The assessment of testosterone and radioisotopic index of bone metabolism and bone mineral density in men with testosterone deficiency after one year of testosterone therapy

Tryniszewski, Wiesław; Kamiński, Grzegorz; Maziarz, Zbigniew; Nowak, Michał S.; Gadzicki, Mariusz; Radek, Maciej

doi:10.5603/nmr.a2018.0002

Cited by 4 publications

(4 citation statements)

References 10 publications

(10 reference statements)

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“…Anabolic steroids (AS), including testosterone [1] are hormones that are usually used in a therapeutic setting [2–4]. However, they have also been illicitly employed as performance enhancers by professional competitors, school and amateur athletes [5], as well as by college students seeking improved Esthetics [5,6].…”

Section: Introductionmentioning

confidence: 99%

Anabolic steroids among resistance training practitioners

et al. 2019

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ObjectiveTo compare the use of anabolic steroids (AS), the motivation to use them, their side effects, the source of information and the form in which AS were obtained, the medical follow-up, and the periodic examinations in resistance training practitioners who are either current or former users of AS.MethodsA prevalence survey was performed in the gyms of the city of Curitiba, including 719 current and former AS users who self-administered a questionnaire. The chi-square and z of proportions (p <0.05) statistical tests were conducted.ResultsEsthetics was the main motivation associated with AS intake, leading to satisfactory results. The information about the form in which to use AS was provided by doctors and AS were either purchased at the pharmacy with a prescription or illegally. Current users reported a higher number of cycles and doses, a longer duration of use, as well as larger economical investments into AS. This shows a higher consumption of such drugs, regardless of the medical follow-up and post-cycle therapy.ConclusionGiven that a change in the usage pattern was observed when increasing the AS consumption, this should be considered in the elaboration of public policies to inhibit such a trend.

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Section: Introductionmentioning

confidence: 99%

Anabolic steroids among resistance training practitioners

et al. 2019

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“… 10 Xia Jin-wei et al founded that the ratio of E2/ testosterone of the type 2 diabetes group was significantly increased, whereas testosterone was obviously decreased compared with healthy people. 18 Testosterone replacement therapy (TRT) in men has been found to increase BMD and decrease osteoporosis/osteopenia, 31 , 32 but some studies showed TRT has limited effect on increasing BMD, 33 it needs more research to confirm the effect of TRT on bone health in male. As for women, several studies have reported the important role of testosterone in BMD or osteoporosis, 34 while others showed that testosterone was not associated with BMD, 35 and that spin and hip BMD losses during the menopause transition was not related to androgen.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 Diabetes Mellitus

Lü¹,

Zheng²,

Zhou³

et al. 2023

DMSO

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Objective This study aimed to examine associations between plasma sex-related hormones with bone mineral density (BMD) and risks of osteoporosis or osteopenia in men and postmenopausal women patients with type 2 diabetes mellitus (T2DM). Methods Baseline information on an ongoing cohort of 149 men and 102 postmenopausal women with T2DM in Xiamen, China were analyzed. Plasma estradiol (E2), total testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) were measured. BMD of lumbar spine (L2-4), femoral neck (FN) and total hip (TH) were determined by dual-energy X-ray absorptiometry (DXA). Osteoporosis or osteopenia was defined as the minimum T-scores of BMD of these three different sites of −1.0 or below. Results T2DM patients with osteoporosis/osteopenia (66.4% in men and 79.4% in postmenopausal women), compared to those without, showed significantly decreased level of E2 (75.3±28.9 vs. 107.8±25.9pmol/L and 18.4 (18.4–29.5) vs. 22.8 (18.4–40.5) pmol/L for men and postmenopausal women, respectively, both p-values <0.05), but not other sex-related hormones (including T, FSH, LH, or PRL). For all T2DM patients together and men separately, multivariable linear regression and logistic regression analyses showed that higher E2 levels were significantly associated with higher BMD T-scores in L2-4, FN, TH and minimum of these three different sites, lower 10-year probability of major osteoporotic fractures (MOF) and hip fractures (HFs) estimated by Fracture Risk Assessment Tool score, as well as decreased risk of osteoporosis/osteopenia. As for postmenopausal women T2DM patients, E2 level was positively associated with BMD T-scores in L2-4 and minimum of three different sites but was not independently associated with risk of osteoporosis/osteopenia. Conclusion Higher plasma E2 was significantly associated with increased BMD and lower risk of osteoporosis or osteopenia in T2DM patients, especially for men. Screening of BMD and estradiol levels as well as evaluating risks of osteoporosis/osteopenia are important for T2DM patients.

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“…The measurement results were expressed by T value. T= (BMD value - bone peak value of healthy people of the same gender)/standard deviation of bone peak value of healthy people of the same gender [ 6 ]. According to the T value, the selected cases were further grouped as the control group (no OS) with 43 cases and observation group (with T value <-2.5, which could be diagnosed as OS) with 45 cases.…”

Section: Methodsmentioning

confidence: 99%

Bone metabolism factors in predicting the risk of osteoporosis fracture in the elderly

Zhang,

Hu,

Cai

2024

BMC Musculoskelet Disord

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Objective Osteoporosis (OS) is a systemic bone disease characterized by low bone mass and bone microstructure damage. This study. Methods According to the T value, 88 elderly fracture patients were grouped as the control group (without OS, 43 cases) and observation group (with T value <-2.5, which could be diagnosed as OS, 45 cases). The content of boney containing protein (BGP), total type 1 collagen amino terminal extender peptide (TPINP), β-Crosslaps (β-CTX), parathyroid hormone (PTH) and insulin-like growth factors-1 (IGF-1) was compared. Multivariate logistic regression was adopted to analyze the correlation between biochemical indexes and the occurrence of senile OS fracture and the related risk factors. The diagnostic value in the elderly was analyzed by receiver operating characteristic (ROC) curve. Results The levels of BGP, TPINP, β-CTX, PTH and IGF-1 were elevated, and the level of IGF-1 was decreased in the observation group compared with the control group (P < 0.05). The elevated content of BGP, TPINP, β-CTX and PTH, and the decreased expression of IGF-1 were influencing factors for OS fractures in the elderly (P < 0.05). The sensitivity and specificity to predict the occurrence of OS fractures in the elderly were 91.70% and 90.50%, respectively. The AUC of combined detection was 0.976 (95% CI: 0.952-1.000), which was memorably higher than single indicator detection (P < 0.05). Among 45 patients, 32 cases had good prognosis and 13 had poor prognosis. In comparison with the good prognosis group, the content of BGP, TPINP, β-CTX and PTH were sensibly higher, the level of IGF-1 was prominently lower, and the proportion of fracture history was much higher in poor prognosis group (P < 0.05). Fracture history, BGP, TPINP, β-CTX, PTH and IGF-1 were independent risk factors for poor prognosis of elderly OS fractures (P < 0.05). Conclusion Bone metabolism factors were associated with poor prognosis of OS in the elderly. The combined detection had higher diagnostic value in calculating the risk of OS fracture in the elderly than single indicator detection.

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The assessment of testosterone and radioisotopic index of bone metabolism and bone mineral density in men with testosterone deficiency after one year of testosterone therapy

Abstract: BACKGROUND:Testosterone deficiency in men is characterized by typical symptoms of hypogonadism and negative influence on the preservation of bone mass. In this study, we analysed the relationship between testosterone concentration and

Cited by 4 publications

References 10 publications

Anabolic steroids among resistance training practitioners

Anabolic steroids among resistance training practitioners

Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 Diabetes Mellitus

Bone metabolism factors in predicting the risk of osteoporosis fracture in the elderly

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