The Application of Multi-Agent System in Monitoring and Control of Nonlinear Bioprocesses

An Alternative Approach for Oscillatory Behaviour Control in a Nonlinear Bioprocess

“…The next step is to find an appropriate degree of dilution (γ) of the additional substrate. As we shall see, the degree of dilution should be sufficiently high to have a possibility to attenuate the sustained oscillations, but sufficiently small to not cause a significant reduction in the biomass productivity (Skupin and Metzger, 2012). It is obvious that the smaller the inlet concentration (1-γ)•S in2 , the smaller is the biomass concentration (and the biomass productivity as well), what has been shown in (Nelson and Sidhu, 2005) for a single limiting substrate.…”

“…Otherwise, e.g. for too low degrees of dilution, the attenuation of oscillations in the whole range of dilution rates would be impossible (Skupin and Metzger, 2012). Moreover, irrespective of the value of the r parameter, the washout always occurs for some critical dilution rate and the biomass concentration drops to zero.…”

“…Because of the nonlinear nature of these processes, various nonlinear phenomena such as multiplicity of steady states, limit cycles or even chaos (Graham et al, 2007) are often observed. Particular attention is drawn to the self-sustained oscillations (SSO) of biomass concentration, which take place in continuous flow bioreactors for some range of dilution rates at constant substrate concentration in the feed (Sohn et al, 2000). Many papers also describe the application of the oscillatory behaviour in improvement of the bioreactor performance.…”

Direct metabolic activity measurement for unstable bioprocess experiment control

“…Then, based on the given conditions, we will discuss the problem of model selection of the bioprocess and estimation of the key process parameters. The presented results are based on our earlier researches [4,[9][10][11].…”