The association between BMI and cervical cancer risk

Poorolajal, Jalal; Jenabi, Ensiyeh

doi:10.1097/cej.0000000000000164

Cited by 87 publications

(65 citation statements)

References 35 publications

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“…Several studies which validate the detrimental effects of overweight or obesity in cervical cancer patients have been reported [10,13,23]. A recent meta-analysis showed that higher BMI was clinically related with cervical cancer risk [10].…”

Section: Discussionmentioning

confidence: 99%

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Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy

et al. 2017

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PurposeThis study aimed to assess the effects of body mass index (BMI) on survival in cervical cancer patients who had undergone surgery and radiotherapy (RT).Materials and MethodsWe retrospectively reviewed the medical records of 70 cervical cancer patients who underwent surgery and RT from 2007 to 2012. Among them, 40 patients (57.1%) had pelvic lymph node metastases at the time of diagnosis. Sixty-seven patients (95.7%) had received chemotherapy. All patients had undergone surgery and postoperative RT. Median BMI of patients was 22.8 kg/m2 (range, 17.7 to 35.9 kg/m2).ResultsThe median duration of follow-up was 52.3 months (range, 16 to 107 months). Twenty-four patients (34.3%) showed recurrence. Local failure, regional lymph nodal failure, and distant failure occurred in 4 (5.7%), 6 (8.6%), and 17 (24.3%) patients, respectively. The 5-year actuarial pelvic control rate was 83.4%. The 5-year cancer-specific survival (CSS) and disease-free survival (DFS) rates were 85.1% and 65.0%, respectively. The presence of pelvic lymph node metastases (n = 30) and being overweight or obese (n = 34, BMI ≥ 23 kg/m2) were poor prognostic factors for CSS (p = 0.003 and p = 0.045, respectively). Of these, pelvic lymph node metastasis was an independent prognostic factor (p = 0.030) for CSS.ConclusionOverweight or obese cervical cancer patients showed poorer survival outcomes than normal weight or underweight patients. Weight control seems to be important in cervical cancer patients to improve clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis showed that higher BMI was clinically related with cervical cancer risk [10]. Clark et al [13] also showed that excess body mass index (BMI ≥ 25 kg/m 2 ) was associated with worse survival in cervical cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy

et al. 2017

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“…Poorolajal and Jenabi (2015) stated that overweight is not associated with an increased risk of cervical cancer, but the weak obesity associated to increase risk of cervical cancer. Based on Cohort study, to providing conclusive evidence of whether or not BMI associated with an increased risk of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Multilevel Analysis on the Social Determinants of Cervical Cancer in Yogyakarta

Sari¹,

Mudigdo

Demartoto

2016

J EPIDEMIOL PUBLIC HEALTH

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Background: There are 527,600 new cases of invasive cervical cancer. Cervical cancer is caused by infection with the Human Papilloma Virus (HPV) 16 and 18 study was conducted in the city of Yogyakarta. This study aimed to analyze the social determinants on cervical cancer by multilevel analysis in Yogyakarta. Subjects and Method: This was an observational analytic study with case control design. This was conducted on March 31 to May 4, 2016. A total of 120 samples were selected by fixed disease sampling with a ratio 1:3. The data collected was using a questionnaire and analyzed with Logistic Regression. Results: The risk of cervical cancer with a positive effect on family income (OR = 3.45; 95% CI = 0.26 to 45.45; p=0.346), age of first sexual intercourse (OR = 8.54; 95% CI = 1.17 to 62.41; p= 0.034), number of sexual partners (OR=14.60; 95% CI = 2.93 to 72.66; p= 0.001), oral contraceptives (OR = 1.85; 95% CI=0.37 to 9.20; p=0452), nutritional status (OR= 5.69; 95% CI=1.36 to 23.82; p = 0.017), hygiene genitalia (OR = 9.23; 95% CI = 1.76 to 48.35; p= 0.009), and an effect reversed by education (OR = 0.14; 95% CI=0.09 to 2.08; p=0.155). ICC value of 40.68% indicating the risk of cervical cancer in women varies and a variation of 40.68% at the level of environmental sanitation home. Conclusion: There is a positive effect of family income, age of first sexual intercourse, number of sexual partners, nutritional status, hygiene genitalia, and sanitary home environment, on the risk of cervical cancer.There is an inverse effect of education on the risk of cervical cancer. The society is expected to be aware of cervical cancer.

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“…Obesity increases the risk of cervical carcinoma and is important in the incidence of cervical adenocarcinoma associated with hormonal risk factors (Lacey et al, 2003;Lee et al, 2013;Poorolajal and Jenabi, 2016). In a case control study, the risk of developing cervix adenocarcinoma in obese women with body mass index (BMI ≥30) and overweight women (BMI ≥25) was 2-fold higher than for other women (Lacey et al, 2003).…”

Section: -Obesitymentioning

confidence: 99%

Incidence, mortality and risk factors of cervical cancer in the world

Momenimovahed

Salehiniya

2017

Biomed. Res. Ther.

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Background: Cervical cancer imposes a huge global burden. To date, various studies have been conducted on the risk factors associated with cervical cancer. The aim of this study was to investigate the incidence, mortality, and geographical distribution of cervical cancer and its risk factors in the world. Methods: A literature search was conducted using PubMed, Web of sciences, Scopus, and Google Scholar to search for studies published between 2000 and 2017. The keywords used included cervical cancer, cervix uteri cancer, risk factor, incidence, mortality, and a combination of these terms. Results: The results of this study showed that the incidence of cervical cancer varies considerably between developed and developing countries. The findings of this study demonstrated that several factors including sexually transmitted infections, reproductive factors, hormonal influences, genetics and host factors are responsible for the incidence of cervical cancer. Conclusion: The results of this review study suggested that combination of biological, economic and health factors contributes to the incidence of cervical cancer. A large proportion cervical cancer can be prevented by prevention programs, lifestyle enhancement, smoking cessation, and timely and effective treatment of precancerous lesions.

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The association between BMI and cervical cancer risk

Cited by 87 publications

References 35 publications

Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy

Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy

Multilevel Analysis on the Social Determinants of Cervical Cancer in Yogyakarta

Incidence, mortality and risk factors of cervical cancer in the world

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