The association between common serum adipokines levels and postmenopausal osteoporosis: A meta‐analysis

Abstract

The clinical relevance of blood levels of adipokines in individuals with postmenopausal osteoporosis (PMOP) has not been previously clarified. We performed this meta‐analysis to clarify the association between three common adipokines levels and the occurrence of PMOP. PubMed, Embase, Cochrane library, and China National Knowledgement Infrastructure (CNKI) were searched for collecting articles published before 31 October 2021, without language and status restrictions. Fourteen studies met the selection criteria. Meta‐analysis revealed that blood leptin level was remarkably lower (mean difference [MD], −1.94; 95% confidence interval [CI], −3.83 to −0.06; I2 = 96%) and adiponectin level was remarkably higher (MD, 3.48; 95% CI, 2.36 to 4.60; I2 = 90%) in individuals with PMOP than healthy individuals with normal bone mineral density (BMD). However, the statistical difference in leptin level was changed after eliminating the confounding influence of leptin sources and assay approaches. Furthermore, a positive association (r = 0.28) between leptin level and body mass index (BMI) as well as a negative association (r = −0.33) between adiponectin level and BMD was found. Moreover, adiponectin had the highest probability of predicting PMOP (84%). Current evidence suggests that leptin positively affects BMI and adiponectin negatively affects BMD, and adiponectin is the most relevant adipokine negatively associated with PMOP.

Osteoporosis and Leptin: A Systematic Review

“…There was considerable heterogeneity of results in this meta-analysis, which may significantly weaken the validity of the results. However, this meta-analysis had strong points, such as the relationships between three common adipokines with the occurrence of PMOP were investigated, and at the same time, the differences in the levels of adipokines and the relationships of different adipokines with BMD and BMI were estimated, and the quality of the included studies was average ( 13 ). Evidence from another systematic review and meta-analysis showed that leptin had a significant positive association with BMD and BMC in all populations, except in boys, especially in girls and postmenopausal women.…”

“…Given that the relationship between serum leptin levels and bone metabolism is complex, no definitive conclusions have been drawn on this issue ( 12 , 13 ). As far as we know studies that have examined both human and animal studies to determine the relationship between leptin serum level and BMD is necessary to reach a more specific result.…”

Research Progress on the Pathogenesis of Type 2 Diabetes-Related Osteoporosis

“…Knockout mice lacking chemerin receptors CMKLR1 and GPR1 show reduced bone mass and osteoblast differentiation, indicating that chemerin signaling plays a significant role in regulating bone formation in the body [31]. Adiponectin shows a significant negative correlation with bone density [32]. Adiponectin, with a protein structure, is a hormone synthesized by adipocytes.…”

Nghiên cứu mối liên quan giữa mật độ xương với khối mỡ, khối nạc, nồng độ leptin, adiponectin huyết thanh ở người trên 40 tuổi có hội chứng chuyển hóa

“…Ansari MGA, (2020) nồng độ leptin cho thấy không có mối liên quan đáng kể nào với MĐX [9]. Linyuan S, (2022), không có sự khác biệt về nồng độ leptin với MĐX sau khi loại bỏ ảnh hưởng gây nhiễu [10].…”