The Application of Nanotechnology to Drug Delivery in Medicine

McDonald, Tom O.; Siccardi, Marco; Moss, Darren M.; Liptrott, Neill J.; Giardiello, Marco; Rannard, Steve P.; Owen, Andrew

doi:10.1016/b978-0-444-62747-6.00007-5

Cited by 17 publications

(9 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that tumoral tissues have capillaries and blood vessels with larger pores, ranging from 100 to several hundred nanometers, compared with healthy tissues. So, NPs with sizes ranging from 100 to 500 nm, as the GNPs developed in the present work, can easily penetrate the tumor mass, in contrast with healthy tissues, characterized by an intact vasculature [43].…”

Section: Discussionmentioning

confidence: 90%

Preliminary Assays towards Melanoma Cells Using Phototherapy with Gold-Based Nanomaterials

et al. 2020

View full text Add to dashboard Cite

Cancer like melanoma is a complex disease, for which standard therapies have significant adverse side effects that in most cases are ineffective and highly unspecific. Thus, a new paradigm has come with the need of achieving alternative (less invasive) and effective therapies. In this work, biocompatible gold nanoparticles (GNPs) coated with hyaluronic acid and oleic acid were prepared and characterized in terms of size, morphology and cytotoxicity in the presence of Saccharomyces cerevisiae, and two cell lines, the keratinocytes (healthy skin cells, HaCat) and the melanoma cells (B16F10). Results showed that these GNPs absorb within the near-infrared region (750–1400 nm), in the optical therapeutic window (from 650 to 1300 nm), in contrast to other commercial gold nanoparticles, which enables light to penetrate into deep skin layers. A laser emitting in this region was applied and its effect also analyzed. The coated GNPs showed a spherical morphology with a mean size of 297 nm without cytotoxic effects towards yeast and tested cell lines. Nevertheless, after laser irradiation, a reduction of 20% in B16F10 cell line viability was observed. In summary, this work appears to be a promising strategy for the treatment of non-metastatic melanoma or other superficial tumors.

show abstract

Section: Discussionmentioning

confidence: 90%

Preliminary Assays towards Melanoma Cells Using Phototherapy with Gold-Based Nanomaterials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Solid drug nanoparticles are the simplest form of nanomedicine, often referred to as nanosuspensions or nanodispersions. (Rabinow, ; McDonald et al, ) The NP is composed of the drug molecule itself with surface‐adsorbed stabilizers providing colloidal stability (Fig. ).…”

Section: Nanomedicinementioning

confidence: 99%

Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis

Donnellan

Giardiello

2019

J of Interdiscip Nanomed

Self Cite

View full text Add to dashboard Cite

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes the most human deaths than any other diseases from a single infectious agent. Treatments are long and costly and have many associated side effects. Intracellular bacilli are slow growing and difficult to target, which is augmenting the emergence of multi-drug resistance. A hallmark trait of TB is the formation of granulomas, chronic cellular aggregates, which limit bacterial growth but provides a survival reservoir where bacilli may disseminate from. Targeting intracellular Mtb is challenging, but nanomedicine may offer a solution. Nanomedicine is a significantly growing research area and offers the potential for specific disease targeting, dosage reduction, and intracellular drug delivery. This review discusses the application of the various forms of nanomedicine towards targeting of Mtb.

show abstract

“…Nanomedicine can be categorised as one of four types: nanocarriers, polymer therapeutics, solid drug nanoparticles (SDN), and inorganic nanoparticles (NPs) (Niemirowicz et al, 2012;Busquets et al, 2015;McDonald et al, 2015;Giardiello et al, 2016;Saravanan et al, 2018). The conjugation between drugs and watersoluble polymers is aimed at overcoming bioavailability issues through drug encapsulation onto nanoparticle surfaces or within nanocarriers.…”

Section: Nanomedicine -The Scope Of Poverty Related Diseases (Prd)mentioning

confidence: 99%

Barriers for the development, translation, and implementation of nanomedicine: an African perspective

Saravanan

Ramachandran

Barabadi

et al. 2018

J of Interdiscip Nanomed

Self Cite

View full text Add to dashboard Cite

Nanotechnology is a branch of science, which empowers innovation to discover new medical technologies, improving current diagnostic and treatment methods. The scope of nanotechnology focuses mainly on "technology transfer", in which research aims to facilitate the application of recent nanoscience techniques to conventional medicine development methodologies. Nanomedicine is attractive to researchers who wish to target specific infectious diseases associated with poverty, which is highlighted through the many pertinent examples of recent breakthroughs in nanomedicine. An overview is provided in this study to highlight the barriers and implementation of nanomedicine for various infectious diseases in the African continent. Patient backgrounds provide the greatest of challenges for new technologies in terms of improving bioavailability and dosage. This review points out the current situation of nanomedicine in Africa and explores the possibility of how nanomedicine could improve patient drug regimens and wellbeing.

show abstract

The Application of Nanotechnology to Drug Delivery in Medicine

Cited by 17 publications

References 176 publications

Preliminary Assays towards Melanoma Cells Using Phototherapy with Gold-Based Nanomaterials

Preliminary Assays towards Melanoma Cells Using Phototherapy with Gold-Based Nanomaterials

Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis

Barriers for the development, translation, and implementation of nanomedicine: an African perspective

Contact Info

Product

Resources

About