The Application of Ciclopirox as a Nail Lacquer is Prophylactic for Unguis (Nail) Diseases

Abstract

Today a wide-ranging number of population in the world suffering from diseases related to nail. So, in this article, the drug delivery over nail by using nail lacquer which contain Ciclopirox drug has discussed. Trans ungual drug delivery system is related with the drug delivery over the nail which because of keratin network present into the nail. The drug delivery via nail plate which is a hard material is done due to association of several diseases into nail for e.g., onychomycosis, psoriasis, paronychia, onycholysis. These diseases occur due to some microorganisms, fungi, bacteria & parasites. There are several factors responsible for trans ungual drug delivery system such as molecular size of drug, hydrophilicity and lipophilicity of molecule, nature of vehicle, formulation effect. Nail lacquer has film formation mechanism which forms film on nail bed and drug penetrate the content into the nail plate during application. Direct penetration of the drug molecule is difficult so, for the drug delivery we use penetration enhancers. Nail lacquers deliver by many methods like physical, chemical and mechanical via nail plate. There are several medications available in the market for prophylaxis of nail diseases. Generally used medications are fluconazole, Itraconazole, butenafine are the antifungals and antibiotics such as ciprofloxacin, levofloxacin. Now a days many brands of nail lacquer are available in market such as PENLAC, ONYLAC, NAILON, LOCERYL, ECONAIL. In this article we mostly focused on PENLAC {ciclopirox 8%} brand of nail lacquer and have mentioned some instructions related to application of nail lacquer on the nail for patient to get better topical effect.