The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects

Abstract

BackgroundThe role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori) infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C) has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1) is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects.MethodsThirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries.ResultsWe found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014). We found that PON1 activities were significantly lower in H. pylori positive subjects compared with negative subjects. No significantly correlation was observed between PON1 and CIMT values.ConclusionsThere is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms.

Gastric Helicobacter pylori infection is associated with adverse metabolic traits in severely obese subjects

“…In accordance with a foregoing study (13), we observed an association of Hp infection with increased TG levels. Furthermore, Hp infection was found to be associated with a higher total chloesterol‐to‐HDL ratio.…”

Leptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low‐Density Lipoprotein and Decreased High‐Density Lipoprotein

“…Serum PON1 activity has been shown to be low in several infections such as hepatitis C [29], HIV [30] and helicobacter pylori [31,32], primarily because of changes in synthesis and/or secretion of HDL and apoA-I particles. The activities of both PON1 (paraoxonase) and PON1 (arylesterase) were lower in patients 4 months after recovery compared with controls.…”

Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

“…Fortunately, some studies have limitedly investigated the association between CIMT and H. pylori infection (10) . For example, Akbas and colleagues reported that the CIMT among positive H. pylori subjects was significantly higher than that in those with negative H. pylori infection (1) . Findings of this study were in accordance with the results of Akbas et al Of course, our study was relatively different from Akbas study, so this study compared chronic gastric patients either with or without H. pylori infection with the healthy subjects.…”