The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review

Abstract

Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. This review aims to present an overview of evidence-based clinical indications for regenerative therapy with EMD.

A review on endogenous regenerative technology in periodontal regenerative medicine

“…Attachments are characterized by the presence of new acellular and/or cellular cementum with inserting collagen fibers and new alveolar bone [22]. Although Emdogain Ò has been commercialized for just over a decade, it is widely used in periodontical practice and for replanting teeth [20,21]. Results from basic research have suggested that EMD has an important role in periodontal wound healing.…”

Root Biomodification in Periodontics - The Changing Concepts

“…It is extracted from developing embryonal enamel of porcine origin and contains several matrix proteins from the amelogenin family. Several studies have shown that EMD influences the migration, attachment, proliferative capacity and biosynthetic activity of periodontal ligament cells [59,[67][68][69].…”

Mucosal Substitutes for Periodontal Soft Tissue Regeneration

“…A commercially prepared and purified extract of enamel matrix proteins, EMD is composed primarily of amelogenin and has been shown to promote PDL fibroblast proliferation and growth [10]. The effects of Emdogain are thought to be the induction of proliferation, migration, adhesion, mineralization and differentiation of cells in periodontal tissue.…”