The application of human amniotic membrane in the surgical management of limbal stem cell deficiency

Le, Qihua; Deng, Sophie X.

doi:10.1016/j.jtos.2019.01.003

Cited by 51 publications

(51 citation statements)

References 158 publications

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“…86 Indeed, there is some evidence that using intact AM allows some LSCs to undergo epithelial-mesenchymal transition and invade the limbal stroma. 87,88 AM has been shown to preserve limbal epithelial cells in an undifferentiated state, maintaining its naturally occurring slow cycling. 88,91 Evidence suggests that AM provides a unique stromal microenvironment beneficial for LSC survival and expansion, whilst acting as an IL-1 antagonist to prevent cell apoptosis.…”

Section: Cultivated Stem Cell Transplantationmentioning

confidence: 99%

<p>Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective</p>

Walkden¹

2020

OPTH

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The aim of this paper is to provide a succinct literature review of the different clinical applications for AMT usage in an ophthalmic setting, ranging from commonly used applications to less mainstream approaches. The hope is that this review enables the reader to have a better understanding of the biological properties of amnion as well as the indications and scenarios in which AMT can be used, whilst presenting relevant evidence from within the literature which may be of interest. We also provide an update on the methods of preservation of amniotic membrane and the application methodologies. Methods: Literature search. A PubMed search was performed using the search terms "amniotic membrane transplant", "amnion AND cornea", amnion AND ophthalmology", "amnion AND ocular surface" and "Amnion AND eye". A full review of the literature using the PubMed database was conducted up until 01/05/20. The articles used were written in English, with all articles accessed in full. Both review articles and original articles were used for this review. All full publications related to ophthalmology were considered.

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Section: Cultivated Stem Cell Transplantationmentioning

confidence: 99%

<p>Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective</p>

Walkden¹

2020

OPTH

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“…Acellular amniotic membrane (AM) patch has been used in various surgeries, because it contains essential proangiogenic growth factors, including fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) that also promote endogenous mechanisms of repair and regeneration, such as angiogenesis or vasculogenesis [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Acellular Membrane Amniotic (Am)mentioning

confidence: 99%

“…The basement membrane AM promotes differentiation and migration of epithelial cells and also enhances the adhesion of basal epithelial cells. It also produces various growth factors such as fibroblast growth factor and transforming growth factor, which promotes epithelialization [15].…”

Section: Anti-inflammatory Potential Amniotic Membrane (Am)mentioning

confidence: 99%

“…Another advantage of AM fundamental for use in tissue engineering are its anti-inflammatory, anti-bacterial, antis-caring, immunomodulatory, anti-angiogenic, anti-fibrotic, hemocompatibility and low immunogenicity property [15][16][17][18].…”

Section: Anti-inflammatory Potential Amniotic Membrane (Am)mentioning

confidence: 99%

“…The human amniotic membrane has been used as biomaterials in the treatment of ocular surgery of wounds, burns, transplants and reconstructive surgery, due to its low cost and is used for different functions [15]. On Bioengineering Research involving this biomaterial has a collection that is constantly fed into the new discoveries of uses and forms of the same [16].…”

Section: Clinical Uses Of Amniotic Membrane In Woundsmentioning

confidence: 99%

See 2 more Smart Citations

Acellular Amniotic Membrane Patch Regeneration for Burn Injury: The Future for Wound Healing

Dias¹,

Machado²,

Kochla³

et al. 2019

JBiSE

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Acellular amniotic membrane (AAM) is a biodegradable and biocompatible natural that has a wide range of applications in the field of pharmaceutics, biomedical, chemical and cosmetics industry. One of the most interesting characteristics of AAM is its antibacterial and anti-inflammatory, anti-angiogenic, anti-fibrosis activity is an attractive approach for treating inflammatory disorders, wounds, and burns. The isolated use of AAM may not be sufficient to produce an adequate anti-inflammatory and antimicrobial effect to fulfill different purposes, has attracted considerable attention that has similar properties to the native tissues. This mini-review offers a focuses on modern aspects of the biomaterials, growth factors, biocompatibility, and acellular matrix which are the basic elements for use in the tissue regeneration and replacement after an injury.

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Amniotic membrane transplantation for acute ocular burns

Clare

Bunce²,

Tuft

2022

Cochrane Database of Systematic Reviews

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The application of human amniotic membrane in the surgical management of limbal stem cell deficiency

Cited by 51 publications

References 158 publications

<p>Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective</p>

<p>Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective</p>

Acellular Amniotic Membrane Patch Regeneration for Burn Injury: The Future for Wound Healing

Amniotic membrane transplantation for acute ocular burns

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