The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy

Qi, Yanxin; Jing, Shi-Wei; He, Shasha; Xiong, Hejian; Yang, Guang; Huang, Yubin; Jin, Ningyi

doi:10.1007/s12274-020-3113-1

Cited by 5 publications

(1 citation statement)

References 39 publications

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“…Importantly, a novel multifunctional drug–Ru complex conjugate, [Ru(DCAtpy)(biq)(Cl)], was coordinated to the amphiphilic block copolymer via photodegradable Ru–N coordination bond. In the conjugate, dichloroacetate acid (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK), which has great promise to realize much more efficient metabolic alterations and improved PDT outcomes. − Red light induced the cleavage of the drug–Ru complex conjugates from MPEG- b -PMCC, which was accompanied by the generation of 1 O 2 , resulting in enhanced therapeutic effects (Figure a). This polymer with direct coordination and photoactivation strategy is more advantageous than the Ru-containing polymer which released Ru complexes and anticancer drugs separately, because the drug was released in this system through breaking the ROS-sensitive linker, which consumed a certain amount of 1 O 2 and reduced the PDT effect .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement

Wang

Wan

et al. 2022

Biomacromolecules

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The lack of selectivity between tumor and healthy cells, along with inefficient reactive oxygen species production in solid tumors, are two major impediments to the development of anticancer Ru complexes. The development of photoinduced combination therapy based on biodegradable polymers that can be light activated in the “therapeutic window” would be beneficial for enhancing the therapeutic efficacy of Ru complexes. Herein, a biodegradable Ru-containing polymer (poly(DCARu)) is developed, in which two different therapeutics (the drug and the Ru complex) are rationally integrated and then conjugated to a diblock copolymer (MPEG-b-PMCC) containing hydrophilic poly(ethylene glycol) and cyano-functionalized polycarbonate with good degradability and biocompatibility. The polymer self-assembles into micelles with high drug loading capacity, which can be efficiently internalized into tumor cells. Red light induces the generation of singlet oxygen and the release of anticancer drug–Ru complex conjugates from poly(DCARu) micelles, hence inhibiting tumor cell growth. Furthermore, the phototherapy of polymer micelles demonstrates remarkable inhibition of tumor growth in vivo. Meanwhile, polymer micelles exhibit good biocompatibility with blood and healthy tissues, which opens up opportunities for multitherapeutic agent delivery and enhanced phototherapy.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement

Wang

Wan

et al. 2022

Biomacromolecules

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Human Serum Albumin‐Coated ¹⁰B Enriched Carbon Dots as Targeted “Pilot Light” for Boron Neutron Capture Therapy

Zhong,

Yang,

Pang

et al. 2024

Advanced Science

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Boron neutron capture therapy (BNCT) is a physiologically focused radiation therapy that relies on nuclear capture and fission processes. BNCT is regarded as one of the most promising treatments due to its excellent accuracy, short duration of therapy, and low side effects. The creation of novel boron medicines with high selectivity, ease of delivery, and high boron‐effective load is a current research topic. Herein, boron‐containing carbon dots (BCDs) and their human serum albumin (HSA) complexes (BCDs‐HSA) are designed and synthesized as boron‐containing drugs for BNCT. BCDs (10B: 7.1 wt%) and BCDs‐HSA exhibited excitation‐independent orange fluorescent emission which supported the use of fluorescence imaging for tracking 10B in vivo. The introduction of HSA enabled BCDs‐HSA to exhibit good biocompatibility and increased tumor accumulation. The active and passive targeting abilities of BCDs‐HSA are explored in detail. Subcutaneous RM‐1 tumors and B16‐F10 tumors both significantly decrease with BNCT, which consists of injecting BCDs‐HSA and then irradiating the area with neutrons. In short, this study provides a novel strategy for the delivery of boron and may broaden the perspectives for the design of boron‐containing carbon dots nanomedicine for BNCT.

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Nanotechnology-based combinational strategies toward the regulation of myofibroblasts and diseased microenvironment in liver fibrosis and hepatic carcinoma

Zhao

Nie

2023

Nano Res.

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The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy

Cited by 5 publications

References 39 publications

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement

Human Serum Albumin‐Coated ¹⁰B Enriched Carbon Dots as Targeted “Pilot Light” for Boron Neutron Capture Therapy

Nanotechnology-based combinational strategies toward the regulation of myofibroblasts and diseased microenvironment in liver fibrosis and hepatic carcinoma

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The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy

Cited by 5 publications

References 39 publications

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement

Human Serum Albumin‐Coated 10B Enriched Carbon Dots as Targeted “Pilot Light” for Boron Neutron Capture Therapy

Nanotechnology-based combinational strategies toward the regulation of myofibroblasts and diseased microenvironment in liver fibrosis and hepatic carcinoma

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Product

Resources

About

Human Serum Albumin‐Coated ¹⁰B Enriched Carbon Dots as Targeted “Pilot Light” for Boron Neutron Capture Therapy