Is cognitive performance associated with anxiety and depression in first-episode psychosis?

Lindgren, Maija; Birling, Heli; Kieseppä, Tuula; Tuulio‐Henriksson, Annamari

doi:10.1016/j.jad.2019.11.161

Cited by 14 publications

(19 citation statements)

References 44 publications

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“…Menopause-related estrogen decline also increases the risk of cognitive impairment [42]. This finding is in agreement with those of Lindgren et al [43], who found associations between affective symptoms and poorer cognitive performance, but unlike in our study, the correlations did not reach statistical significance. Similarly, previous studies have shown the association between anxiety and depression with cognitive performance in the general population [44,45], with some pathology such as Parkinson's [46].…”

Section: Discussionsupporting

confidence: 91%

Associations of Sleep Quality, Anxiety, and Depression with Cognitive and Executive Functions among Community-Dwelling Women Aged ≥ 65 Years: A Cross-Sectional Study

et al. 2021

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(1) Background: The objective of this study was to evaluate the associations of sleep quality, anxiety, and depression with cognitive performance, executive functions, and verbal fluency among women aged ≥ 65 years; (2) Methods: A cross-sectional study was conducted on 241 women (72.52 ± 3.93 years). Cognitive performance (Mini-Mental State Examination) and impairment (Montreal Cognitive Assessment), verbal fluency (Isaacs test) and executive function (Trail Making Test), Sleep quality (Pittsburgh Sleep quality Index) and anxiety and depression (Hospital Anxiety and Depression Scale) were determined; (3) Results: The linear regression analysis indicated that anxiety, depression and age, were related to lower Mini-Mental State Examination score (adjusted R2 = 0.306), and age, anxiety and daytime dysfunction were linked to reduced Montreal Cognitive Assessment score (adjusted R2 = 0.248). Age and daytime dysfunction were associated with worse verbal fluency (adjusted R2 = 0.094). Finally, sleep latency, sleep disturbances, the Pittsburgh Sleep quality Index total score were associated with longer times in TMT-A (adjusted R2 = 0.758) and TMT-B (adjusted R2 = 0.508); (4) Conclusions: Sleep quality was associated with cognitive performance, verbal fluency and executive functions. Besides, both anxiety and depression were related with cognitive performance, while only anxiety was linked to executive functions. As for confounders, age was associated with cognitive performance and verbal fluency.

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Section: Discussionsupporting

confidence: 91%

Associations of Sleep Quality, Anxiety, and Depression with Cognitive and Executive Functions among Community-Dwelling Women Aged ≥ 65 Years: A Cross-Sectional Study

et al. 2021

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“…Generally, affective symptoms in FEP may associate with a more severe clinical picture (70). Our previous results suggest that affective symptoms right after getting ill may associate with better cognitive performance (26) as well as with a better functional 1-year outcome (27), which possibly relates to better insight into the situation that evokes negative emotions and a better understanding of the situation. Positive symptoms of psychosis are seldom associated with cognitive functioning (54), and they also seem to interfere with everyday functioning less than negative symptoms (21).…”

Section: Discussionmentioning

confidence: 91%

“…Affective symptoms in psychotic disorders may also be linked to poorer cognition (22)(23)(24), but in some studies, the direction of the association has also been the reverse (25). We have previously found higher affective symptoms to associate with better cognitive performance right after getting ill (26) and with a better functional 1-year outcome in FEP (27), suggesting that anxiety and depression do not necessarily signal a poor prognosis in FEP.…”

Section: Introductionmentioning

confidence: 97%

Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis

et al. 2020

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Cognitive performance at illness onset may predict outcomes in first-episode psychosis (FEP), and the change in cognition may associate with clinical changes. Cognitive testing was administered to 54 FEP participants 2 months after entering treatment and to 39 participants after 1 year. We investigated whether baseline cognition predicted 1-year outcomes beyond positive, negative, and affective symptoms and whether the trajectory of cognition associated with clinical change. Baseline overall neurocognitive performance predicted the 1-year social and occupational level, occupational status, and maintaining of life goals. The domain of processing speed associated with the 1-year remission, occupational status, and maintaining of life goals. Baseline social cognition associated with occupational status a year later and the need for hospital treatment during the 1st year after FEP. Most of the associations were retained beyond baseline positive and affective symptom levels, but when accounting for negative symptoms, cognition no longer predicted 1-year outcomes, highlighting how negative symptoms overlap with cognition. The trajectory of neurocognitive performance over the year did not associate with changes in symptoms or functioning. Cognitive testing at the beginning of treatment provided information on the 1-year outcome in FEP beyond positive and affective symptom levels. In particular, the domains of processing speed and social cognition could be targets for interventions that aim to improve the outcome after FEP.

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“…Previous studies suggest that anxiety has a negative impact on the severity of positive and negative symptoms, social and overall function and global quality of life (Braga, Mendlowicz, Marrocos, & Figueira, 2005;Huppert, Weiss, Lim, Pratt, & Smith, 2001;Karpov et al, 2017;McEnery et al, 2019;Pallanti, Quercioli, & Hollander, 2004).On the other hand, higher anxiety has been associated with better treatment-decision capacity and insight (Larkin & Hutton, 2017;Wiffen, Rabinowitz, Lex, & David, 2010). We have previously found that anxiety in FEP associate with higher cognitive performance at the early stage of illness but not at 12 months (Lindgren, Birling, & Kieseppä, 2020). However, the potential significance of anxiety in predicting remission and long-term functioning in FEP has rarely been studied.…”

Section: Introductionmentioning

confidence: 77%

Anxiety symptoms in first‐episode psychosis

Karpov

Kieseppä

Lindgren

et al. 2020

Early Intervention Psych

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Aim: Anxiety disorders and symptoms are common in people with psychotic disorders, having a negative impact on clinical status, function level and overall prognosis. However, research on the significance of anxiety in predicting remission and long-term functioning in first-episode psychosis (FEP) is still scarce. This study investigated the effects of anxiety and obsessive-compulsive symptoms (OCS) on clinical and functional improvement in individuals with FEP.Methods: FEP patients (N = 97) aged 18-40 years were recruited from the University Hospital District of Helsinki and the City of Helsinki. Psychotic and anxiety symptoms were measured using the Brief Psychiatric Rating Scale.Obsessive-compulsive symptoms were assessed using the Obsessive-Compulsive Inventory (OCI-R), and functioning was evaluated using the Social and Occupational Functioning Assessment Scale (SOFAS). Follow-up measurements were performed at 2 and 12 months. We specifically studied whether anxiety and obsessive-compulsive symptoms at the 2-month follow-up assessment, at a time when the initial treatment response had been achieved, would predict outcomes at 12 months.Results: Symptoms of anxiety and OCS correlated moderately with each other and psychotic symptoms, but at the 12-month follow-up, OCS no longer correlated significantly with psychotic and anxiety symptoms. When the level of psychotic symptoms was adjusted for, more severe OCS at the 2-month follow-up was associated with a lower rate of remission at 12 months, whereas a higher level of anxiety symptoms at 2 months was associated with better functioning at 12 months.Conclusions: OCS may be predictive of poorer clinical outcomes, whereas anxiety symptoms may predict better functional outcomes.

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Is cognitive performance associated with anxiety and depression in first-episode psychosis?

Cited by 14 publications

References 44 publications

Associations of Sleep Quality, Anxiety, and Depression with Cognitive and Executive Functions among Community-Dwelling Women Aged ≥ 65 Years: A Cross-Sectional Study

Associations of Sleep Quality, Anxiety, and Depression with Cognitive and Executive Functions among Community-Dwelling Women Aged ≥ 65 Years: A Cross-Sectional Study

Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis

Anxiety symptoms in first‐episode psychosis

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