The antipyretic effect of indomethacin.

Clark, William G.; Cumby, H R

doi:10.1113/jphysiol.1975.sp010992

Cited by 91 publications

(45 citation statements)

References 27 publications

(27 reference statements)

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“…NSAIDs act through the inhibition of PG biosynthesis due to the irreversible acetylation of the COX site, leaving the peroxidase activity of the enzyme unaffected [30]. Generally, the antipyretic mechanism of NSAIDs comprises inhibition of prostaglandin biosynthesis within the hypothalamus [31]. The ability of the extracts to cross the brain blood barrier is a factor that may have contributed to the observed antipyretic activity of the extracts.…”

Section: Discussionmentioning

confidence: 99%

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

PM¹,

JK²,

Vz³

et al. 2016

J App Pharm

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Interest in herbal drugs is undergoing a renaissance at present time. Herbal agents are regarded to be more effective and comparatively safe as opposed to conventional medications which are relatively inaccessible and arguably associated with various adverse effects. Harrisonia abyssinica and Landolphia buchananii have been used by the Ameru and Embu communities to alleviate various ailments. However, despite their wide folklore use, extensive literature research reveals limited scientific evaluation of their described effects. Thus, the current study aimed to evaluate the antipyretic effects of their methanolic extracts. The plant samples were sourced from Mbeere, Embu County, Kenya. The test subjects (experimental rats) were grouped into four; normal group, a negative control group, reference group and experimental groups. The experimental groups were treated with stem bark extracts at concentration of 50 mg/kg, 100 mg/kg and 150 mg/kg. The determination of antipyretic activities was evaluated by using a 20% turpentine solution as the pyrexia inducing agent and then compared with aspirin as the reference drug. H. abyssinica extract reduced the rectal temperature by between 0.90% and 1.73% while L. buchananii extract reduced it by between 0.32% and 2.52%. Aspirin reduced the elevated rectal temperature by 1.70% and 2.32%. Qualitative phytochemical screening results showed that the extracts possessed several phytochemicals. The results of the study have confirmed the folklore use of the aforementioned plants in the suppression of pyrexia.

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Section: Discussionmentioning

confidence: 99%

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

PM¹,

JK²,

Vz³

et al. 2016

J App Pharm

View full text Add to dashboard Cite

show abstract

“…In a further series of experiments, 28 n-mole of the prostaglandin endoperoxide was injected together with an antipyretic dose (28 n-mole) of indomethacin (Sigma) dissolved in 10 ,u. ethanol (Clark & Cumby, 1975). The solutions were flushed through the injection cannula with 30 ,d. sterile distilled water.…”

Section: Methodsmentioning

confidence: 99%

Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits.

Harrisberg¹,

Laburn²,

Mitchell³

1979

The Journal of Physiology

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SUMMARY1. Derivatives of arachidonic acid other than prostaglandin are pyrogenic, the likely candidates being the prostaglandin endoperoxides and/or the thromboxanes.2. Intraventricular microinjections in rabbits of a stable analogue of prostaglandin endoperoxide resulted in dose-dependent increases of rectal temperature. The pyrexia was delayed in onset; no significant change in body temperature occurred for at least an hour.3. The pyrexia was unaltered by simultaneous injection of the potent prostaglandin synthetase inhibitor indomethacin.4. We suggest that both prostaglandins and prostaglandin endoperoxides may be implicated in fever.

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“…Deviation of body temperature from base line was tabulated at 15 min intervals, and changes in temperature were quantified as a 'thermal response index' (TRI; Clark, 1970), one unit of which is equivalent to a 1°C change lasting for 1 h (Clark & Cumby, 1975). TRIs were determined from the time of the final injection for the number of hours indicated by a subscript.…”

Section: Methodsmentioning

confidence: 99%

The Antipyretic Effect of Tilorone Hydrochloride in the Cat

Clark

Robins

1978

British J Pharmacology

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The antipyretic activity of tilorone hydrochloride was studied in conscious, unrestrained cats provided with implanted jugular venous catheters, third cerebral ventricular (i.c.v.) cannulae and retroperitoneal thermocouples. In afebrile animals, 10 mg/kg i.v. or 1 mg i.c.v. tilorone hydrochloride did not alter body temperature, but 20 mg/kg i.v. or 2 to 5 mg i.c.v. caused hypothermia and various behavioural responses. Non‐hypothermogenic doses of tilorone (i.v. or i.c.v.) antagonized hyperthermic responses to leucocytic pyrogen (i.v. or i.c.v.), bacterial pyrogen (i.c.v.) and sodium arachidonate (i.c.v.) but did not antagonize prostaglandin E1 (i.c.v.). These results indicate that tilorone has an antipyretic action within the central nervous system that is distinct from its hypothermogenic action. Although there is no published evidence to indicate that tilorone can inhibit prostaglandin synthesis peripherally, its ability to reduce hyperthermic responses to arachidonate suggests that it can inhibit prostaglandin synthesis within the brain.

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The antipyretic effect of indomethacin.

Cited by 91 publications

References 27 publications

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits.

The Antipyretic Effect of Tilorone Hydrochloride in the Cat

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