The association between cognitive impairment and physical disability in                 multiple sclerosis

Lynch, Sharon G.; Parmenter, Brett A.; Denney, Douglas R.

doi:10.1191/1352458505ms1182oa

Cited by 110 publications

(87 citation statements)

References 38 publications

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“…The patients had a mean of 52 points, very close to our 48.2. In other studies, this findings was similar, ranging from 42 to 51.6 points 12,22,23,24,25 . Only one paper 13 showed a significant discrepancy, with a mean in the CVLT of 64 in patients with MS 2 .…”

supporting

confidence: 73%

“…Draws attention the fact that in this study there was no significant difference between MS patients and healthy controls in the CVLT, with a mean of 66.5 points, a result that has not been replicated in subsequent studies 4,20 . A consistent association between the CVLT and EDSS, with a coefficient r of -0.30, was shown in a study by Lynch et al 12 This coefficient, which was statistically significant, is lower than ours; however is important to consider the differences in methodology and number of patients in the samples between the studies. Table 4 shows the comparison between our results and the CVLT obtained in earlier studies in patients with MS.…”

mentioning

confidence: 62%

“…This concept was subsequently corroborated by studies characterized by a great heterogeneity in the samples and methodologies 13 . Currently, despite some conflict about the association between cognitive impairment and the physical state 9 , there are several studies suggesting a cognitive decline that is definitely identifiable by neuropsychological tests, and correlated with the disability state in MS 5,9,10,12,14 . Cognitive complaints are rarely considered in routine evaluation.…”

mentioning

confidence: 99%

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The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

Caneda

Vecino

2016

Arq. Neuro-Psiquiatr.

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Multiple sclerosis (MS) may present with a cognitive impairment as disabling as the physical disabilities. Therefore, routine cognitive evaluation is pivotal. Valid and reliable neuropsychological tests are essential in follow-up and to define future therapeutic interventions. Objectives To investigate the correlation between the disabilities of MS patients and their cognitive impairment assessed by the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Methods Forty patients with definitive diagnoses of MS were selected. The correlation coefficient (r) between the Expanded Disability Status Scale (EDSS) and the neuropsychological tests of BICAMS were calculated. Results The correlation was clinically substantial and significant with r = 0.55 (p < 0.01) in the Symbol Digit Modalities Test (SDMT), 0.54 (p < 0.01) in the Brief Visuospacial Memory Test (BVMT) and 0.40 (p < 0.05) in the California Verbal Learning Test (CVLT). Conclusion BICAMS has easy and satisfactory application and evaluation for routine visits and presents a significant correlation with the EDSS. Its use may be indicated for screening and monitoring of cognitive impairment in patients with MS.

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supporting

confidence: 73%

mentioning

confidence: 62%

mentioning

confidence: 99%

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The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

Caneda

Vecino

2016

Arq. Neuro-Psiquiatr.

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“…14 Fatigue and cognitive deficits are associated with disability. 15,16 Although fatigue and cognition are not explicitly captured by the Expanded Disability Status Scale (EDSS), a reduction in sustained disability progression as measured by the EDSS is seen with natalizumab as compared with placebo. 13 Here we report findings from the Evaluation of Natalizumab for thE Relief of MS Associated FatiGue (ENER-G) study, which was designed to evaluate changes in and correlations between fatigue and cognition in natalizumab-treated patients with relapsing MS.…”

Section: Interventions and Assessmentsmentioning

confidence: 99%

Changes in Fatigue and Cognition in Patients with Relapsing Forms of Multiple Sclerosis Treated with Natalizumab

Wilken¹,

Kane²,

Sullivan³

et al. 2013

International Journal of MS Care

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“…4 Physical disability and the presence of cognitive deficits are not strongly correlated in MS, 12 but cognitive impairment may be predictive of physical progression of the disease. 13 Magnetic resonance imaging findings associated with cognitive dysfunction include indices of whole-brain atrophy and overall lesion burden (as reviewed by Rao). 11 Measurement of third-ventricle width (an index of atrophy) has been shown to be predictive of cognitive impairment in individuals with a relapsing-remitting course.…”

Section: Cognitive Domains Commonly Affected In Msmentioning

confidence: 99%

Neuropsychologist

Fuchs¹

2009

International Journal of MS Care

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32 Multiple sclerosis (MS) is a disease of the central nervous system with prominent physical symptoms such as muscle weakness and spasticity that lead to limitations in mobility. 1 Although MS care often focuses on the assessment and treatment of these physical symptoms, changes in cognition can be of greater concern to people with MS and their families. It is believed that at least half of people with MS eventually experience some degree of cognitive dysfunction, 2 which can occur early in the disease and progress over an interval as short as 2 years. 3 Cognitive impairment in MS is associated with loss of employment, 4 reduced driving skills, 5 diminished socialization, 6 and dependence on others for activities of daily living (ADLs). 4 Subtle changes in cognitive efficiency may be readily noticed by a person with MS but overlooked by health-care providers and misunderstood by family members and coworkers. For this reason, cognitive dysfunction is often referred to as an "invisible" symptom of MS. Because cognitive decline may not be readily apparent at bedside examination, 7 a neuropsychological evaluation can be invaluable in providing information about brain function to people with MS and their health-care teams. Additionally, test results can be used to support an application for disability benefits or school/work accommodation. Repeat testing can identify changes or stability over time, following relapses, or with treatment. Test results can also guide development of compensation strategies. In addition to conducting a cognitive evaluation, neuropsychologists can provide treatment in the form of individual psychotherapy, family counseling, behavior management, and cognitive rehabilitation. What Is Neuropsychology?A clinical neuropsychologist is a licensed psychologist with specialized training in the relationship between brain functioning and abilities such as memory, attention, language, and reasoning. Following completion of a doctoral program, neuropsychologists undergo further training and supervision in the practice of neuropsychology through a clinical internship and then a 2-year postdoctoral residency or fellowship. Clinical neuropsychology is a specialty recognized by the American and Canadian Psychological Associations. After completion of training and a period of independent practice, an individual can go through the examination process to be certified through the American Board of Professional Psychology.The primary clinical service provided by neuropsychologists to people with MS is assessment of cognitive functioning. While a magnetic resonance imaging or computed tomographic scan can provide information about the structural integrity of the brain, a neuropsychological evaluation documents functional capacity. Neuropsychologists typically administer a series of stan-

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The association between cognitive impairment and physical disability in multiple sclerosis

Cited by 110 publications

References 38 publications

The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

Changes in Fatigue and Cognition in Patients with Relapsing Forms of Multiple Sclerosis Treated with Natalizumab

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