Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

Zhang, Mi; Hu, Wenhui; Cai, Chenhui; Wu, Yu; Li, Jianmei; Dong, Shiwu

doi:10.1016/j.mtbio.2022.100223

Cited by 150 publications

(132 citation statements)

References 154 publications

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“…In vivo administration of anti-arthritic agents faces several limitations, such as rapid loss, nonspeci c exposure, and off-target effects [35]. Generally, systemic injection of drugs, such as the intraperitoneal method, exerts broad-spectrum therapeutic effects on the whole body [36]; however, articular cartilage is free of blood and oxygen supply, and so systemic drug delivery shows little success [37].…”

Section: Discussionmentioning

confidence: 99%

Arbutin-Modified Microspheres Prevent Osteoarthritis Progression by Mobilizing Local Anti-Inflammatory and Antioxidant Responses

Jin

Liu

Jiang

et al. 2022

Preprint

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Osteoarthritis (OA), a common chronic degenerative disease, is considered the leading cause of disability worldwide. However, the current clinical treatments for OA are still unsatisfactory. Arbutin (ARB) is a major active ingredient of the Chinese medicinal herb cowberry leaf, which exerts potential antioxidant and anti-inflammatory activity. Based on a microfluid platform, we fabricated ARB-loaded gelatine methacryloyl-Liposome (GM-Lipo@ARB) microspheres that showed long-term release and excellent cartilage-targeting effects. The ARB-loaded microspheres effectively reduced the inflammatory response in interleukin (IL)-1β-treated arthritic chondrocytes. Moreover, GM-Lipo@ARB microspheres regulated cartilage extracellular matrix (ECM) homeostasis by upregulating nuclear factor erythroid 2-related factor 2 (Nrf2)-associated antioxidant properties. Intraarticular injection of GM-Lipo@ARB microspheres alleviated cartilage erosion in the destabilization of the medial meniscus (DMM)-mediated mouse OA model. Our results indicated that ARB-modified microspheres prevented cartilage degeneration by not only inhibiting the inflammatory reaction but also mitigating oxidative stress. This study proposes a novel ARB-laden functional microsphere for treating OA through the mobilization of local anti-inflammatory and antioxidant responses.

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Section: Discussionmentioning

confidence: 99%

Arbutin-Modified Microspheres Prevent Osteoarthritis Progression by Mobilizing Local Anti-Inflammatory and Antioxidant Responses

Jin

Liu

Jiang

et al. 2022

Preprint

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“…With the proposed concept of “microenvironment”, the focus on targeted and sustained therapeutic agents has gradually shifted to stimulate drug release in recent decades ( Mura et al, 2013 ; Baek et al, 2015 ). To accommodate weak acidity, abnormal enzyme and redox levels, and localized heat and swelling in the pathologically altered bone microenvironment, more precise and sensitive response components are needed to achieve on-demand, targeted drug release, thereby minimizing the possibility of an abrupt or premature drug release and reducing the likelihood of adverse effects ( Lavrador et al, 2018 ; Hopkins and Qin, 2020 ; Zhang et al, 2022 ). Scientists have developed some novel local targeting systems over the past years, i.e.…”

Section: Bone-targeted Strategiesmentioning

confidence: 99%

Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease

Chen

et al. 2022

Front. Pharmacol.

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Targeted delivery by either systemic or local targeting of therapeutics to the bone is an attractive treatment for various bone metabolism diseases such as osteoporosis, osteoarthritis, osteosarcoma, osteomyelitis, etc. To overcome the limitations of direct drug delivery, the combination of bone-targeted agents with nanotechnology has the opportunity to provide a more effective therapeutic approach, where engineered nanoparticles cause the drug to accumulate in the bone, thereby improving efficacy and minimizing side effects. Here, we summarize the current advances in systemic or local bone-targeting approaches and nanosystem applications in bone diseases, which may provide new insights into nanocarrier-delivered drugs for the targeted treatment of bone diseases. We envision that novel drug delivery carriers developed based on nanotechnology will be a potential vehicle for the treatment of currently incurable bone diseases and are expected to be translated into clinical applications.

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“…Targeted drug delivery is an important feature of IONPs ( Figure 9 ), and IONPs complexes are commonly used as carriers for controlled drug release ( Prodan et al, 2013 ). For instance, IONPs have been found to stimulate the corresponding drug delivery systems for targeted drug delivery in arthritis ( Zhang et al, 2022 ). To enhance the anti-osteoporosis effect, the investigators synergized IONPs with alendronate, and the combination substantially improved bone mineral density and microarchitecture compared to the same dose of alendronate ( Zheng et al, 2022 ).…”

Section: Application Of Iron Oxide Nanoparticles In Bone Regenerationmentioning

confidence: 99%

“…Several studies have demonstrated that IONPs can positively regulate bone metabolism in vitro and in vivo , and that they have favorable bone targeting, bone regeneration and biocompatibility properties. For instance, Zheng et al (2022) revealed that IONPs can alleviate osteoporosis induced by ovariectomized mice (OVX) by scavenging reactive oxygen species, promoting osteogenic differentiation of BMSCs and inhibiting osteoclastogenesis in vitro . Krzysztof et al ( Marycz et al, 2022 ) combined aminopropyltriethoxysilane (APTES) modified nHAp with IO nanoparticles and demonstrated in vitro that this biomaterial promotes osteoblast viability and RUNX-2 expression, reduces osteoclast metabolism and inflammation, and can be used for healing of osteoporotic fractures.…”

Section: Application Of Iron Oxide Nanoparticles In Pathological Bone...mentioning

confidence: 99%

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Wang

Xie

et al. 2022

Front. Bioeng. Biotechnol.

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Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable them to play an active role in bone regeneration. This paper reviews the application of IONPs in bone tissue regeneration in recent years, and outlines the mechanisms of IONPs in bone tissue regeneration in detail based on the physicochemical properties, structural characteristics and safety of IONPs. In addition, a bibliometric approach has been used to analyze the hot spots and trends in the field in order to identify future directions. The results demonstrate that IONPs are increasingly being investigated in bone regeneration, from the initial use as magnetic resonance imaging (MRI) contrast agents to later drug delivery vehicles, cell labeling, and now in combination with stem cells (SCs) composite scaffolds. In conclusion, based on the current research and development trends, it is more inclined to be used in bone tissue engineering, scaffolds, and composite scaffolds.

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Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

Cited by 150 publications

References 154 publications

Arbutin-Modified Microspheres Prevent Osteoarthritis Progression by Mobilizing Local Anti-Inflammatory and Antioxidant Responses

Arbutin-Modified Microspheres Prevent Osteoarthritis Progression by Mobilizing Local Anti-Inflammatory and Antioxidant Responses

Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease

Hope for bone regeneration: The versatility of iron oxide nanoparticles

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