The assessment of consistency using penetrometer and apparent diffusion coefficient (ADC) value using diffusion weighted magnetic resonance imaging (DW-MRI) from polyvinyl alcohol (PVA) formed by freezing-thawing cycle

Dwihapsari, Yanurita; Sari, Dita Puspita; Darminto, Darminto

doi:10.1063/1.4730686

Cited by 4 publications

(5 citation statements)

References 1 publication

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“…The result from ADC measurement using different bvalue in DW-MRI for PVA hydrogel samples with different concentration and number of freezing-thawing cycle are described in Figure 3 and with our hypothesis of higher diffusion coefficient with lower concentration and lower number of freezing and thawing [10,15]. In Figure 4, it is showed that the linearity of the ADC value graph at b-value 3000 s/mm 2 is better than ADC graph at b-value 1000 s/mm 2 which is in line with the sample parameter that we used.…”

Section: Resultssupporting

confidence: 67%

“…It has been described by the illustration in Figure 1 that the structure of PVA cryogels, which is a PVA hydrogels obtained by freezing-thawing (F-T) technique, consists in three phases; a water phase, amorphous phase and a crystalline phase [8]. According to recent experiment, increasing number of freezing-thawing cycles would increase the crystallite, the degree of physical crosslinking and rigidity of hydrogel, decrease water diffusion coefficient which is ADC in this research [9,10].…”

Section: Introductionmentioning

confidence: 66%

“…ADC value was calculated by Functool software (GE Medical Systems) and obtained by calculating Signal Intensity (SI) on DWI after placing seven uniform region of interest (ROI)s in each sample. According to a recent experiment result [10], ADC value were calculated by averaging ADC values from several ROIs for each sample.…”

Section: Adc Measurement Using Dw-mrimentioning

confidence: 99%

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Measurement of Hydrogen Diffusion through PVA Hydrogel using Magnetic Resonance Imaging Method in Comparison with Consistency Assessment using Digital Penetrometer

Sari

Darminto

2015

JFA

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A study of hydrogen diffusion behavior in the PVA (polyvinyl-alcohol) hydrogel had been done to measure diffusion coefficient (Apparent Diffusion Coefficient/ ADC) used as parameter of brain tumor grading. For our study, PVA hydrogel samples were prepared using freezing-thawing method with various concentration and number of freezing-thawing cycles. The ambiguity of brain tumor grading using ADC value, which is formed from Diffusion Weighted-Imaging 1,5 T, could be reduced enough with observing the result of correlation the ADC at b-value 1000 s/mm 2 and 3000 s/mm 2 with assessment of consistency measured using digital penetrometer based on microcontroller.

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Section: Resultssupporting

confidence: 67%

Section: Introductionmentioning

confidence: 66%

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Measurement of Hydrogen Diffusion through PVA Hydrogel using Magnetic Resonance Imaging Method in Comparison with Consistency Assessment using Digital Penetrometer

Sari

Darminto

2015

JFA

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“…PVA gel, gadolinium (Gd) contrast agent 10 cm 3 10% PVA cryogel solution containing sufficient Gd for good contrast on T2W-MRI was cast into a cylindrical mould and a freeze-thaw cycle repeated five times to produce a degree of contrast with the bladder wall to aid visibility on ADC maps. 21…”

Section: Tumourmentioning

confidence: 99%

Quantification and correction of distortion in diffusion-weighted MRI at 1.5 and 3 T in a muscle-invasive bladder cancer phantom for radiotherapy planning

Rogers

Sherwood

Wayte

et al. 2020

The British Journal of Radiology

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Objective: Limited visibility of post-resection muscle-invasive bladder cancer (MIBC) on CT hinders radiotherapy dose escalation of the residual tumour. Diffusion-weighted magnetic resonance imaging (DW-MRI) visualizes areas of high tumour burden and is increasingly used within diagnosis and as a biomarker for cancer. DW-MRI could, therefore, facilitate dose escalation, potentially via dose-painting and/or accommodating response. However, the distortion inherent in DW-MRI could limit geometric accuracy. Therefore, this study aims to quantify DW-MRI distortion via imaging of a bladder phantom. Methods: A phantom was designed to mimic MIBC and imaged using CT, DW-MRI and T2-weighted (T2w) MRI. Fiducial marker locations were compared across modalities and publicly-available software was assessed for correction of magnetic susceptibility-related distortion. Results: Fiducial marker locations on CT and T2w-MRI agreed within 1.2 mm at 3 T and 1.8 mm at 1.5 T. The greatest discrepancy between CT and Apparent Diffusion Coefficient (ADC) maps was 6.3 mm at 3 T, reducing to 1.8 mm when corrected for distortion. At 1.5 T these values were 3.9 mm and 1.7 mm respectively. Conclusions: Geometric distortion in DW-MRI of a model bladder was initially >6 mm at 3 T and >3 mm at 1.5 T, however, established correction methods reduced this to <2 mm in both cases. Advances in knowledge: A phantom designed to mimic MIBC has been produced and used to show distortion in DW-MRI can be sufficiently mitigated for incorporation into the radiotherapy pathway. Further investigation is therefore warranted to enable individually-adaptive image-guided radiotherapy of MIBC based upon DW-MRI.

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“…ADC value was calculated by Functool software (GE Medical Systems) and obtained by calculating Signal Intensity (SI) on DWI after placing seven uniform region of interest (ROI)s in each sample. According to a recent experiment result [16], ADC value was calculated by averaging ADC values from several ROIs for each sample.…”

Section: B Adc Measurement Using Dw-mrimentioning

confidence: 99%

Brain tumor consistency assessment using digital penetrometer and Diffusion Weighted MRI

Sari¹,

Kristanto²,

Wahyudi³

et al. 2013

2013 3rd International Conference on Instrumentation, Communications, Information Technology and Biomedical Engineering (ICICI-

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A study of hydrogen diffusion behavior in the PVA hydrogel had been done to measure diffusion coefficient (ADC) from tissue mimicking. For our study, PVA hydrogel samples were prepared using freezing-thawing method with various concentration and number of freezing-thawing cycles. Consistency measurement with physical mechanism had been done to the samples by digital penetrometer. We measured ADC value of the hydrogel PVA with Diffusion Weighted Magnetic Resonance Imaging 1.5 T in the way we measured ADC value of the abnormal tissue from several cases of human Brain Tumor. With high correlation of the consistency data and ADC value, we can assess the human Brain Tumor consistency.

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The assessment of consistency using penetrometer and apparent diffusion coefficient (ADC) value using diffusion weighted magnetic resonance imaging (DW-MRI) from polyvinyl alcohol (PVA) formed by freezing-thawing cycle

Cited by 4 publications

References 1 publication

Measurement of Hydrogen Diffusion through PVA Hydrogel using Magnetic Resonance Imaging Method in Comparison with Consistency Assessment using Digital Penetrometer

Measurement of Hydrogen Diffusion through PVA Hydrogel using Magnetic Resonance Imaging Method in Comparison with Consistency Assessment using Digital Penetrometer

Quantification and correction of distortion in diffusion-weighted MRI at 1.5 and 3 T in a muscle-invasive bladder cancer phantom for radiotherapy planning

Brain tumor consistency assessment using digital penetrometer and Diffusion Weighted MRI

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