Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits.

Harrisberg, C J; Laburn, Helen P.; Mitchell, David

doi:10.1113/jphysiol.1979.sp012797

Cited by 8 publications

(1 citation statement)

References 10 publications

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“…Another candidate is prostacyclin, intraventricular injections of which are pyrogenic in rabbits (Milton, Cremades-Campos, Sawhney & Bishard, 1980) and at higher doses in cats (Clark & Lipton, 1979;Milton et al 1980). The cyclic endoperoxides may be involved directly, although current evident is equivocal (Hawkins & Lipton, 1977; Harrisberg, Laburn & Mitchell, 1979;Milton et al 1980).…”

Section: Resultsmentioning

confidence: 99%

Intraventricular injections of drugs which inhibit phospholipase A2 suppress fever in rabbits.

Cranston¹,

Hellon²,

Mitchell³

et al. 1983

The Journal of Physiology

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SUMMARY1. Injection of two chemically dissimilar inhibitors of phospholipase A2 (mepacrine and parabromophenacylbromide) into the cerebral ventricles of rabbits inhibited the febrile response to endogenous pyrogen given by the same route.2. The same doses of the inhibitors given intravenously did not affect the febrile response to endogenous pyrogen given into the ventricles, indicating that their action was central.3. When given intraventricularly the inhibitors did not affect the maintenance of core temperature in a cold environment, indicating that they did not impair thermoregulatory ability. 4. The inhibitors had no effect on the temperature rise following intraventricular injection of arachidonic acid.5. These observations are compatible with the proposition that one or more metabolic products of arachidonic acid other than prostaglandin are involved in pyrogenesis.

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Section: Resultsmentioning

confidence: 99%