The Appearance of Blood Group and Organ-Specific Antigens in Human Gastric Glycoproteins

Häkkinen, I; Virtanen, S

doi:10.1159/000230353

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…On the other hand, glycoproteins from young controls regularly showed a physico-chemically monodisperse picture when put against the blood group antiserum. All control samples were FSA-negative but had N" antigen in their blood group glycoproteins [15]. In samples from cancerous gas tric juice FSA without blood group antigens could very often be demon strated.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly we prepared 74 cancerous gastric juice samples -51 from persons in blood group A and 23 from persons in group B, as well as 28 samples from young normal controls, 17 of which belonged to blood group A and 11 to B. The antisera used were: anti-FSA serum prepared in rabbits and absorbed with salivary glycoproteins of a normal young person in blood group O as described earlier [9,11]; anti-N" serum prepared by immunizing rabbits with normal gastric glycoprotein antigen [11,15] and hyper-immune human anti-A and anti-B sera (standard preparations from the Finnish Red Cross Transfusion Centre). The blood group antisera were selected and tested to give a specific precipitation line in the Ouchterlony plate against compatible blood group glycoproteins of ovarian cyst origin.…”

Section: Methodsmentioning

confidence: 99%

“…Using the above techniques, the anti-FSA and anti-N" sera were checked to see that they did not contain specific blood group antibodies in the ABH system. The proofs for specificity of the anti-FSA and anti-N" to the antigens FSA and N," respectively, have been described else where (9,10,15]. The Ouchterlony immunodiffusion technique used was the mi cromethod of Wadsworth [21].…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, lack or decrease of blood group antigens seems to be characteristic of gastric malignancy [3]. Parallel to the decrease of blood group antigens, gastric cancer cells possess an additional A-likc antigen which can be found both in B and O subjects [8,15]. A similar phenomenon has been observed in cancer patients, by using tissue culture technique [2], and in the CEA of colonic cancer by a Canadian group [1,6].…”

mentioning

confidence: 87%

“…According to their results it seems unlikely that the A-like antigen is identical with the true A antigen which is determined by N-acetylgalactosamine. The group of blood group glycoproteins in the stomach includes still other antigens which are believed to be organ-specific [11,13,15].…”

mentioning

confidence: 99%

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Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Häkkinen¹

1974

Int Arch Allergy Immunol

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Acid gastric glycoproteins deriving from 180 non-cancerous FSA secretors, 74 gastric cancer patients (FSA positives), and 28 young controls (FSA negatives), all in blood group A or B were analyzed for content of blood group antigens and for the relation of FSA (or N_o in young controls) to these. The Ouchterlony analysis revealed six different combinations in the same glycoprotein molecules or separately. There seemed to be a trend towards disappearance of blood group antigens in gastric cancer, although some of the non-cancerous FSA positives and gastric cancer samples showed quite a similar polydisperse picture. The glycoproteins deriving from young controls were strictly monodisperse and showed a strong positivity for blood group antigens. The practical importance of the present data lies in the fact that they provide the possibility of following the FSA blood group picture of non-cancerous FSA positives. This may warrant further clinical examinations as the picture alters.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 87%

mentioning

confidence: 99%

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Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Häkkinen¹

1974

Int Arch Allergy Immunol

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Canine gastric glycoprotein antigens in early carcinogenesis

Häkkinen

Heinonen

Isberg

et al. 1984

Cancer

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The effect of one single dose of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) on the antigenic structures of gastric juice glycoproteins, was studied in dogs. Antisera to glycoproteins of the fetal alimentary canal were raised. Histologic mucosal specimens and glycoprotein fractions of gastric juice which were taken from four dogs during a 15.5‐month period after MNNG administration, were examined immunohistologically and by immunodiffusion for the appearance of fetal‐like antigens. Fetal‐like structures appeared in a stepwise manner in both the acid and neutral glycoprotein fractions of the gastric juice, and showed gradual crossreactivity between macromolecules obtained from gastric juice samples obtained during the observation period. Eight immunizations carried out using physicochemically different glycoprotein fractions of fetal canine alimentary canal mucosa, produced a similar response, thus indicating that the same antigenic structures are incorporated into all mucus glycoproteins, even though they do differ physicochemically. It is suggested that this “omnipotential” incorporation picture could also be found after exposure to MNNG and is, by its nature, typically fetal.

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The reversal immune surveillance hypothesis

Daunter¹,

Mackay²

1979

Medical Hypotheses

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The Appearance of Blood Group and Organ-Specific Antigens in Human Gastric Glycoproteins

Cited by 4 publications

References 10 publications

Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Canine gastric glycoprotein antigens in early carcinogenesis

The reversal immune surveillance hypothesis

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