The Apolipoprotein B/A1 Ratio is Associated with Reactive Oxygen Metabolites and Endothelial Dysfunction in Statin-Treated Patients with Coronary Artery Disease

Emoto, Takuo; Sawada, Takahiro; Morimoto, Natsumi; Tenjin, Takako; Wakimoto, Taku; Ikeda, Fumie; Sato, Chiaki; Terashita, Daisuke; Mizoguchi, Takahiro; Mizuguchi, Toru; Okamoto, Hiroshi; Matsuo, Yosuke; Kim, Sushi-ku; Takarada, Akira; Yokoyama, Mitsuhiro

doi:10.5551/jat.16824

Cited by 12 publications

(11 citation statements)

References 21 publications

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“…There are several mechanisms might explain the increased risk of PTB among women with higher serum ApoB level or ApoB/ApoA-1 ratio. Previous studies have revealed a positive association between ApoB level and oxidative stress 36 . Elevated level of oxidative stress during pregnancy is related to higher risk of PTB 37 .…”

Section: Discussionmentioning

confidence: 93%

“…Elevated level of oxidative stress during pregnancy is related to higher risk of PTB 37 . Furthermore, both experimental 38, 39 and epidemiological studies 36,40 have reported that elevated ApoB level or ApoB/ApoA-1 ratio was associated with endothelial damage. Chen et al 41 reported that impaired endothelial function was present in women with preterm delivery.…”

Section: Discussionmentioning

confidence: 97%

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Associations between maternal mid-pregnancy apolipoprotein A-1, apolipoprotein B, apolipoprotein B/apolipoprotein A-1 ratio and preterm birth: An observational study

Liu

Wang

et al. 2021

Preprint

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Objective: To investigate the association between maternal apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), ApoB/ApoA-1ratio and preterm birth (PTB). Design: Observational survey. Setting: Guangdong Women and Children Hospital, China Samples: 5986 pregnant women. Method: Data were extracted from the information system of Guangdong Women and Children Hospital. Maternal serum ApoB, ApoA-1 and ApoB/ApoA-1 ratio were categorized into tertiles. Logistic regression models were performed to evaluate the odds ratios and 95% confidence intervals for PTB. Main outcome measures: PTB (gestational age < 37 weeks) Results: Of the study participants, the rate of preterm birth was 5.7% (n= 344). Compare with individuals in the lowest tertile, the adjusted ORs of PTB was 1.41 (95% CI: 1.07-1.87) for individuals in the highest tertile of ApoB and 1.35 (95% CI: 1.03-1.78) for those in the highest tertile of ApoB/ApoA-1. The association of ApoB/ApoA-1 and PTB was more relevant among women with pre-pregnancy BMI ≤ 24 kg/m2, age at delivery ≥ 35 years or those who were multiparous. Conclusions: Elevated maternal ApoB level and ApoB/ApoA-1 ratio during mid-pregnancy were related to increased risk of PTB. Monitoring serum apolipoprotein levels may help to prevent preterm birth. Funding: The study was funded by grants 2019FYH003 from Chinese Center for Disease Control and Prevention. Keywords: Apolipoprotein A-1, Apolipoprotein B, Apolipoprotein B/Apolipoprotein A-1, Preterm birth Tweetable abstract：Maternal mid-pregnancy ApoB level and ApoB/ApoA-1 ratio were associated with PTB.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Associations between maternal mid-pregnancy apolipoprotein A-1, apolipoprotein B, apolipoprotein B/apolipoprotein A-1 ratio and preterm birth: An observational study

Liu

Wang

et al. 2021

Preprint

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“…The apo B/apo A1 ratio is a typical marker for the atherogenic /antiatherogenic condition, and a higher apo B/apo A1 ratio represents progression in the atherosclerotic state. Previous studies have suggested that a high apo B/apo A1 ratio strongly correlates with pathophysiological markers of atherosclerosis defined by coronary angiography [ 8 , 20 ], and calcium scores of the coronary arteries [ 21 ], and by ultrasound techniques such as the thickness of carotid arteries [ 16 , 22 , 23 ], endothelial dysfunction [ 24 ] and existence of femoral plaques [ 25 ]. In addition, a high apo B/apo A1 ratio can also be used to predict risk of carotid plaque development [ 26 ] and major adverse cardiovascular events [ 14 , 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients

et al. 2018

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BackgroundTo investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients.MethodsEight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models.ResultsOf the 860 patients, the mean age was 49.9 ± 14.5 years, 57.6% were men, and 19.3% were diabetic patients. The median apo B/apo A1 ratio was 0.65 (range: 0.22–2.24). During a median follow-up period of 27 months (interquartile range, 13 – 41 months), 202 deaths, and 145 cardiovascular events were recorded. After adjustment for age, sex, body mass index, diabetes, cardiovascular disease, systolic blood pressure, total Kt/V, estimated glomerular filtration rate, hemoglobin level, neutrophil to lymphocyte ratio and albumin, triglyceride, and cholesterol, as well as the use of lipid-lowering agents, the highest apo B/apo A1 ratio tertile was significantly associated with a hazard ratio for all-cause mortality of 1.60 (95% CI: 1.02 to 2.49, P = 0.040) and for cardiovascular events of 2.04 (95% CI: 1.21 to 3.44, P = 0.008).ConclusionAn increased apo B/apo A1 ratio was independently associated with all-cause mortality and cardiovascular events in PD patients.

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“…It is a general belief that an important anti-atherogenic substance, Apolipoprotein A1 (ApoA1), is considered as in case of High-Density Lipoprotein (HDL), enters into the vascular wall from the vascular lumen to act against atherosclerosis by mediating reverse cholesterol transport [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Migration of ApoA1+ Macrophage Phenotypes from Pericoronary Adipose Tissue to Coronary Plaque: A Possible Mechanism for Suppression of Human Coronary Atherosclerosis

Hiruta¹,

Uchida²,

Shimoyama³

et al. 2020

Int J Clin Cardiol Res

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Background: Apolipoprotein A1 (ApoA1) is an important anti-atherogenic protein. We previously found that ApoA1 is stored in human Pericoronary Adipose Tissue (PCAT) and macrophages residing in PCAT accumulate ApoA1. Here, we aimed to identify whether and how the macrophage phenotypes transport ApoA1 from PCAT to the atherosclerotic coronary plaques.Methods: Coronary arteries and their surrounding PCAT were excised from human autopsy subjects and examined using immunohistochemical techniques to investigate macrophage-mediated ApoA1 transport from PCAT to the coronary intima.Results: CD68 + and CD206 + macrophages containing ApoA1 were observed in PCAT of both normal coronary segments (normal group) and coronary segments with plaques (plaque group).External Elastic Lamina (EEL) was loosened or fragmented, and Internal Elastic Lamina (IEL) was disrupted in the plaque group. ApoA1-containing CD68 + and CD206 + macrophages (M2 macrophages), extending pseudopod forward, were frequently observed to pass through these portions into the intima. ApoA1-containing CD11c + macrophages (M1 macrophages) were not found in PCAT, EEL, or media, but were found in disrupted IEL and plaques. Conclusions:The results suggest that CD206 + or CD68 + macrophages transport ApoA1 from PCAT into the media and they and CD11c + macrophages transformed at the site of IEE into plaque via loosened or fragmented EEL and disrupted IEL and could participate in the suppression of coronary atherosclerosis.

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The Apolipoprotein B/A1 Ratio is Associated with Reactive Oxygen Metabolites and Endothelial Dysfunction in Statin-Treated Patients with Coronary Artery Disease

Abstract: Aim:The prognostic significance of the apolipoprotein B/A1 (ApoB/A1) ratio in statintreated patients with coronary artery disease (CAD) is unknown. We aimed to evaluate the association of the ApoB/A1 ratio with oxidative stress and endothelial dysfunction in these patients.

Cited by 12 publications

References 21 publications

Associations between maternal mid-pregnancy apolipoprotein A-1, apolipoprotein B, apolipoprotein B/apolipoprotein A-1 ratio and preterm birth: An observational study

Associations between maternal mid-pregnancy apolipoprotein A-1, apolipoprotein B, apolipoprotein B/apolipoprotein A-1 ratio and preterm birth: An observational study

Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients

Migration of ApoA1+ Macrophage Phenotypes from Pericoronary Adipose Tissue to Coronary Plaque: A Possible Mechanism for Suppression of Human Coronary Atherosclerosis

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