The association between blood pressure components and cognitive functions and cognitive reserve

Alipour, Houman; Goldust, Mohamad

doi:10.3109/10641963.2015.1047946

Cited by 17 publications

(15 citation statements)

References 32 publications

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“…Recent studies also showed that high‐salt intake significantly correlated with an increase in mental stress, and decrease in plasma renin activity among young healthy individuals with normal blood pressure . Some studies showed a significant correlation between hypertension and cognitive decline …”

Section: Association Of Cognitive Impairment With Inflammatory Conditmentioning

confidence: 99%

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

Abdoli

2017

Clinical & Exp Neuroim

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Salt is an important macronutrient that plays pivotal roles in physiological and pathophysiological conditions. High salt intake is an important cause of hypertension, cardiovascular disease and stroke. However, recent investigations uncovered the role of excessive salt intake in the induction of severe inflammatory reactions through augmentation of T helper-17 pathway and their inflammatory cytokines. In contrast, numerous studies have shown the role of inflammation in the pathophysiology of neuropsychiatric disorders (NPD). Here, it is hypothesized that high salt intake can increase the risk of NPD through salt-derived neural inflammations. Therefore, this hypothesis suggests that low-salt intake can decrease the risk of NPD. The present review discusses the potential role of excessive salt intake in the pathophysiology of NPD.

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Section: Association Of Cognitive Impairment With Inflammatory Conditmentioning

confidence: 99%

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

Abdoli

2017

Clinical & Exp Neuroim

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“…With an apparent association between poorer cardiovascular function and cerebral structural integrity, it follows that poorer cardiovascular function is predictive of reduced cognitive function. Elevated BP has been observed to predict poorer cognitive performance as well as an increased risk of developing MCI or dementia (Launer et al, 2000 ; Whitmer et al, 2005 ; Köhler et al, 2014 ; Chen et al, 2015 ; Alipour and Goldust, 2016 ) with similar effects having been observed in adults with elevated AS (Singer et al, 2014 ; Hajjar et al, 2016 ; Lim et al, 2016 ; Pase et al, 2016 ; Meyer et al, 2017 ). Given that there is a preponderance for increased BP (Neaton and Wentworth, 1992 ; Lloyd-Jones et al, 2005 ) and AS (Benetos et al, 2002 ; Mitchell et al, 2004 ) with age, targeting these outcomes with nutritional interventions may be benefit cerebral structural integrity, and therefore cognitive function in older adults.…”

Section: Gpl Supplementation As a Means Of Supporting Cerebral Structmentioning

confidence: 99%

Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults

Reddan

White

Macpherson

et al. 2018

Front. Aging Neurosci.

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Modifying nutritional intake through supplementation may be efficacious for altering the trajectory of cerebral structural decline evident with increasing age. To date, there have been a number of clinical trials in older adults whereby chronic supplementation with B vitamins, omega-3 fatty acids, or resveratrol, has been observed to either slow the rate of decline or repair cerebral tissue. There is also some evidence from animal studies indicating that supplementation with glycerophospholipids (GPL) may benefit cerebral structure, though these effects have not yet been investigated in adult humans. Despite this paucity of research, there are a number of factors predicting poorer cerebral structure in older humans, which GPL supplementation appears to beneficially modify or protect against. These include elevated concentrations of homocysteine, unbalanced activity of reactive oxygen species both increasing the risk of oxidative stress, increased concentrations of pro-inflammatory messengers, as well as poorer cardio- and cerebrovascular function. As such, it is hypothesized that GPL supplementation will support cerebral structure in older adults. These cerebral effects may influence cognitive function. The current review aims to provide a theoretical basis for future clinical trials investigating the effects of GPL supplementation on cerebral structural integrity in older adults.

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“…Specifically, memory, processing speed and executive function will be examined as each of these is sensitive to age-related decline, and task performance is predictive of cognitive ageing and risk of dementia and Alzheimer’s disease [ 30 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ]. Further, these cognitive functions are negatively affected by hypertension, endothelial dysfunction, atherosclerosis and CVD [ 10 , 103 , 104 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 ].…”

Section: Introductionmentioning

confidence: 99%

A Mediterranean Diet to Improve Cardiovascular and Cognitive Health: Protocol for a Randomised Controlled Intervention Study

et al. 2017

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The Mediterranean diet has demonstrated efficacy for improving cardiovascular and cognitive health. However, a traditional Mediterranean diet delivers fewer serves of dairy and less dietary calcium than is currently recommended in Australia, which may limit long-term sustainability. The present study aims to evaluate whether a Mediterranean diet with adequate dairy and calcium can improve cardiovascular and cognitive function in an at-risk population, and thereby reduce risk of cardiovascular disease (CVD) and cognitive decline. A randomised, controlled, parallel, crossover design trial will compare a Mediterranean diet supplemented with dairy foods against a low-fat control diet. Forty participants with systolic blood pressure above 120 mmHg and at least two other risk factors of CVD will undertake each dietary intervention for eight weeks, with an eight-week washout period between interventions. Systolic blood pressure will be the primary measure of interest. Secondary outcomes will include measures of cardiometabolic health, dietary compliance, cognitive function, assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB), psychological well-being and dementia risk. This research will provide empirical evidence as to whether the Mediterranean diet can be modified to provide recommended dairy and calcium intakes while continuing to deliver positive effects for cardiovascular and cognitive health. The findings will hold relevance for the field of preventative healthcare and may contribute to revisions of national dietary guidelines.

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The association between blood pressure components and cognitive functions and cognitive reserve

Abstract: This study contributes to the belief that a link exists between BP and cognition, higher values of systolic BP being associated to impaired cognitive function.

Cited by 17 publications

References 32 publications

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults

A Mediterranean Diet to Improve Cardiovascular and Cognitive Health: Protocol for a Randomised Controlled Intervention Study

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