“…Moreover, precise quantitative measurement of fetal organ dimensions becomes possible when the 3-D volume is retrieved (Chang et al 1997a;Merz et al 1995). Since our first report of primary application of 3-D US in obstetrics (Kuo et al 1992), we have published a series of fetal organ volume assessments using 3-D US, including fetal liver, heart, cerebellum, renal, adrenal gland, lung and brain volume from early second trimester to third trimester and obtained more accurate results (Chang et al 1997a(Chang et al , 1997b(Chang et al , 1997cChang et al 2000aChang et al , 2000bChang et al , 2002aChang et al , 2002bChang et al , 2003bChang et al , 2003cChang et al , 2003dLiang et al 1997;Yu et al 2000). From this prospective study of fetal ThVol assessment in detecting IUGR, as well as our previous study of ThVol centiles in normal gestation (Chang et al 2003a), we further proved that ThVol can be measured by 3-D US with adequate precision and reproducibility.…”