The Association Between ABO Blood Group and Preeclampsia: A Systematic Review and Meta-Analysis

Abstract

Objective: This meta-analysis comprehensively evaluated the association between ABO blood group and the risk of preeclampsia (PE).Design: Systematic review and meta-analysis.Data sources: PubMed, Web of Science, and ScienceDirect databases from their inception to September 23, 2020.Methods: Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were obtained through random-effects and fixed-effects models according to heterogeneity. Meta-regression analysis was applied to explore the source of heterogeneity. We conducted a subgroup analysis by the publication year, study design, state, and Newcastle-Ottawa Scale (NOS) score. In addition, we calculated the rate of each ABO blood group in PE by total pooled effects.Results: A total of 12 articles with 714,153 patients were included in our analysis. Compared with people without PE (control group), the O blood group presented a lower risk of PE (OR 0.95, 95% CI 0.93–0.97). The AB (OR 1.46, 95% CI 1.12–1.91) blood group presented a higher risk. However, the total pooled OR and 95% CI for the A (OR 1.02, 95% CI 0.90–1.16) and B (OR 1.02, 95% CI 0.98–1.05) blood groups were not significant. The funnel plot and linear regression equation showed that there was no publication bias for the O, A, or B blood groups (all P > 0.05). However, the funnel plot and linear regression equation for the AB blood group were obviously asymmetric (P < 0.05), and the publication bias persisted even after the trim-and-fill method was applied (P < 0.05). Multivariable meta-regression analysis did not find a specific source of heterogeneity. The A blood group showed an association with early-onset PE (OR 0.53, 95% CI 0.33–0.83), and the other blood groups showed no significant differences. In PE, the rates of the O, A, B, and AB blood groups decreased gradually (0.39, 0.33, 0.19, 0.07).Conclusion: These findings suggest that pregnant women with AB blood group are more likely to develop PE, and more attention should be paid to AB blood group whose blood pressure is high but not sufficient to diagnose PE.Systematic Review Registration: Prospero CRD42021227930.

Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

“…14,40,49,53 Several previous systematic reviews and meta-analyses have also shown that individuals with blood type O are at lower risk of infection, including with SARS-CoV-2, 45,54 and preeclampsia. 43 In contrast, other studies have shown that individuals with blood type O are more likely to develop T2DM 22 and gestational diabetes, 44 Plasmodium falciparum infection, 55 and tuberculosis infection. 56,57…”

“…14,40,49,53 Several previous systematic reviews and meta-analyses have also shown that individuals with blood type O are at lower risk of infection, including with Overall (I-squared = 0.0%, p = 0.520) SARS-CoV-2, 45,54 and preeclampsia. 43 In contrast, other studies have shown that individuals with blood type O are more likely to develop T2DM 22 and gestational diabetes, 44 Plasmodium falciparum infection, 55 and tuberculosis infection. 56,57 The mechanisms underlying the observed associations have been suggested to involve endothelial and pro-inflammatory molecules, and the factor VIII-von Willebrand factor complex, plasma soluble intercellular adhesion molecule 1 (ICAM-1), and tumor necrosis factor receptor 2 (TNF-R2) concentrations are higher in individuals with blood groups other than O.…”

“…Antigens of the ABO blood group are found on a variety of human cells, including vascular endothelial cells and brain cells, in addition to red blood cells. 1 Links between blood group and a wide range of diseases, including obesity, 42 preeclampsia, 43 gestational diabetes, 44 gastric cancer, and cardiovascular disorders have been identified. 1 In addition, ABO blood group-related susceptibility to various viral infections, including with hepatitis B, influenza viruses, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been shown in several studies.…”

Genetic variation in placental insufficiency: What have we learned over time?

“…The HLA genes are the most polymorphic system of genes in the human genome, and they are primarily relevant to immune function and transplantation (Bjorkman et al, 1987). Other common protein variants historically used in genetic association studies were the ABO blood groups, G6PD, and HPRT1 (Longo et al, 2002;Li et al, 2021).…”

Indicators of Cardiometabolic Function in Pregnancy and Long-Term Risk of COVID-19: Population-Based Cohort Study

“…Births and outpatient and inpatient encounters were captured in province-wide administrative datasets that were linked using unique encoded identifiers and analyzed at ICES (https://datadictionary.ices.on.ca/Applications/DataDictionary/Default.aspx), as described by Catov et al and Li et at. [1,5] and in Appendix table. BMI was identified in the Better Outcomes Registry and Network (BORN) Information System and Niday Perinatal Databases with a 50-g GCT in the Ontario Laboratory Information System [6].…”