patients and 102 controls were included in our study. We found that elevated hemoglobin (OR 95%CI=4.92 [2.02-12.01], p=0.002), leukocyte (OR 95%CI=5.35 [3.17-9.03], p=0.001), hematocrit (OR 95%CI=2.31 [1.40-3.83], p=0.010), eosinophil (OR 95%CI= 2.78 [1.68-4.26], p=0.001), and monocyte (OR 95%CI=1.31 [0.80-2.16], p=0.023) were associated with the incidence of CHD. Furthermore, our meta-analysis revealed that elevated levels of leukocyte, eosinophil, and monocyte increased the risk of CHD approximately 3.57, 5.34, and 2.77 times, respectively. C Co on nc cl lu us si io on n: : There is strong evidence that elevated levels of leukocyte, eosinophil, and monocyte are the risk factor for CHD. K Ke ey yw wo or rd ds s: : Complete blood count; coronary heart disease; risk factor Ö ÖZ ZE ET T A Am ma aç ç: : Tam kan ayımı ile koroner kalp hastalığı (KKH) arasında korelasyon olup olmadığını araştırmak amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Aisyiyah Hastanesi'nde Ocak 2011-Aralık 2017 arasında tedavi gören tüm KKH hastaları çalışma kapsamına alındı. Hastalarla ilgili demografik bilgiler, klinik veriler ve tam kan sayımları tıbbi kayıtlardan alındı. Aradaki bağlantıyı incelemek için multipl lojistik regresyon analizi yapıldı. KKH insidansı analizine ilaveten diğer yayınlardan elde edilen özet verilerin meta-analizi yapıldı. B Bu ul lg gu ul la ar r: : Toplam 516 KKH hastası ve 102 kontrol kişisi çalışmaya alındı. KKH insidansı ile ilişkili olarak hemoglobin (OR %95 GA=4,

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