1995
DOI: 10.1001/archderm.131.12.1403
|View full text |Cite
|
Sign up to set email alerts
|

The antipruritic effect of 5% doxepin cream in patients with eczematous dermatitis. Doxepin Study Group

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
22
0
1

Year Published

2007
2007
2022
2022

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 27 publications
(24 citation statements)
references
References 0 publications
1
22
0
1
Order By: Relevance
“…Menthol is a benign agent with minimal side effects which can be used concurrently with systemic agents to relieve rash and itch [46]. Topical and oral doxepin have been found to relieve pruritus in the general patient population [47–49]. At this time, it is unknown whether other topical agents, such as antihistamines, lidocaine, and calamine, will provide adequate efficacy to alleviate pruritus induced by EGFRIs.…”
Section: Results and Recommendationsmentioning
confidence: 99%
“…Menthol is a benign agent with minimal side effects which can be used concurrently with systemic agents to relieve rash and itch [46]. Topical and oral doxepin have been found to relieve pruritus in the general patient population [47–49]. At this time, it is unknown whether other topical agents, such as antihistamines, lidocaine, and calamine, will provide adequate efficacy to alleviate pruritus induced by EGFRIs.…”
Section: Results and Recommendationsmentioning
confidence: 99%
“…These topical preparations were shown to reduce pruritus in patients with AD (38). However, topical doxepin is not an appropriate therapy for the pruritus of AD, given the concerns for topical sensitization as well as systemic absorption and drowsiness (39,40). …”
Section: Topical Treatmentsmentioning
confidence: 99%
“…45 Only topical doxepin, a tricyclic antidepressant and potent H1 and H2 antagonist, has been shown to significantly reduce pruritus in patients with AD, lichen simplex chronicus, contact dermatitis and nummular dermatitis. 46, 47 However, topical doxepin may cause localized burning, allergic contact dermatitis, and has been reported to cause drowsiness due to systemic absorption in up to 25% of patients. 46, 47 Thus, despite its potential benefit, use of topical doxepin is limited by its side effect profile and it is best avoided in children and used with caution in the elderly.…”
Section: Topical Antihistaminesmentioning
confidence: 99%