The Apoptosis of Blood Neutrophils and Immunoregulatories Cytokines in Patients with Autoimmune Thyropaties

Уразова, О. И.; Kravez, E B; Новицкий, В. В.; Кузнецова, В. Н.; Рогалева, А. В.

doi:10.14341/ket20073449-53

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…At the same time, experi-Halyna Pavlyshyn, Iryna Sarapuk The role of neutrophils and their apoptosis in the resolution of inflammation ments show that in healthy donors, changes in neutrophil programmed death occur when oxidative stress is modeled in vitro and these changes are similar to those found during the course of inflammatory diseases [44]. Neutrophils also participate in the destruction of the thyroid gland during autoimmune processes accompanied by the increased consumption of oxygen and production of its toxic metabolites, which under the conditions of antioxidant deficiency, cause the programmed death of thyroid cells and polymorphonuclear neutrophils [45].…”

Section: Proapoptotic and Anti-apoptotic Factorsmentioning

confidence: 88%

The Role of Neutr Ophils and Their Apoptosis in There Solution of Inflammation

Pavlyshyn¹,

Sarapuk²

2015

PU-HSP

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puls Uczelni 2015 (9) 4Niniejszy materiał jest udostępniony na licencji creative commons -Uznanie autorstwa 4.0 pL.Pełne postanowienia tej licencji są dostępne na: http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode Prace poglądowe | Reviews DOI: 10.5604/2081DOI: 10.5604/ -2021 tHe rOLe OF NeUtrOpHiLS AND tHeir ApOptOSiS iN tHe reSOLUtiON OF iNFLAMMAtiONRola granulocytów obojętnochłonnych i ich apoptozy w zwalczaniu stanu zapalnego A -przygotowanie projektu badania | study design, B -zbieranie danych | data collection, C -analiza statystyczna | statistical analysis, D -interpretacja danych | data interpretation, E -przygotowanie maszynopisu | manuscript preparation, F -opracowanie piśmiennictwa | literature search, G -pozyskanie funduszy | funds collection SUMMARY Inflammation, as a part of the body's immune response, is present in the progression of most diseases. Neutrophils form the first line of the defense against invading pathogens and subsequently play a prominent role in the resolution of inflammation.They have a protective function as they release antibacterial enzymes and generate reactive oxygen species. Neutrophils are able to regulate the inflammatory reaction by undergoing apoptosis. Apoptosis, then, facilitates cellular homeostasis ( immune defense), promotes the elimination of activated cells of the immune system, and can act as a major pathogenetic link of an inflammation process, defining its character. This review highlights the mechanisms of apoptosis, the influence of external and internal factors and infectious agents (viruses, extracellular and intracellular microorganisms) on the enactment of neutrophil programmed death and the resolution of inflammation. Keywords: neutrophils, apoptosis, inflammation STRESZCZENIEStan zapalny jako część odpowiedzi immunologicznej organizmu jest patologiczną podstawą większości chorób. Granulocyty obojętnochłonne tworzą pierwszą linię obrony przed inwazją patogenów i odgrywają znaczącą rolę w zwalczaniu stanu zapalnego. Realizują one funkcję ochronną poprzez uwalnianie enzymów przeciwbakteryjnych i wytwarzanie wolnych rodników. Granulocyty obojętnochłonne są w stanie regulować reakcję zapalną poprzez apoptozę. Apoptoza zapewnia homeostazę komórek, ochronę immunologiczną, nasila eliminację aktywowanych komórek układu odpornościowego oraz może stanowić znaczący związek patogenetyczny z procesem zapalnym, określając jego charakter. W artykule zwrócono uwagę na mechanizmy apoptozy, wpływ czynników zewnętrznych i wewnętrznych oraz czynników zakaźnych (wirusy, wewnątrzkomórkowe i zewnątrz-komórkowe mikroorganizmy) na realizację zaprogramowanej śmierci granulocytów obojętnochłonnych i zwalczanie stanu zapalnego.Słowa kluczowe: granulocyty obojętnochłonne, apoptoza, stan zapalny (PU-HSP 2015; 9, 4: 18-25)

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Section: Proapoptotic and Anti-apoptotic Factorsmentioning

confidence: 88%

The Role of Neutr Ophils and Their Apoptosis in There Solution of Inflammation

Pavlyshyn¹,

Sarapuk²

2015

PU-HSP

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Proinflammatory cytokine shift and changes in lymphocyte activation markers in patients with autoimmune thyroiditis and reproductive dysfunction

Ismailova,

Khegay

2024

General Physician

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The article is devoted to the problem of autoimmune thyroiditis (AIT), a disease of the thyroid gland, which is quite common in women and ranks first in the structure of causрm es of irregular periods, infertility, and miscarriage. The clinical characteristics and analysis of indicators of thyroid status, cytokine profile, and lymphocyte activation markers in 80 patients with autoimmune thyroiditis and reproductive dysfunction are presented. The obрm tained results indicate various thyroid disorders in patients with AIT, in particular, the levels of TPO and ATG antibodies were increased by 98 and 39 times, respectively, relative to the control; the level of IL-1ѓА was 10 times higher, IL-6.16 times higher, the concentration of TNF-ѓї.. more than 13 times higher, and the level of IL-18 was 1.9 times lower in patients with AIT compared with the values obtained in the patients with impaired reproductive funcрm tion without thyroid pathology. The research results prove the undeniable pathogenetic role of cytokines and lymphocyte activation markers in the development of the AIT inflammatory process.

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The Apoptosis of Blood Neutrophils and Immunoregulatories Cytokines in Patients with Autoimmune Thyropaties

Cited by 2 publications

References 3 publications

The Role of Neutr Ophils and Their Apoptosis in There Solution of Inflammation

The Role of Neutr Ophils and Their Apoptosis in There Solution of Inflammation

Proinflammatory cytokine shift and changes in lymphocyte activation markers in patients with autoimmune thyroiditis and reproductive dysfunction

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