The association between cognitive deficits and depressive symptoms in at-risk mental state: A comparison with first-episode psychosis

Ohmuro, Noriyuki; Matsumoto, Kazunori; Katsura, Masahiro; Obara, Chika; Kikuchi, Tatsuo; Hamaie, Yumiko; Sakuma, Atsushi; Iizuka, Kunio; Ito, Fumiaki; Matsuoka, Hiroo

doi:10.1016/j.schres.2015.01.008

Cited by 21 publications

(11 citation statements)

References 59 publications

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“…In addition, Niendam et al (2006) made use of the conservative Bonferroni correction. However, the associations observed by Niendam et al (2006) and Ohmuro et al (2015) showed the same pattern as in studies reporting significant associations.…”

Section: Discussionsupporting

confidence: 80%

“…These results are consistent with most previous studies investigating the associations between psychopathological symptoms and cognitive functioning in ARMS (Gur et al, 2015;Lindgren et al, 2010;Meyer et al, 2014) and FEP patients (de Gracia Dominguez et al, 2009). However, not all performed studies have found associations between negative symptoms and cognitive deficits among ARMS patients (Kim et al, 2011;Niendam et al, 2006;Ohmuro et al, 2015;Pukrop et al, 2007). This might be due to the rather small sample sizes in those studies.…”

Section: Discussionmentioning

confidence: 91%

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The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

Leanza

Egloff

Studerus

et al. 2018

Psychiatry Research

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Negative symptoms and neurocognitive performance have been reported to be negatively associated in patients with emerging psychosis. However, most previous studies focused on patients with frank psychosis and did not differentiate between subdomains of negative symptoms. Hence, we aimed to elucidate the specific relationship between negative symptoms and cognitive functioning in patients at clinical high risk (CHR) for psychosis. Data from 154 CHR patients collected within the prospective Früherkennung von Psychosen (FePsy) study were analyzed. Negative symptoms were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and cognitive functioning with an extensive neuropsychological test battery. Regression analyses revealed significant negative associations between negative symptoms and cognitive functioning, particularly in the domains of nonverbal intelligence and verbal fluency. When analyzing each negative symptom domain separately, alogia and asociality/anhedonia were significantly negatively associated with nonverbal intelligence and alogia additionally with verbal fluency. Overall, our results in CHR patients are similar to those reported in patients with frank psychosis. The strong negative association between verbal fluency and negative symptoms may be indicative of an overlap between these constructs. Verbal fluency might have a strong influence on the clinical impression of negative symptoms (particularly alogia) and vice versa.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 91%

The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

Leanza

Egloff

Studerus

et al. 2018

Psychiatry Research

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“…Depressive symptoms may therefore be experienced as subjectively more severe and/or distressing in FES than what is typically observed. Indeed, previous research indicated that the severity of depressive symptoms corresponded to moderate on self-report and mild on an interviewer-rated instrument in the same first-episode cohort (Ohmuro et al ., 2015). This phenomenon may be reflective of depressive psychopathology being overlooked and therefore underestimated in FES.…”

Section: Discussionmentioning

confidence: 99%

Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression

et al. 2019

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BackgroundDespite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum disorders (FES), there is limited knowledge regarding the extent and nature of such psychopathology (degree of comorbidity, caseness, severity) and its demographic, clinical, functional and treatment correlates. This study aimed to determine the pooled prevalence of depressive disorder and caseness, and the pooled mean severity of depressive symptoms, as well as the demographic, illness, functional and treatment correlates of depressive psychopathology in FES.MethodsThis systematic review, meta-analysis and meta-regression was prospectively registered (CRD42018084856) and conducted in accordance with PRISMA and MOOSE guidelines.ResultsForty studies comprising 4041 participants were included. The pooled prevalence of depressive disorder and caseness was 26.0% (seven samples, N = 855, 95% CI 22.1–30.3) and 43.9% (11 samples, N = 1312, 95% CI 30.3–58.4), respectively. The pooled mean percentage of maximum depressive symptom severity was 25.1 (38 samples, N = 3180, 95% CI 21.49–28.68). Correlates of depressive psychopathology were also found.ConclusionsAt least one-quarter of individuals with FES will experience, and therefore require treatment for, a full-threshold depressive disorder. Nearly half will experience levels of depressive symptoms that are severe enough to warrant diagnostic investigation and therefore clinical intervention – regardless of whether they actually fulfil diagnostic criteria for a depressive disorder. Depressive psychopathology is prominent in FES, manifesting not only as superimposed comorbidity, but also as an inextricable symptom domain.

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“…In previous studies on schizophrenia samples, anxiety has not been found to associate with cognitive performance (Aikawa et al, 2018;Buonocore et al, 2018). In one study, depression was found to be associated with decreased cognitive speed but not motor speed or working memory in schizophrenia (Brébion et al, 2009), but in FEP, no association between neuropsychological functioning and depressive symptoms has been detected (Lucas et al, 2004;Ohmuro et al, 2015). A systematic review found no association between neurocognition and depression related to lifetime occurrence of psychosis (Dominguez et al, 2009).…”

Section: Introductionmentioning

confidence: 95%

Is cognitive performance associated with anxiety and depression in first-episode psychosis?

Lindgren

Birling

Kieseppä

et al. 2020

Journal of Affective Disorders

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Background: In first-episode psychosis (FEP), symptoms of anxiety and depression are common. We examined whether cognitive performance is associated with these clinical measures in FEP during a one-year follow-up. Methods: Young adults with non-affective FEP (n = 52) were assessed two months after their first psychiatric contact for psychosis. Matched controls (n = 62) were administered a baseline assessment. 32 FEP subjects and 44 controls were assessed again at a one-year follow-up. In both assessments, a broad neuropsychological test battery was administered. Clinical evaluation was done with the Brief Psychiatric Rating Scale. Cross-sectional correlations were calculated at both time points. Cognitive test scores were used as independent variables in regression models, predicting both baseline and follow-up symptom levels. Results: At baseline, better performance especially in verbal memory and executive functioning was associated with elevated anxiety symptoms in FEP. In addition, better performance especially in verbal working memory was associated with depression. A year later, better cognitive performance was no longer associated with affective symptoms. Limitations: Small sample sizes are a limitation. Conclusions: In the FEP group, higher cognitive performance associated with affective symptoms. Right after getting severely ill, anxiety and depression may be a part of normal adaptive reactions to the situation and markers of an intact cognitive performance. This association seems to cease during the year following the FEP.

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The association between cognitive deficits and depressive symptoms in at-risk mental state: A comparison with first-episode psychosis

Cited by 21 publications

References 59 publications

The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression

Is cognitive performance associated with anxiety and depression in first-episode psychosis?

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