The antipruritic effect of 5% doxepin cream in patients with eczematous dermatitis. Doxepin Study Group

Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema

“…This may indicate that DOX sufficiently penetrated the skin and successfully inhibited the spread of erythema, the efferent part of the axon reflex caused by ACH. This is in agreement with results from Drake & Millikan (28) who observed a visible reduction of inflammation and eczema severity in a study with 270 AE and 309 lichen simplex patients. Obviously the penetration of DOX was sufficient enough to affect the cutaneous response without the side effects such as stinging or self potentiating allergic contact dermatitis that had been previously reported in patients with higher dosages of Zonalon ® cream or long‐term usage (40).…”

Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema

“…This may indicate that DOX sufficiently penetrated the skin and successfully inhibited the spread of erythema, the efferent part of the axon reflex caused by ACH. This is in agreement with results from Drake & Millikan (28) who observed a visible reduction of inflammation and eczema severity in a study with 270 AE and 309 lichen simplex patients. Obviously the penetration of DOX was sufficient enough to affect the cutaneous response without the side effects such as stinging or self potentiating allergic contact dermatitis that had been previously reported in patients with higher dosages of Zonalon ® cream or long‐term usage (40).…”

Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities

“…Menthol is a benign agent with minimal side effects which can be used concurrently with systemic agents to relieve rash and itch [46]. Topical and oral doxepin have been found to relieve pruritus in the general patient population [47–49]. At this time, it is unknown whether other topical agents, such as antihistamines, lidocaine, and calamine, will provide adequate efficacy to alleviate pruritus induced by EGFRIs.…”

A systematic review of the safety of topical therapies for atopic dermatitis

“…Studies investigating the local effects of topical doxepin have demonstrated local side‐effects (stinging and burning) both in patients receiving active drug and in those receiving a control vehicle; however, the use of doxepin does result in significantly more sedation (15·5–28% vs. 2–2·5%) that is generally mild and transient 17,18 . Allergic contact dermatitis secondary to the use of topical doxepin has been reported and is well known; however, the specific incidence of this outcome cannot be established with certainty based on the available data 19–22 .…”

“…The literature search yielded 602 titles of which 105 were included, and five additional studies were identified through hand searches 6,17,18,26–29,39,41–46,48–50,52,54–57,70,77,128–130,145–227 . Inclusion criteria included: trials reported as full length, English‐language papers, a length of treatment of 2 weeks or longer, and a sample size of 20 or more.…”

Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema

“…This may indicate that DOX sufficiently penetrated the skin and successfully inhibited the spread of erythema, the efferent part of the axon reflex caused by ACH. This is in agreement with results from Drake & Millikan (28) who observed a visible reduction of inflammation and eczema severity in a study with 270 AE and 309 lichen simplex patients. Obviously the penetration of DOX was sufficient enough to affect the cutaneous response without the side effects such as stinging or self potentiating allergic contact dermatitis that had been previously reported in patients with higher dosages of Zonalon ® cream or long‐term usage (40).…”

Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities

“…Menthol is a benign agent with minimal side effects which can be used concurrently with systemic agents to relieve rash and itch [46]. Topical and oral doxepin have been found to relieve pruritus in the general patient population [47–49]. At this time, it is unknown whether other topical agents, such as antihistamines, lidocaine, and calamine, will provide adequate efficacy to alleviate pruritus induced by EGFRIs.…”

A systematic review of the safety of topical therapies for atopic dermatitis

“…Studies investigating the local effects of topical doxepin have demonstrated local side‐effects (stinging and burning) both in patients receiving active drug and in those receiving a control vehicle; however, the use of doxepin does result in significantly more sedation (15·5–28% vs. 2–2·5%) that is generally mild and transient 17,18 . Allergic contact dermatitis secondary to the use of topical doxepin has been reported and is well known; however, the specific incidence of this outcome cannot be established with certainty based on the available data 19–22 .…”

“…The literature search yielded 602 titles of which 105 were included, and five additional studies were identified through hand searches 6,17,18,26–29,39,41–46,48–50,52,54–57,70,77,128–130,145–227 . Inclusion criteria included: trials reported as full length, English‐language papers, a length of treatment of 2 weeks or longer, and a sample size of 20 or more.…”

Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema

“…This may indicate that DOX sufficiently penetrated the skin and successfully inhibited the spread of erythema, the efferent part of the axon reflex caused by ACH. This is in agreement with results from Drake & Millikan (28) who observed a visible reduction of inflammation and eczema severity in a study with 270 AE and 309 lichen simplex patients. Obviously the penetration of DOX was sufficient enough to affect the cutaneous response without the side effects such as stinging or self potentiating allergic contact dermatitis that had been previously reported in patients with higher dosages of Zonalon ® cream or long‐term usage (40).…”

Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities

“…Menthol is a benign agent with minimal side effects which can be used concurrently with systemic agents to relieve rash and itch [46]. Topical and oral doxepin have been found to relieve pruritus in the general patient population [47–49]. At this time, it is unknown whether other topical agents, such as antihistamines, lidocaine, and calamine, will provide adequate efficacy to alleviate pruritus induced by EGFRIs.…”

A systematic review of the safety of topical therapies for atopic dermatitis

“…Studies investigating the local effects of topical doxepin have demonstrated local side‐effects (stinging and burning) both in patients receiving active drug and in those receiving a control vehicle; however, the use of doxepin does result in significantly more sedation (15·5–28% vs. 2–2·5%) that is generally mild and transient 17,18 . Allergic contact dermatitis secondary to the use of topical doxepin has been reported and is well known; however, the specific incidence of this outcome cannot be established with certainty based on the available data 19–22 .…”

“…The literature search yielded 602 titles of which 105 were included, and five additional studies were identified through hand searches 6,17,18,26–29,39,41–46,48–50,52,54–57,70,77,128–130,145–227 . Inclusion criteria included: trials reported as full length, English‐language papers, a length of treatment of 2 weeks or longer, and a sample size of 20 or more.…”