The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery

Abstract

Nanocarriers are widely used for delivering drugs to tumors and are progressing in a stable trend, because malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. Furthermore, as an integrated platform, nanocarriers have the potential to dramatically improve cancer diagnosis, imaging, and therapy, while reducing the toxicity associated with the current approaches. Significantly, intelligent nanocarriers are the new generation of the nanocarriers, exhibiting superior tumor targeting and improved therapeutic efficacy. In this review, we discuss recent development in the design of nanoscale stimuli-responsive systems which will be able to control drug biodistribution in response to specific stimuli, either exogenous or endogenous. Meanwhile, the recent progress in engineering intelligent and versatile nanomaterials for targeting the tumor microenvironment is summarized.

Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

“…However, the application of these stimuli-responsive drug delivery systems is limited by many restrictions and technical impediments yet to be settled. For enzyme-responsive drug delivery systems, the understanding of quantitative changes in enzyme content at the lesion sites of the joint is poor, though they are elementary in regulating drug release and cell uptake in vivo [ 20 ]. Only by entirely understanding the mathematical changes of the enzymes in the lesion site can the drug release be extremely restrained and accurately mediated.…”

“…The conveyance can be assembled in different architecture and applied to trigger accurate and timely drug release, ensuring great flexibility of stimuli-responsive material systems. Eventually, this would improve the therapeutic efficacy of arthritis [ 20 ].…”

RETRACTED: Stimulus-responsive tea polyphenols as nanocarrier for selective intracellular drug delivery

“…8,9 Tumor pathological environment stimuli, such as specific ions, temperature, proteins, enzymes, acidity, and redox conditions, -responsive nanodrug delivery systems have attracted great attention in tumor chemotherapy. [10][11][12] Among these stimulus, low pH and high level of glutathione (GSH) in the tumor tissue and cells have been widely researched. The pH values of different tissues in vivo are quite different.…”

Brain-Targeted Polysorbate 80-Emulsified Donepezil Drug-Loaded Nanoparticles for Neuroprotection

“…Loading other drugs with high fat solubility and poor dissolution in vivo into the hydrophobic center of the NPs can not only increase brain targeting but also improve the water solubility of the drug. In addition, the design of CHP nanoparticle solutions is simple, and the drug dosage of the hydrophobic center can be flexibly controlled to ensure the best therapeutic effect while minimizing cytotoxicity [ 48 , 49 ]. In future work, we will conduct in vivo research on DZP-CHP nanoparticles, such as evaluation of drug metabolism and side effects.…”