The association between anatomic site and survival in malignant melanoma. An analysis of 12,353 cases from the Swedish cancer registry

Thörn, Magnus; Adami, Hans‐Olov; Ringborg, Ulrik; Bergström, Reinhold; Krusemo, Ulla Brith

doi:10.1016/0277-5379(89)90261-7

Cited by 73 publications

(40 citation statements)

References 21 publications

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“…Nonetheless, we are able to discuss our findings in the context of several published studies of more than 1000 patients using multivariate Cox modeling to elucidate the influence of scalp, neck, or head/neck location on melanoma prognosis. Three European populationbased studies 6,18,19 reached mixed conclusions. Thö rn et al 6 found that among 12 353 Swedish patients with melanoma, the highest relative hazards for death were for scalp/ neck tumors in males and trunk lesions in females after controlling for age and year of diagnosis.…”

Section: Commentmentioning

confidence: 99%

“…3 However, the prognostic significance of tumor location, especially the scalp or neck (scalp/neck) region, has been debated for decades. [4][5][6][7] Understanding the role of anatomic site in melanoma survival is important for public health messages on skin awareness and sun protection. Moreover, because the role of screening in melanoma is considered important for early detection, 8,9 it is useful to clarify those characteristics with prognostic significance.…”

mentioning

confidence: 99%

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Survival Differences Between Patients With Scalp or Neck Melanoma and Those With Melanoma of Other Sites in the Surveillance, Epidemiology, and End Results (SEER) Program

Lachiewicz¹,

Berwick²,

Wiggins³

et al. 2008

Arch Dermatol

240

210

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Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

Survival Differences Between Patients With Scalp or Neck Melanoma and Those With Melanoma of Other Sites in the Surveillance, Epidemiology, and End Results (SEER) Program

Lachiewicz¹,

Berwick²,

Wiggins³

et al. 2008

Arch Dermatol

240

210

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“…Age at diagnosis was grouped into six categories: under 30years, 30 to 39, 40 to 49, 50 to 59, 60 to 69 and 70 and above. 8 Site was classified into head and neck (H/N), trunk, upper limb (UL) and lower limb (LL). Eyelid and ears were considered part of the head and neck category.…”

Section: Methodsmentioning

confidence: 99%

Differences in survival by race/ethnicity among cutaneous melanoma patients in the United States over a period from 1982 to 2011

2018

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Background: Melanoma is an aggressive skin cancer with a high mortality rate. The incidence of melanoma has increased in recent years from 1:1500 in 1935 to 1:50 in 2011. The aim of this study is to investigate survival by race/ethnicity, taking site into account, among melanoma patients in the United States.Methods: This study is a secondary analysis of the Surveillance, Epidemiology, and End Results (SEER) Program. SEER collects data through a non-concurrent cohort study design. The sample size was 185219 participants. The chi-square test was used to examine the association between categorical variables. Kaplan-Meier survival analysis was used to estimate the overall survival curve and to estimate the survival curve per race/ethnicity. Collinearity was assessed using Pearson correlation. Cox proportional hazards regression was used to calculate the unadjusted and adjusted hazard ratios (HR).Results: Non-Hispanic White (NHW) and Other patients were older in age (70 years or older), while non-Hispanic Black (NHB) and Hispanic patients were younger (30-39 years). Melanoma in NHW patients was mostly located in trunk whereas melanoma for NHB, Hispanic and Other patients was mostly located in the lower limbs. For all races/ethnicities except for NHB, more individuals were diagnosed between 2002 and 2011. Patients with melanoma in upper limbs lived more frequently. Fewer women died (6.8%) compared to men (17.1%). Patients who were diagnosed between the ages of 30-39 were more likely to die. NHB had an adjusted HR of 3 (95% CI 2.7, 3.3) compared to NHW. The adjusted HR of lower limb was 1.6 (95% CI 1.5, 1,6) compared to the reference group (Head and Neck). The hazard for trunk and lower limb were about the same as the reference. Those who were 70 years or older had an adjusted HR of 2.2 (95% CI 2.0, 2.4). Women had an adjusted HR of 0.4 (95% CI 0.4, 0.5), and diagnosis during the decade 1982-1991 had an adjusted HR of 2.6 (95% CI 2.4, 2.7).Conclusions: NHB patients and patients of ages 30-39 years were more likely to die. The poorest survival was for diagnosis between 1982 and 1991. However, more individuals were diagnosed between 2002 and 2011. The lower limb had a worse prognosis with adjusted HR of 1.6 (95% CI 1.5, 1,6), and more men were diagnosed than women.

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“…A recent study from the Sydney Melanoma Unit showed that up to 30% of patients with lymph node metastases from neck melanomas bypass the nearest node and involve nodes at more distant sites (Pathak et al 2001), so called "skip metastases". Numerous studies have evaluated the survival differences between head and neck melanoma versus those of the trunk and extremities and have found that those with melanoma of the head and neck have relatively poorer outcome (Gillgren et al 2000;Lachiewicz et al 2008;Thorn et al 1989). Specifically in a study involving 51,704 patients with melanoma, 5-and 10-year KaplanMeier survival probabilities for scalp/neck melanoma were 83.1% and 76.2%, respectively, compared with 92.1% and 88.7%, respectively, for melanoma of the other sites, including extremities, trunk, face, and ears.…”

Section: Impact Of Histological Site On Outcomementioning

confidence: 99%

Impact of Sentinel Node Biopsy on Outcome in Melanoma

Kelly¹,

Kerin²

2011

Treatment of Metastatic Melanoma

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The association between anatomic site and survival in malignant melanoma. An analysis of 12,353 cases from the Swedish cancer registry

Cited by 73 publications

References 21 publications

Survival Differences Between Patients With Scalp or Neck Melanoma and Those With Melanoma of Other Sites in the Surveillance, Epidemiology, and End Results (SEER) Program

Survival Differences Between Patients With Scalp or Neck Melanoma and Those With Melanoma of Other Sites in the Surveillance, Epidemiology, and End Results (SEER) Program

Differences in survival by race/ethnicity among cutaneous melanoma patients in the United States over a period from 1982 to 2011

Impact of Sentinel Node Biopsy on Outcome in Melanoma

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